SHSA4_MOUSE
ID SHSA4_MOUSE Reviewed; 197 AA.
AC Q8CA71;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Protein shisa-4;
DE AltName: Full=Transmembrane protein 58;
DE Flags: Precursor;
GN Name=Shisa4; Synonyms=Tmem58;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the shisa family. {ECO:0000305}.
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DR EMBL; AK039457; BAC30354.1; -; mRNA.
DR EMBL; BC044813; AAH44813.1; -; mRNA.
DR CCDS; CCDS15319.1; -.
DR RefSeq; NP_780468.1; NM_175259.4.
DR RefSeq; XP_006530014.1; XM_006529951.3.
DR AlphaFoldDB; Q8CA71; -.
DR STRING; 10090.ENSMUSP00000046033; -.
DR iPTMnet; Q8CA71; -.
DR PhosphoSitePlus; Q8CA71; -.
DR MaxQB; Q8CA71; -.
DR PaxDb; Q8CA71; -.
DR PeptideAtlas; Q8CA71; -.
DR PRIDE; Q8CA71; -.
DR ProteomicsDB; 255424; -.
DR Antibodypedia; 65062; 60 antibodies from 21 providers.
DR DNASU; 77552; -.
DR Ensembl; ENSMUST00000041240; ENSMUSP00000046033; ENSMUSG00000041889.
DR GeneID; 77552; -.
DR KEGG; mmu:77552; -.
DR UCSC; uc007ctc.1; mouse.
DR CTD; 149345; -.
DR MGI; MGI:1924802; Shisa4.
DR VEuPathDB; HostDB:ENSMUSG00000041889; -.
DR eggNOG; ENOG502RY6V; Eukaryota.
DR GeneTree; ENSGT00730000111186; -.
DR HOGENOM; CLU_110080_0_0_1; -.
DR InParanoid; Q8CA71; -.
DR OMA; NPGFNCE; -.
DR OrthoDB; 1429667at2759; -.
DR PhylomeDB; Q8CA71; -.
DR TreeFam; TF332572; -.
DR BioGRID-ORCS; 77552; 4 hits in 72 CRISPR screens.
DR PRO; PR:Q8CA71; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8CA71; protein.
DR Bgee; ENSMUSG00000041889; Expressed in triceps brachii and 199 other tissues.
DR Genevisible; Q8CA71; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026910; Shisa.
DR PANTHER; PTHR31395; PTHR31395; 1.
DR Pfam; PF13908; Shisa; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..197
FT /note="Protein shisa-4"
FT /id="PRO_0000254091"
FT TOPO_DOM 28..87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..197
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 197 AA; 21483 MW; A2E8D109A10DF639 CRC64;
MPPAGPRGTA PLAAVVLLVL GAPLALASED CLWYLDRNGS WHPGFDCEFF TFCCGTCYQR
YCCRDLTLLI TERQQKHCLA FSPKTIAGIA SAVILFVAVV ATTICCFLCS CCYLYRRRQQ
LQSTFEGQEI PMTGIPMQPV YQYPPDPKAG PAPPQPGFMY PPSGPAPQYP LYPAGPPIYN
PAAPPPYMPP QPSYPGA
