ID   SHU2_YEAS2              Reviewed;         223 AA.
AC   C7GVQ9;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Suppressor of hydroxyurea sensitivity protein 2;
GN   Name=SHU2; ORFNames=C1Q_04575;
OS   Saccharomyces cerevisiae (strain JAY291) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=574961;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JAY291;
RX   PubMed=19812109; DOI=10.1101/gr.091777.109;
RA   Argueso J.L., Carazzolle M.F., Mieczkowski P.A., Duarte F.M., Netto O.V.C.,
RA   Missawa S.K., Galzerani F., Costa G.G.L., Vidal R.O., Noronha M.F.,
RA   Dominska M., Andrietta M.G.S., Andrietta S.R., Cunha A.F., Gomes L.H.,
RA   Tavares F.C.A., Alcarde A.R., Dietrich F.S., McCusker J.H., Petes T.D.,
RA   Pereira G.A.G.;
RT   "Genome structure of a Saccharomyces cerevisiae strain widely used in
RT   bioethanol production.";
RL   Genome Res. 19:2258-2270(2009).
CC   -!- FUNCTION: Plays a role in a RAD51/RAD54-dependent homologous
CC       recombination repair (HRR) pathway to repair MMS-induced lesions during
CC       S-phase. Required for error-free repair of spontaneous and induced DNA
CC       lesions to protect the genome from mutation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SHU complex composed of at least CSM2, PSY3,
CC       SHU1 and SHU2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHU2 family. {ECO:0000305}.
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DR   EMBL; ACFL01000358; EEU05127.1; -; Genomic_DNA.
DR   AlphaFoldDB; C7GVQ9; -.
DR   SMR; C7GVQ9; -.
DR   Proteomes; UP000008073; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Nucleus.
FT   CHAIN           1..223
FT                   /note="Suppressor of hydroxyurea sensitivity protein 2"
FT                   /id="PRO_0000409737"
SQ   SEQUENCE   223 AA;  26123 MW;  A02B8EBF38FC4423 CRC64;
     MSKDVIEYSK LFAKLVNTND DTKLDDTIAS FLYYMFPREL FIRAISLLES SDMFIYILDR
     VHNKEGNEHT SLIDVLVDEF YKGSSNSLLE YRLIVKDTND GAPPILVDIA HWFCSCEEFC
     KYFHEALEKT DEKEELHDVL INEVDDHLQF SDDRFAQLDP HSLSKQWYFK FDKVCCSHLL
     AFSILLRSSI NVLKFFTVNS NKVFVIAIDN IDEWLNLHIN IVE