ID   SHU2_ASHGO              Reviewed;         201 AA.
AC   Q74ZQ8;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Suppressor of hydroxyurea sensitivity protein 2;
GN   Name=SHU2; OrderedLocusNames=AGR140C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Plays a role in a RAD51/RAD54-dependent homologous
CC       recombination repair (HRR) pathway to repair MMS-induced lesions during
CC       S-phase. Required for error-free repair of spontaneous and induced DNA
CC       lesions to protect the genome from mutation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHU2 family. {ECO:0000305}.
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DR   EMBL; AE016820; AAS54630.1; -; Genomic_DNA.
DR   RefSeq; NP_986806.1; NM_211868.1.
DR   PDB; 6DEX; X-ray; 2.10 A; B=1-201.
DR   PDBsum; 6DEX; -.
DR   AlphaFoldDB; Q74ZQ8; -.
DR   SMR; Q74ZQ8; -.
DR   STRING; 33169.AAS54630; -.
DR   EnsemblFungi; AAS54630; AAS54630; AGOS_AGR140C.
DR   GeneID; 4623108; -.
DR   KEGG; ago:AGOS_AGR140C; -.
DR   eggNOG; ENOG502S0XB; Eukaryota.
DR   HOGENOM; CLU_1115918_0_0_1; -.
DR   InParanoid; Q74ZQ8; -.
DR   OMA; WLKLHLN; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; DNA damage; DNA recombination; DNA repair; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..201
FT                   /note="Suppressor of hydroxyurea sensitivity protein 2"
FT                   /id="PRO_0000409731"
FT   HELIX           8..13
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   HELIX           24..33
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   HELIX           38..46
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   TURN            47..49
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   STRAND          51..56
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   HELIX           63..72
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   STRAND          77..81
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   STRAND          84..87
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   STRAND          91..94
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   HELIX           95..97
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   HELIX           103..109
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   HELIX           110..112
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   HELIX           119..123
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   STRAND          124..130
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   STRAND          143..147
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   TURN            149..151
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   HELIX           155..164
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   HELIX           168..175
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   STRAND          182..187
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   HELIX           190..196
FT                   /evidence="ECO:0007829|PDB:6DEX"
FT   TURN            197..200
FT                   /evidence="ECO:0007829|PDB:6DEX"
SQ   SEQUENCE   201 AA;  22893 MW;  397D1465255D3CA5 CRC64;
     MAETNFNYSK LLRNLVTEDN VLNEVVVSFL YQLFPRDLFV RAFSLLESAD MFIYVWMPTP
     KEADELLESL YNGTPLYRPI VRPRGPDDRP VCVDLDHWFC SCTEFAATCR PHLVGDTPLS
     DALFRPTEAA DPDDCFGMLA GLQHLRADPE KLMCEHLFAF AILLQTDLRV LRHFSTGPGA
     QVFVLGITSI DEWLKLHLNV V