SHU2_YEASV
ID SHU2_YEASV Reviewed; 223 AA.
AC E7LSL5;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 25-MAY-2022, entry version 24.
DE RecName: Full=Suppressor of hydroxyurea sensitivity protein 2;
GN Name=SHU2; ORFNames=VIN13_0811;
OS Saccharomyces cerevisiae (strain VIN 13) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=764099;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VIN 13;
RX PubMed=21304888; DOI=10.1371/journal.pgen.1001287;
RA Borneman A.R., Desany B.A., Riches D., Affourtit J.P., Forgan A.H.,
RA Pretorius I.S., Egholm M., Chambers P.J.;
RT "Whole-genome comparison reveals novel genetic elements that characterize
RT the genome of industrial strains of Saccharomyces cerevisiae.";
RL PLoS Genet. 7:E1001287-E1001287(2011).
CC -!- FUNCTION: Plays a role in a RAD51/RAD54-dependent homologous
CC recombination repair (HRR) pathway to repair MMS-induced lesions during
CC S-phase. Required for error-free repair of spontaneous and induced DNA
CC lesions to protect the genome from mutation (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the SHU complex composed of at least CSM2, PSY3,
CC SHU1 and SHU2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SHU2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADXC01000018; EGA79557.1; -; Genomic_DNA.
DR AlphaFoldDB; E7LSL5; -.
DR SMR; E7LSL5; -.
DR EnsemblFungi; EGA79557; EGA79557; VIN13_0811.
DR HOGENOM; CLU_1115918_0_0_1; -.
DR OMA; WLKLHLN; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW DNA damage; DNA recombination; DNA repair; Nucleus.
FT CHAIN 1..223
FT /note="Suppressor of hydroxyurea sensitivity protein 2"
FT /id="PRO_0000409745"
SQ SEQUENCE 223 AA; 26137 MW; A03C85D2992C4423 CRC64;
MSKDVIEYSK LFAKLVNTND DTKLDDTIAS FLYYMFPREL FIRAISLLES SDMFIYILDR
VHNKEGNEHT SLIDVLVDEF YKGSSNSLLE YRLIVKDTND GAPPILVDIA HWFCSCEEFC
KYFHEALEKT DEKEELHDVL INEVDDHLQF SDDRFAQLDP HSLSKQWYFK FDKICCSHLL
AFSILLRSSI NVLKFFTVNS NKVFVIAIDN IDEWLNLHIN IVE