ID   SHT1_HOMDU              Reviewed;          29 AA.
AC   C0HJB4;
DT   24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2013, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=U-homostoxin-Hdu1a {ECO:0000305};
DE            Short=U-HMTX-Hdu1a {ECO:0000305};
DE   AltName: Full=Peptide U-SHTX-Sdd1 {ECO:0000303|PubMed:23727489};
OS   Homostichanthus duerdeni (Sea anemone) (Stichodactyla duerdeni).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Homostichanthidae; Homostichanthus.
OX   NCBI_TaxID=1301368;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AND
RP   GLYCOSYLATION AT THR-1.
RX   PubMed=23727489; DOI=10.1016/j.jprot.2013.05.022;
RA   Cassoli J.S., Verano-Braga T., de Oliveira J.S., Montandon G.G.,
RA   Cologna C.T., Peigneur S., de Castro Pimenta A.M., Kjeldsen F.,
RA   Roepstorff P., Tytgat J., de Lima M.E.;
RT   "The proteomic profile of Stichodactyla duerdeni secretion reveals the
RT   presence of a novel O-linked glycopeptide.";
RL   J. Proteomics 87:89-102(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23727489}.
CC       Nematocyst {ECO:0000250|UniProtKB:P0C7W7}.
CC   -!- MASS SPECTROMETRY: Mass=3431.16; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:23727489};
CC   -!- MISCELLANEOUS: Does not inhibit voltage-gated potassium channels
CC       rKv1.1/KCNA1, rKv1.2/KCNA2, rKv1.3/KCNA3, rKv1.4/KCNA4, rKv1.5/KCNA5
CC       rKv1.6/KCNA6, Shaker IR (with inactivation domain removed),
CC       rKv2.1/KCNB1, hKv3.1/KCNC1, rKv4.3/KCND3 and hERG.
CC       {ECO:0000269|PubMed:23727489}.
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DR   AlphaFoldDB; C0HJB4; -.
DR   SMR; C0HJB4; -.
DR   TCDB; 8.B.15.1.2; the sea anemone peptide toxin class 4 (shtx) family.
DR   iPTMnet; C0HJB4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Nematocyst;
KW   Secreted; Toxin.
FT   PEPTIDE         1..29
FT                   /note="U-homostoxin-Hdu1a"
FT                   /evidence="ECO:0000269|PubMed:23727489"
FT                   /id="PRO_0000423182"
FT   CARBOHYD        1
FT                   /note="O-linked (GlcNAc...) threonine"
FT                   /evidence="ECO:0000269|PubMed:23727489"
FT   DISULFID        7..19
FT                   /evidence="ECO:0000250|UniProtKB:P0C7W7"
FT   DISULFID        10..25
FT                   /evidence="ECO:0000250|UniProtKB:P0C7W7"
SQ   SEQUENCE   29 AA;  3234 MW;  5CC6857BB876968E CRC64;
     TIIGAPCRKC EHLDRSGNCV RDWSCGQEV