ID   SHSA5_RAT               Reviewed;         130 AA.
AC   Q5XIH2;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Protein shisa-5;
DE   AltName: Full=Scotin;
GN   Name=Shisa5; Synonyms=Scotin;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Can induce apoptosis in a caspase-dependent manner and plays
CC       a role in p53/TP53-dependent apoptosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}. Nucleus membrane
CC       {ECO:0000250}.
CC   -!- DOMAIN: The proline-rich region is required for endoplasmic reticulum
CC       localization. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the shisa family. {ECO:0000305}.
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DR   EMBL; BC083710; AAH83710.1; -; mRNA.
DR   RefSeq; NP_001006990.1; NM_001006989.1.
DR   AlphaFoldDB; Q5XIH2; -.
DR   STRING; 10116.ENSRNOP00000053045; -.
DR   PaxDb; Q5XIH2; -.
DR   Ensembl; ENSRNOT00000056199; ENSRNOP00000053045; ENSRNOG00000020667.
DR   GeneID; 301013; -.
DR   KEGG; rno:301013; -.
DR   UCSC; RGD:1359661; rat.
DR   CTD; 51246; -.
DR   RGD; 1359661; Shisa5.
DR   eggNOG; ENOG502S2Y4; Eukaryota.
DR   GeneTree; ENSGT00390000008296; -.
DR   HOGENOM; CLU_093192_1_0_1; -.
DR   InParanoid; Q5XIH2; -.
DR   OrthoDB; 1267386at2759; -.
DR   PhylomeDB; Q5XIH2; -.
DR   PRO; PR:Q5XIH2; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000020667; Expressed in spleen and 20 other tissues.
DR   ExpressionAtlas; Q5XIH2; baseline and differential.
DR   Genevisible; Q5XIH2; RN.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; ISO:RGD.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; ISO:RGD.
DR   GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; ISO:RGD.
DR   InterPro; IPR026910; Shisa.
DR   PANTHER; PTHR31395; PTHR31395; 1.
DR   Pfam; PF13908; Shisa; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Endoplasmic reticulum; Membrane; Nucleus; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..130
FT                   /note="Protein shisa-5"
FT                   /id="PRO_0000312881"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          76..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..100
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   130 AA;  13881 MW;  F9D437D83C89A791 CRC64;
     MGFGATVAIG LTVFVVFIAT IIVCFTCSCC CLYKMCCRPR PVVSNTTTTT VVHTAYPQPQ
     PVAPSYPGPT YQGYHPMPPQ PGMPAAPYPT QYPPPYLAQS TGPPAYHETL AGASQPPYNP
     AYMDPPKAVP