ID   SHUT_EHV1V              Reviewed;         497 AA.
AC   P84398; Q6S6Q2;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   23-FEB-2022, entry version 54.
DE   RecName: Full=Virion host shutoff protein;
DE            Short=Vhs;
DE            EC=3.1.27.-;
GN   OrderedLocusNames=19;
OS   Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=310273;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAS45903.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Davis-Poynter N., Nugent J., Birch-Machin I., Allen G.P.;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Minor structural protein that acts as an endoribonuclease
CC       during lytic infection. Degrades host mRNAs in the cytoplasm by cutting
CC       them at preferred sites, including some in regions of translation
CC       initiation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the herpesviridae VHS protein family.
CC       {ECO:0000305}.
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DR   EMBL; AY464052; AAS45903.1; -; Genomic_DNA.
DR   RefSeq; YP_053064.1; NC_001491.2.
DR   GeneID; 1487523; -.
DR   KEGG; vg:1487523; -.
DR   Proteomes; UP000008296; Genome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039595; P:induction by virus of catabolism of host mRNA; IEA:UniProtKB-KW.
DR   GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR006086; XPG-I_dom.
DR   Pfam; PF00867; XPG_I; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   Decay of host mRNAs by virus; Endonuclease;
KW   Eukaryotic host gene expression shutoff by virus;
KW   Host gene expression shutoff by virus; Host mRNA suppression by virus;
KW   Host-virus interaction; Hydrolase; Nuclease; RNA-binding; Virion.
FT   CHAIN           1..497
FT                   /note="Virion host shutoff protein"
FT                   /id="PRO_0000116058"
FT   REGION          122..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          280..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        311..326
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        357..373
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   497 AA;  56543 MW;  7CB3FDD03CCD11F3 CRC64;
     MGLFGLLKYA YSNRLVKHDA ITTPPGIMTP IAIDLWNVMY TLMEKFDQER NFPLDGAAVT
     ARCFFSLLRL LLKRSYYPIF VSDRGIYGDG RVKQGAKAIV SQTMSSYGGS GRLSSACFTG
     DEHDTEFQED PEENDVSVPP QDTCPPTEIS AGYVEPERKC EHSSTRWSAL DGAPRLSYRL
     CVNLIRHLGY PYVNACNLEA DDVCANLYHT NTVAQIYTTD TDLILMGCDI ILDIMPLFPP
     TLRCCDVLMD LGVTYDEFLT EFVRCHTDLH EPQTLASVQS VISSLHSPPD EDEGADMPQT
     PSGHSWRCPN ERRVISWRRQ DDHDYDSSTE DSDQSDSSEE EEECPAGKGF GYRENPAVET
     CKRRTRPRRS AEASGRILHL KYTSRYPPIM ESAPRALVRM APPKTRHEVL ERKFVKHVVS
     MLTPERRGSL SIMRRLPITQ EPSNFSLVHD TLKNLVSEHE IARELANMFW NHIPTPTDYN
     TVLVNYWDDC GHRRQWS