ID   SHU2_YEAS8              Reviewed;         223 AA.
AC   C8Z4Z5;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Suppressor of hydroxyurea sensitivity protein 2;
GN   Name=SHU2; ORFNames=EC1118_1D0_3257g;
OS   Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's
OS   yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=643680;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lalvin EC1118 / Prise de mousse;
RX   PubMed=19805302; DOI=10.1073/pnas.0904673106;
RA   Novo M., Bigey F., Beyne E., Galeote V., Gavory F., Mallet S., Cambon B.,
RA   Legras J.-L., Wincker P., Casaregola S., Dequin S.;
RT   "Eukaryote-to-eukaryote gene transfer events revealed by the genome
RT   sequence of the wine yeast Saccharomyces cerevisiae EC1118.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:16333-16338(2009).
CC   -!- FUNCTION: Plays a role in a RAD51/RAD54-dependent homologous
CC       recombination repair (HRR) pathway to repair MMS-induced lesions during
CC       S-phase. Required for error-free repair of spontaneous and induced DNA
CC       lesions to protect the genome from mutation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SHU complex composed of at least CSM2, PSY3,
CC       SHU1 and SHU2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHU2 family. {ECO:0000305}.
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DR   EMBL; FN393063; CAY78584.1; -; Genomic_DNA.
DR   AlphaFoldDB; C8Z4Z5; -.
DR   SMR; C8Z4Z5; -.
DR   EnsemblFungi; CAY78584; CAY78584; EC1118_1D0_3257g.
DR   HOGENOM; CLU_1115918_0_0_1; -.
DR   Proteomes; UP000000286; Chromosome IV, Scaffold EC1118_1D0.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Nucleus.
FT   CHAIN           1..223
FT                   /note="Suppressor of hydroxyurea sensitivity protein 2"
FT                   /id="PRO_0000409740"
SQ   SEQUENCE   223 AA;  26137 MW;  A03C85D2992C4423 CRC64;
     MSKDVIEYSK LFAKLVNTND DTKLDDTIAS FLYYMFPREL FIRAISLLES SDMFIYILDR
     VHNKEGNEHT SLIDVLVDEF YKGSSNSLLE YRLIVKDTND GAPPILVDIA HWFCSCEEFC
     KYFHEALEKT DEKEELHDVL INEVDDHLQF SDDRFAQLDP HSLSKQWYFK FDKICCSHLL
     AFSILLRSSI NVLKFFTVNS NKVFVIAIDN IDEWLNLHIN IVE