SHU1_YEAST
ID SHU1_YEAST Reviewed; 150 AA.
AC P38751; D3DKQ9; Q07190;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 30-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Suppressor of HU sensitivity involved in recombination protein 1;
GN Name=SHU1; OrderedLocusNames=YHL006C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091229; DOI=10.1126/science.8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA Waterston R., Wilson R., Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [2]
RP SEQUENCE REVISION TO C-TERMINUS.
RA Fisk D., Cherry J.M.;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Dignard D.;
RL Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION IN THE SHU COMPLEX, SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=15654096; DOI=10.1534/genetics.104.036764;
RA Shor E., Weinstein J., Rothstein R.;
RT "A genetic screen for top3 suppressors in Saccharomyces cerevisiae
RT identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA
RT repair.";
RL Genetics 169:1275-1289(2005).
RN [6]
RP IDENTIFICATION IN THE SHU COMPLEX, AND FUNCTION.
RX PubMed=19496932; DOI=10.1111/j.1365-2958.2009.06748.x;
RA Ball L.G., Zhang K., Cobb J.A., Boone C., Xiao W.;
RT "The yeast Shu complex couples error-free post-replication repair to
RT homologous recombination.";
RL Mol. Microbiol. 73:89-102(2009).
CC -!- FUNCTION: Plays a role in a RAD51/RAD54-dependent homologous
CC recombination repair (HRR) pathway to repair MMS-induced lesions during
CC S-phase. {ECO:0000269|PubMed:15654096, ECO:0000269|PubMed:19496932}.
CC -!- SUBUNIT: Component of the SHU complex composed of at least CSM2, PSY3,
CC SHU1 and SHU2. {ECO:0000269|PubMed:15654096,
CC ECO:0000269|PubMed:19496932}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15654096}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA35196.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U11581; AAB69748.2; -; Genomic_DNA.
DR EMBL; L09261; AAA35196.1; ALT_FRAME; Genomic_DNA.
DR EMBL; BK006934; DAA06682.1; -; Genomic_DNA.
DR PIR; S46822; S46822.
DR RefSeq; NP_011857.2; NM_001179086.1.
DR PDB; 5XYN; X-ray; 3.30 A; C=1-150.
DR PDBsum; 5XYN; -.
DR AlphaFoldDB; P38751; -.
DR SMR; P38751; -.
DR BioGRID; 36420; 79.
DR ComplexPortal; CPX-3087; Shu complex.
DR DIP; DIP-1874N; -.
DR IntAct; P38751; 7.
DR MINT; P38751; -.
DR STRING; 4932.YHL006C; -.
DR PaxDb; P38751; -.
DR PRIDE; P38751; -.
DR EnsemblFungi; YHL006C_mRNA; YHL006C; YHL006C.
DR GeneID; 856383; -.
DR KEGG; sce:YHL006C; -.
DR SGD; S000000998; SHU1.
DR VEuPathDB; FungiDB:YHL006C; -.
DR HOGENOM; CLU_1741621_0_0_1; -.
DR InParanoid; P38751; -.
DR OMA; LQYLFMY; -.
DR BioCyc; YEAST:G3O-31028-MON; -.
DR ChiTaRS; SHU1; yeast.
DR PRO; PR:P38751; -.
DR Proteomes; UP000002311; Chromosome VIII.
DR RNAct; P38751; protein.
DR GO; GO:0005730; C:nucleolus; IDA:SGD.
DR GO; GO:0097196; C:Shu complex; IDA:SGD.
DR GO; GO:0035861; C:site of double-strand break; IMP:SGD.
DR GO; GO:0000730; P:DNA recombinase assembly; IMP:SGD.
DR GO; GO:0042275; P:error-free postreplication DNA repair; IC:ComplexPortal.
DR GO; GO:0043007; P:maintenance of rDNA; IGI:SGD.
DR GO; GO:1903112; P:positive regulation of single-strand break repair via homologous recombination; IC:ComplexPortal.
DR GO; GO:0000725; P:recombinational repair; IMP:SGD.
PE 1: Evidence at protein level;
KW 3D-structure; DNA damage; DNA recombination; DNA repair; Nucleus;
KW Reference proteome.
FT CHAIN 1..150
FT /note="Suppressor of HU sensitivity involved in
FT recombination protein 1"
FT /id="PRO_0000097742"
FT CONFLICT 138
FT /note="P -> A (in Ref. 4; AAA35196)"
FT /evidence="ECO:0000305"
FT HELIX 3..11
FT /evidence="ECO:0007829|PDB:5XYN"
FT STRAND 24..30
FT /evidence="ECO:0007829|PDB:5XYN"
FT HELIX 31..38
FT /evidence="ECO:0007829|PDB:5XYN"
FT TURN 39..45
FT /evidence="ECO:0007829|PDB:5XYN"
FT HELIX 51..59
FT /evidence="ECO:0007829|PDB:5XYN"
FT STRAND 61..66
FT /evidence="ECO:0007829|PDB:5XYN"
FT HELIX 69..81
FT /evidence="ECO:0007829|PDB:5XYN"
FT STRAND 83..85
FT /evidence="ECO:0007829|PDB:5XYN"
FT STRAND 89..95
FT /evidence="ECO:0007829|PDB:5XYN"
FT HELIX 96..99
FT /evidence="ECO:0007829|PDB:5XYN"
FT HELIX 105..119
FT /evidence="ECO:0007829|PDB:5XYN"
FT STRAND 122..130
FT /evidence="ECO:0007829|PDB:5XYN"
FT HELIX 137..149
FT /evidence="ECO:0007829|PDB:5XYN"
SQ SEQUENCE 150 AA; 17121 MW; 8B17700BDAA2367F CRC64;
MQFEERLQQL VESDWSLDQS SPNVLVIVLG DTARKYVELG GLKEHVTTNT VAGHVASRER
VSVVFLGRVK YLYMYLTRMQ AQANGPQYSN VLVYGLWDLT ATQDGPQQLR LLSLVLRQCL
SLPSKVEFYP EPPSSSVPAR LLRFWDHIIR
