ID   SHU2_CANGA              Reviewed;         255 AA.
AC   Q6FM84;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Suppressor of hydroxyurea sensitivity protein 2;
GN   Name=SHU2; OrderedLocusNames=CAGL0K10142g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Plays a role in a RAD51/RAD54-dependent homologous
CC       recombination repair (HRR) pathway to repair MMS-induced lesions during
CC       S-phase. Required for error-free repair of spontaneous and induced DNA
CC       lesions to protect the genome from mutation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHU2 family. {ECO:0000305}.
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DR   EMBL; CR380957; CAG61623.1; -; Genomic_DNA.
DR   RefSeq; XP_448660.1; XM_448660.1.
DR   AlphaFoldDB; Q6FM84; -.
DR   SMR; Q6FM84; -.
DR   STRING; 5478.XP_448660.1; -.
DR   EnsemblFungi; CAG61623; CAG61623; CAGL0K10142g.
DR   GeneID; 2890110; -.
DR   KEGG; cgr:CAGL0K10142g; -.
DR   CGD; CAL0134723; CAGL0K10142g.
DR   VEuPathDB; FungiDB:CAGL0K10142g; -.
DR   eggNOG; ENOG502S0XB; Eukaryota.
DR   HOGENOM; CLU_1115918_0_0_1; -.
DR   InParanoid; Q6FM84; -.
DR   OMA; WLKLHLN; -.
DR   Proteomes; UP000002428; Chromosome K.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0097196; C:Shu complex; IEA:EnsemblFungi.
DR   GO; GO:0035861; C:site of double-strand break; IEA:EnsemblFungi.
DR   GO; GO:0000730; P:DNA recombinase assembly; IEA:EnsemblFungi.
DR   GO; GO:0043007; P:maintenance of rDNA; IEA:EnsemblFungi.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Nucleus; Reference proteome.
FT   CHAIN           1..255
FT                   /note="Suppressor of hydroxyurea sensitivity protein 2"
FT                   /id="PRO_0000409732"
SQ   SEQUENCE   255 AA;  29130 MW;  F3E1B6578733D6DB CRC64;
     MNEDASVINY SEIFSTLVKD DGVDDMVASF LYYMFPRELF IRGLSLLESS DMFIYVFDAM
     KGESSESEVN TDVDTSVNLS SKENIATSTT ATQINAKDNS VDVTKNYLNK LYEDDDLLQY
     RLIVKSSSSD GIETPVYVDL HNWLCSCEEY TEIMRECLLA DKDLVQEFVQ LIDDFSCFRD
     DTFGQIEAHS LSLQKYVNTK KLLCPHLLAY SIILLSSPKV LRHYTVEKPG VIVIPITSID
     EWLKLHINVL YSEKK