ID   SHU2_YEAS7              Reviewed;         223 AA.
AC   A6ZY43;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Suppressor of hydroxyurea sensitivity protein 2;
GN   Name=SHU2; ORFNames=SCY_0981;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Plays a role in a RAD51/RAD54-dependent homologous
CC       recombination repair (HRR) pathway to repair MMS-induced lesions during
CC       S-phase. Required for error-free repair of spontaneous and induced DNA
CC       lesions to protect the genome from mutation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SHU complex composed of at least CSM2, PSY3,
CC       SHU1 and SHU2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHU2 family. {ECO:0000305}.
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DR   EMBL; AAFW02000145; EDN60423.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZY43; -.
DR   SMR; A6ZY43; -.
DR   EnsemblFungi; EDN60423; EDN60423; SCY_0981.
DR   HOGENOM; CLU_1115918_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Nucleus.
FT   CHAIN           1..223
FT                   /note="Suppressor of hydroxyurea sensitivity protein 2"
FT                   /id="PRO_0000409739"
SQ   SEQUENCE   223 AA;  26137 MW;  A03C85D2992C4423 CRC64;
     MSKDVIEYSK LFAKLVNTND DTKLDDTIAS FLYYMFPREL FIRAISLLES SDMFIYILDR
     VHNKEGNEHT SLIDVLVDEF YKGSSNSLLE YRLIVKDTND GAPPILVDIA HWFCSCEEFC
     KYFHEALEKT DEKEELHDVL INEVDDHLQF SDDRFAQLDP HSLSKQWYFK FDKICCSHLL
     AFSILLRSSI NVLKFFTVNS NKVFVIAIDN IDEWLNLHIN IVE