ID   SHSA5_PONAB             Reviewed;         137 AA.
AC   Q5RDV6;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Protein shisa-5;
DE   AltName: Full=Scotin;
GN   Name=SHISA5; Synonyms=SCOTIN;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Can induce apoptosis in a caspase-dependent manner and plays
CC       a role in p53/TP53-dependent apoptosis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PDCD6; PDCD6 can stabilze SHISA5.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}. Nucleus membrane
CC       {ECO:0000250}.
CC   -!- DOMAIN: The proline-rich region is required for endoplasmic reticulum
CC       localization. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the shisa family. {ECO:0000305}.
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DR   EMBL; CR857788; CAH90051.1; -; mRNA.
DR   RefSeq; NP_001124981.1; NM_001131509.1.
DR   AlphaFoldDB; Q5RDV6; -.
DR   SMR; Q5RDV6; -.
DR   STRING; 9601.ENSPPYP00000015550; -.
DR   PRIDE; Q5RDV6; -.
DR   Ensembl; ENSPPYT00000035961; ENSPPYP00000029785; ENSPPYG00000013902.
DR   GeneID; 100171854; -.
DR   KEGG; pon:100171854; -.
DR   CTD; 51246; -.
DR   eggNOG; ENOG502S2Y4; Eukaryota.
DR   GeneTree; ENSGT00390000008296; -.
DR   InParanoid; Q5RDV6; -.
DR   OrthoDB; 1267386at2759; -.
DR   Proteomes; UP000001595; Chromosome 3.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR026910; Shisa.
DR   PANTHER; PTHR31395; PTHR31395; 1.
DR   Pfam; PF13908; Shisa; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Endoplasmic reticulum; Membrane; Nucleus; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..137
FT                   /note="Protein shisa-5"
FT                   /id="PRO_0000312880"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   137 AA;  14502 MW;  7DB8894F341443AD CRC64;
     MGFGATLAVG LTIFVLSVVT IIICFTCSCC CLYKTCRRPR PVVTTTTSTT VVHAPYPQPP
     SVPPSYPGPS YQGYHTMPPQ PGMPAAPYPM QYPPPYPAQP MGPPAYHETL AGGAAAPYPA
     SQPPYNPAYM DAPKAAL