ID   SHSA5_CHICK             Reviewed;         139 AA.
AC   Q5ZIS9;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Protein shisa-5;
DE   AltName: Full=Scotin;
GN   Name=Shisa5; Synonyms=Scotin; ORFNames=RCJMB04_23m20;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Can induce apoptosis in a caspase-dependent manner and plays
CC       a role in p53/TP53-dependent apoptosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}. Nucleus membrane
CC       {ECO:0000250}.
CC   -!- DOMAIN: The proline-rich region is required for endoplasmic reticulum
CC       localization. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the shisa family. {ECO:0000305}.
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DR   EMBL; AJ720705; CAG32364.1; -; mRNA.
DR   RefSeq; NP_001025762.1; NM_001030591.2.
DR   AlphaFoldDB; Q5ZIS9; -.
DR   SMR; Q5ZIS9; -.
DR   STRING; 9031.ENSGALP00000007414; -.
DR   PaxDb; Q5ZIS9; -.
DR   GeneID; 415948; -.
DR   KEGG; gga:415948; -.
DR   CTD; 51246; -.
DR   VEuPathDB; HostDB:geneid_415948; -.
DR   eggNOG; ENOG502S2Y4; Eukaryota.
DR   InParanoid; Q5ZIS9; -.
DR   OrthoDB; 1267386at2759; -.
DR   PhylomeDB; Q5ZIS9; -.
DR   PRO; PR:Q5ZIS9; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR026910; Shisa.
DR   PANTHER; PTHR31395; PTHR31395; 1.
DR   Pfam; PF13908; Shisa; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Endoplasmic reticulum; Membrane; Nucleus; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..139
FT                   /note="Protein shisa-5"
FT                   /id="PRO_0000312882"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   139 AA;  14847 MW;  0C38D9E3BDFCCAE8 CRC64;
     MGFGTLVAIG VIVFAVVVIT IILCLTCSCC CLYKACRRPQ PVVTTTTATT VVHAPYPQQQ
     GVPPSYPAAP YQGYQPVAIQ PQPGMPVAPY PAQYPPPYPM QPPDPPAYHE TVAAGAGAPY
     PISQPPYNPA YMDPQKPTY