ID   SHU2_VANPO              Reviewed;         248 AA.
AC   A7TGA7;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Suppressor of hydroxyurea sensitivity protein 2;
GN   Name=SHU2; ORFNames=Kpol_1055p32;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Plays a role in a RAD51/RAD54-dependent homologous
CC       recombination repair (HRR) pathway to repair MMS-induced lesions during
CC       S-phase. Required for error-free repair of spontaneous and induced DNA
CC       lesions to protect the genome from mutation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHU2 family. {ECO:0000305}.
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DR   EMBL; DS480386; EDO18677.1; -; Genomic_DNA.
DR   RefSeq; XP_001646535.1; XM_001646485.1.
DR   AlphaFoldDB; A7TGA7; -.
DR   SMR; A7TGA7; -.
DR   STRING; 436907.A7TGA7; -.
DR   EnsemblFungi; EDO18677; EDO18677; Kpol_1055p32.
DR   GeneID; 5546982; -.
DR   KEGG; vpo:Kpol_1055p32; -.
DR   eggNOG; ENOG502S0XB; Eukaryota.
DR   HOGENOM; CLU_1115918_0_0_1; -.
DR   InParanoid; A7TGA7; -.
DR   OMA; WLKLHLN; -.
DR   OrthoDB; 1496065at2759; -.
DR   PhylomeDB; A7TGA7; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Nucleus; Reference proteome.
FT   CHAIN           1..248
FT                   /note="Suppressor of hydroxyurea sensitivity protein 2"
FT                   /id="PRO_0000409735"
FT   REGION          73..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   248 AA;  28557 MW;  A040B0B196D8DB7A CRC64;
     MDTNKSVIYS QFFSKLINDN NEMDDTMTSF LYYLFPRELF IRALSLLDSG DMFIYVLENG
     NISSSSMNLV PTVCDSDESR SPSSSGNSNN EASNESNTID SNSIVEELYD IDTELQNRLI
     VKTHEKDSPP IYVDLKTWFC SCDEFNSYFN LELQKNQSIP IQDTLIRNID DIQEFSEDKF
     AQIDAHSLSK QKYVCHEKLM CPHLLAYSIL LASSTKTLRY FTLVNQTVLL IRISNMDEWL
     KLHINIVS