ID   SHSL1_MOUSE             Reviewed;         198 AA.
AC   Q0VBP7; Q6P5D2; Q6ZPK6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Protein shisa-like-1;
DE   Flags: Precursor;
GN   Name=Shisal1; Synonyms=Kiaa1644;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA   Saga Y., Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT   The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 10:167-180(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the shisa family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC98225.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK129415; BAC98225.2; ALT_INIT; Transcribed_RNA.
DR   EMBL; BC062953; AAH62953.2; -; mRNA.
DR   EMBL; BC119234; AAI19235.1; -; mRNA.
DR   EMBL; BC120551; AAI20552.1; -; mRNA.
DR   CCDS; CCDS49687.1; -.
DR   RefSeq; NP_001156617.1; NM_001163145.1.
DR   AlphaFoldDB; Q0VBP7; -.
DR   SMR; Q0VBP7; -.
DR   STRING; 10090.ENSMUSP00000079575; -.
DR   GlyGen; Q0VBP7; 2 sites.
DR   PhosphoSitePlus; Q0VBP7; -.
DR   PaxDb; Q0VBP7; -.
DR   PRIDE; Q0VBP7; -.
DR   ProteomicsDB; 257013; -.
DR   Antibodypedia; 53815; 64 antibodies from 15 providers.
DR   Ensembl; ENSMUST00000080751; ENSMUSP00000079575; ENSMUSG00000062760.
DR   GeneID; 72301; -.
DR   KEGG; mmu:72301; -.
DR   CTD; 85352; -.
DR   MGI; MGI:1919551; Shisal1.
DR   VEuPathDB; HostDB:ENSMUSG00000062760; -.
DR   eggNOG; ENOG502R0N8; Eukaryota.
DR   GeneTree; ENSGT00390000006791; -.
DR   InParanoid; Q0VBP7; -.
DR   OMA; ICRVYLA; -.
DR   PhylomeDB; Q0VBP7; -.
DR   BioGRID-ORCS; 72301; 2 hits in 71 CRISPR screens.
DR   ChiTaRS; 1810041L15Rik; mouse.
DR   PRO; PR:Q0VBP7; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; Q0VBP7; protein.
DR   Bgee; ENSMUSG00000062760; Expressed in habenula and 160 other tissues.
DR   ExpressionAtlas; Q0VBP7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026910; Shisa.
DR   PANTHER; PTHR31395; PTHR31395; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..198
FT                   /note="Protein shisa-like-1"
FT                   /id="PRO_0000318952"
FT   TOPO_DOM        25..96
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        118..198
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          145..198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        155..173
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   198 AA;  22482 MW;  31F270096A928A54 CRC64;
     MTSCGQRSRN VLAVFSLLFP AVLSAHFRVC EPYTDHKGRY HFGFHCPRLS DNKTFVLCCH
     HNNTVFKYCC NETEFQAVMQ ANLTAGPEGY MHNNYTALLG VWIYGFFVLT LLVLDLLYYS
     AMNYDICKVY LTRWGIQGRW MKQDPRRWGN PARAPRPGQP APQPQPPPGT LPQAPQAVHT
     LRGDTHSPPL MTFQSSSA