ID   SHU2_LACTC              Reviewed;         249 AA.
AC   C5E2S6;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Suppressor of hydroxyurea sensitivity protein 2;
GN   Name=SHU2; OrderedLocusNames=KLTH0H07348g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Plays a role in a RAD51/RAD54-dependent homologous
CC       recombination repair (HRR) pathway to repair MMS-induced lesions during
CC       S-phase. Required for error-free repair of spontaneous and induced DNA
CC       lesions to protect the genome from mutation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHU2 family. {ECO:0000305}.
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DR   EMBL; CU928180; CAR30337.1; -; Genomic_DNA.
DR   RefSeq; XP_002556199.1; XM_002556153.1.
DR   AlphaFoldDB; C5E2S6; -.
DR   SMR; C5E2S6; -.
DR   STRING; 559295.C5E2S6; -.
DR   EnsemblFungi; CAR30337; CAR30337; KLTH0H07348g.
DR   GeneID; 8294516; -.
DR   KEGG; lth:KLTH0H07348g; -.
DR   eggNOG; ENOG502S0XB; Eukaryota.
DR   HOGENOM; CLU_1115918_0_0_1; -.
DR   InParanoid; C5E2S6; -.
DR   OMA; WLKLHLN; -.
DR   OrthoDB; 1496065at2759; -.
DR   Proteomes; UP000002036; Chromosome H.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Nucleus; Reference proteome.
FT   CHAIN           1..249
FT                   /note="Suppressor of hydroxyurea sensitivity protein 2"
FT                   /id="PRO_0000409734"
FT   REGION          68..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   249 AA;  28279 MW;  2E334D50101DB7FE CRC64;
     MVDEHYIDYS QLLAQLLDKD GELNETTVSF LYHLFPSDFF VRAMSLIDSN NMFIYVFERD
     ETSAALTTSV GTEPDEVETT TETLRTSPSP PVASEQELGN AVQSSALINT LYEKPQSVLH
     RLIVKQEGPQ SPPVCVDLRH WFCSCDEYNT LFEERMLTDE EPSLYSKATT ELRAGASITD
     SFASMPPKGA SRRYFRHDII MCPHLLAFAI LLQTTPELLT YFTHKAATVY LITIQNLDEW
     LKLHLNVVI