SHUT_EHV1B
ID SHUT_EHV1B Reviewed; 497 AA.
AC P28957; Q6S6Q2;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 23-FEB-2022, entry version 81.
DE RecName: Full=Virion host shutoff protein;
DE Short=Vhs;
DE EC=3.1.27.-;
GN OrderedLocusNames=19;
OS Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=31520;
OH NCBI_TaxID=9796; Equus caballus (Horse).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=1318606; DOI=10.1016/0042-6822(92)90706-u;
RA Telford E.A.R., Watson M.S., McBride K., Davison A.J.;
RT "The DNA sequence of equine herpesvirus-1.";
RL Virology 189:304-316(1992).
CC -!- FUNCTION: Minor structural protein that acts as an endoribonuclease
CC during lytic infection. Degrades host mRNAs in the cytoplasm by cutting
CC them at preferred sites, including some in regions of translation
CC initiation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the herpesviridae VHS protein family.
CC {ECO:0000305}.
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DR EMBL; AY665713; AAT67276.1; -; Genomic_DNA.
DR PIR; B36797; WZBEB3.
DR RefSeq; YP_053064.1; NC_001491.2.
DR GeneID; 1487523; -.
DR KEGG; vg:1487523; -.
DR Proteomes; UP000001189; Genome.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0039595; P:induction by virus of catabolism of host mRNA; IEA:UniProtKB-KW.
DR GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR Pfam; PF00867; XPG_I; 1.
DR SUPFAM; SSF88723; SSF88723; 1.
PE 3: Inferred from homology;
KW Decay of host mRNAs by virus; Endonuclease;
KW Eukaryotic host gene expression shutoff by virus;
KW Host gene expression shutoff by virus; Host mRNA suppression by virus;
KW Host-virus interaction; Hydrolase; Nuclease; Reference proteome;
KW RNA-binding; Virion.
FT CHAIN 1..497
FT /note="Virion host shutoff protein"
FT /id="PRO_0000116057"
FT REGION 122..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..326
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..373
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 56543 MW; 7CB3FDD03CCD11F3 CRC64;
MGLFGLLKYA YSNRLVKHDA ITTPPGIMTP IAIDLWNVMY TLMEKFDQER NFPLDGAAVT
ARCFFSLLRL LLKRSYYPIF VSDRGIYGDG RVKQGAKAIV SQTMSSYGGS GRLSSACFTG
DEHDTEFQED PEENDVSVPP QDTCPPTEIS AGYVEPERKC EHSSTRWSAL DGAPRLSYRL
CVNLIRHLGY PYVNACNLEA DDVCANLYHT NTVAQIYTTD TDLILMGCDI ILDIMPLFPP
TLRCCDVLMD LGVTYDEFLT EFVRCHTDLH EPQTLASVQS VISSLHSPPD EDEGADMPQT
PSGHSWRCPN ERRVISWRRQ DDHDYDSSTE DSDQSDSSEE EEECPAGKGF GYRENPAVET
CKRRTRPRRS AEASGRILHL KYTSRYPPIM ESAPRALVRM APPKTRHEVL ERKFVKHVVS
MLTPERRGSL SIMRRLPITQ EPSNFSLVHD TLKNLVSEHE IARELANMFW NHIPTPTDYN
TVLVNYWDDC GHRRQWS