ID   SHSA5_BOVIN             Reviewed;         216 AA.
AC   Q3T0A9;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Protein shisa-5;
DE   AltName: Full=Scotin;
DE   Flags: Precursor;
GN   Name=SHISA5; Synonyms=SCOTIN;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Can induce apoptosis in a caspase-dependent manner and plays
CC       a role in p53/TP53-dependent apoptosis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PDCD6; PDCD6 can stabilze SHISA5.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}. Nucleus membrane
CC       {ECO:0000250}.
CC   -!- DOMAIN: The proline-rich region is required for endoplasmic reticulum
CC       localization. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the shisa family. {ECO:0000305}.
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DR   EMBL; BC102472; AAI02473.1; -; mRNA.
DR   RefSeq; NP_001030563.1; NM_001035486.2.
DR   AlphaFoldDB; Q3T0A9; -.
DR   STRING; 9913.ENSBTAP00000012101; -.
DR   Ensembl; ENSBTAT00000078796; ENSBTAP00000057127; ENSBTAG00000009183.
DR   GeneID; 616861; -.
DR   KEGG; bta:616861; -.
DR   CTD; 51246; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009183; -.
DR   VGNC; VGNC:34601; SHISA5.
DR   eggNOG; ENOG502S2Y4; Eukaryota.
DR   GeneTree; ENSGT00390000008296; -.
DR   InParanoid; Q3T0A9; -.
DR   OMA; CPVFCCG; -.
DR   OrthoDB; 1267386at2759; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000009183; Expressed in olfactory segment of nasal mucosa and 103 other tissues.
DR   ExpressionAtlas; Q3T0A9; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
DR   InterPro; IPR026910; Shisa.
DR   PANTHER; PTHR31395; PTHR31395; 1.
DR   Pfam; PF13908; Shisa; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Endoplasmic reticulum; Membrane; Nucleus; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..216
FT                   /note="Protein shisa-5"
FT                   /id="PRO_0000312877"
FT   TOPO_DOM        27..93
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..216
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   216 AA;  23224 MW;  155C54579EE43E65 CRC64;
     MAAPAPAPRI LVLLLLLLPA PEGAQSELCM ISHGRKVDPW VCPDFCCGNC NDQYCCSDVL
     KQVMWIEEDC HAPEASILTD DFDSGFDSDP VARFGTVIAI GVTLFVIAVV TVIVCCTCSC
     CCLYKMCRRP QPVVTTTMAT TVTHTPYLQP PSYPGPTYQG YHSVVPQPGM PTAPYPTQPT
     GPPAYHETMA GGAALPYPAS QPPYNPAYME PPKAVP