ID   SHSA9_XENTR             Reviewed;         390 AA.
AC   A7MC48;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Protein shisa-9;
DE   Flags: Precursor;
GN   Name=shisa9;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of short-term neuronal synaptic plasticity in the
CC       dentate gyrus. Associates with AMPA receptors (ionotropic glutamate
CC       receptors) in synaptic spines and promotes AMPA receptor
CC       desensitization at excitatory synapses (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of some AMPA receptors (ionotropic glutamate
CC       receptors) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, dendritic spine membrane
CC       {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC       Synapse {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the shisa family. SHISA9 subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI52043.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC152042; AAI52043.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001106396.1; NM_001112925.1.
DR   AlphaFoldDB; A7MC48; -.
DR   SMR; A7MC48; -.
DR   STRING; 8364.ENSXETP00000053357; -.
DR   GeneID; 100127547; -.
DR   KEGG; xtr:100127547; -.
DR   CTD; 729993; -.
DR   Xenbase; XB-GENE-955578; shisa9.
DR   InParanoid; A7MC48; -.
DR   OrthoDB; 659452at2759; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000034623; Expressed in brain and 1 other tissue.
DR   GO; GO:0032281; C:AMPA glutamate receptor complex; IBA:GO_Central.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0032591; C:dendritic spine membrane; ISS:UniProtKB.
DR   GO; GO:0008328; C:ionotropic glutamate receptor complex; ISS:UniProtKB.
DR   GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR   GO; GO:0045211; C:postsynaptic membrane; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; ISS:UniProtKB.
DR   GO; GO:2000311; P:regulation of AMPA receptor activity; IBA:GO_Central.
DR   GO; GO:0048172; P:regulation of short-term neuronal synaptic plasticity; ISS:UniProtKB.
DR   InterPro; IPR026910; Shisa.
DR   PANTHER; PTHR31774; PTHR31774; 1.
DR   Pfam; PF13908; Shisa; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Glycoprotein; Membrane;
KW   Postsynaptic cell membrane; Reference proteome; Signal; Synapse;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..390
FT                   /note="Protein shisa-9"
FT                   /id="PRO_0000394257"
FT   TOPO_DOM        23..134
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        156..390
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        40
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        74
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   390 AA;  43824 MW;  5D7D1C62FEA32581 CRC64;
     MTGIRAIFYY FLVDLLTLLC WAQGKGGQHF GSTVVVSDVN LSNHGDQGSS EPPQTAEGCR
     GYFDVMGQWD PPFNCSSGEF LYCCGTCGFR YCCKFKQARL DQNTCTNYDR PVWLQPGKTP
     PKIDDPSHDP TRDKTNLIVY IICGVVAVMV LVGIFTKLGL EKAHRPQREN MSRALADVMR
     QQSHCATEHT ERDPNLVIHV QHYETMPSRS SANNLHSSKI NNVVPTSPHL PQMAHPHSYP
     TMGQISNPYE QQPPGKELNK YASLKAVAEK GNDDFYSKRR HLAELAAKGS LPLHPVRVDQ
     ERSYSPEGGT LKVNGQKAKA NKIHTHPLAS TYNPDYKTWD HSEHSLRRQA YATKKHCPVE
     SVNEPLQSQN QHFMPSQPYF VTNSKTEVTV