SHSA8_HUMAN
ID SHSA8_HUMAN Reviewed; 397 AA.
AC B8ZZ34; A0A087WXQ4;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 3.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Protein shisa-8 {ECO:0000305};
DE AltName: Full=Shisa family member 8 {ECO:0000305};
DE Flags: Precursor;
GN Name=SHISA8 {ECO:0000312|HGNC:HGNC:18351};
GN Synonyms=C22orf17 {ECO:0000312|HGNC:HGNC:18351};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
CC -!- FUNCTION: May regulate trafficking and current kinetics of AMPA-type
CC glutamate receptor (AMPAR) at synapses. {ECO:0000250|UniProtKB:J3QNX5}.
CC -!- SUBUNIT: Interacts with AMPAR subunits GRIA1 and GRIA2.
CC {ECO:0000250|UniProtKB:J3QNX5}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=2;
CC IsoId=B8ZZ34-1; Sequence=Displayed;
CC Name=1;
CC IsoId=B8ZZ34-3; Sequence=VSP_059385;
CC -!- SIMILARITY: Belongs to the shisa family. {ECO:0000305}.
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DR EMBL; Z99716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS74872.1; -. [B8ZZ34-1]
DR RefSeq; NP_001193949.1; NM_001207020.1. [B8ZZ34-1]
DR RefSeq; XP_006724317.1; XM_006724254.3.
DR AlphaFoldDB; B8ZZ34; -.
DR SMR; B8ZZ34; -.
DR BioGRID; 136928; 2.
DR STRING; 9606.ENSP00000481203; -.
DR TCDB; 8.A.83.1.2; the shisa6 regulator of short-term neuronal synaptic plasticity (shisa) family.
DR GlyGen; B8ZZ34; 1 site.
DR PhosphoSitePlus; B8ZZ34; -.
DR BioMuta; SHISA8; -.
DR jPOST; B8ZZ34; -.
DR MassIVE; B8ZZ34; -.
DR PaxDb; B8ZZ34; -.
DR PeptideAtlas; B8ZZ34; -.
DR PRIDE; B8ZZ34; -.
DR ProteomicsDB; 7297; -.
DR Antibodypedia; 71661; 4 antibodies from 4 providers.
DR DNASU; 440829; -.
DR Ensembl; ENST00000621082.2; ENSP00000481203.1; ENSG00000234965.3. [B8ZZ34-1]
DR GeneID; 440829; -.
DR KEGG; hsa:440829; -.
DR MANE-Select; ENST00000621082.2; ENSP00000481203.1; NM_001207020.3; NP_001193949.1.
DR UCSC; uc062esx.1; human. [B8ZZ34-1]
DR CTD; 440829; -.
DR DisGeNET; 440829; -.
DR GeneCards; SHISA8; -.
DR HGNC; HGNC:18351; SHISA8.
DR HPA; ENSG00000234965; Group enriched (adrenal gland, brain).
DR MIM; 617329; gene.
DR neXtProt; NX_B8ZZ34; -.
DR OpenTargets; ENSG00000234965; -.
DR PharmGKB; PA165378367; -.
DR VEuPathDB; HostDB:ENSG00000234965; -.
DR eggNOG; ENOG502R5Y2; Eukaryota.
DR GeneTree; ENSGT00940000163233; -.
DR HOGENOM; CLU_083907_2_1_1; -.
DR InParanoid; B8ZZ34; -.
DR OMA; INASQMP; -.
DR OrthoDB; 558642at2759; -.
DR PathwayCommons; B8ZZ34; -.
DR BioGRID-ORCS; 440829; 7 hits in 243 CRISPR screens.
DR ChiTaRS; SHISA8; human.
DR GenomeRNAi; 440829; -.
DR Pharos; B8ZZ34; Tdark.
DR PRO; PR:B8ZZ34; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; B8ZZ34; protein.
DR Bgee; ENSG00000234965; Expressed in right hemisphere of cerebellum and 78 other tissues.
DR ExpressionAtlas; B8ZZ34; baseline and differential.
DR GO; GO:0032281; C:AMPA glutamate receptor complex; IBA:GO_Central.
DR GO; GO:0032591; C:dendritic spine membrane; IBA:GO_Central.
DR GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IBA:GO_Central.
DR GO; GO:2000311; P:regulation of AMPA receptor activity; IBA:GO_Central.
DR GO; GO:0048172; P:regulation of short-term neuronal synaptic plasticity; IBA:GO_Central.
DR InterPro; IPR026910; Shisa.
DR PANTHER; PTHR31774; PTHR31774; 1.
DR Pfam; PF13908; Shisa; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..38
FT /evidence="ECO:0000255"
FT CHAIN 39..397
FT /note="Protein shisa-8"
FT /id="PRO_0000395039"
FT TOPO_DOM 39..138
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..397
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 117..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..303
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 221
FT /note="A -> AGPRTPRLARASPPGEPFMRVAPPGLAAAAAARDSEPGPVPGAGGCG
FT EDRLGSQPRPENGPPGSHRTASGRGLRRGDSEGGVNRGIGPSRVSLLAP (in
FT isoform 1)"
FT /id="VSP_059385"
SQ SEQUENCE 397 AA; 41995 MW; A24436A7290A0E15 CRC64;
MARAGARGLL GGRRPPGLRL ALALRLALLL ARPPSGRAGA PEAQGPAAPG TTAPEGGDRC
RGYYDVMGQW DPPFNCSSGA YSFCCGTCGY RFCCHDGPRR LDQSRCSNYD TPAWVQTGRP
PARARDTAAP RDPGRERSHT AVYAVCGVAA LLVLAGIGAR LGLERAHSPR ARRTVTRALT
ELLKQPGPQE PLPPTLGPPL GGCVQVQMGD GLPRGSPHNS ADKKRLNNAP RGSAAPGPPR
GPRLQGGGSL TLQPDYAKYA TFKAAALKAA EAAPRDFCQR FPALEPSPRQ PPARAPRPSP
DLPAPLDACP WAPPVYAPPA APGPYAAWTS SRPARPAPLS HPTARAFQVP RRPGHAARRQ
FSVKMPETFN PQLPGLYGSA GRGSRYLRTN SKTEVTV
