ID   SHUT_GAHVM              Reviewed;         441 AA.
AC   Q9E6N0;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   29-SEP-2021, entry version 72.
DE   RecName: Full=Virion host shutoff protein;
DE            Short=Vhs;
DE            EC=3.1.27.-;
GN   Name=MDV054;
OS   Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's
OS   disease herpesvirus type 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10389;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10933706; DOI=10.1128/jvi.74.17.7980-7988.2000;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.;
RT   "The genome of a very virulent Marek's disease virus.";
RL   J. Virol. 74:7980-7988(2000).
CC   -!- FUNCTION: Minor structural protein that acts as an endoribonuclease
CC       during lytic infection. Degrades host mRNAs in the cytoplasm by cutting
CC       them at preferred sites, including some in regions of translation
CC       initiation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the herpesviridae VHS protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF243438; AAG14234.1; -; Genomic_DNA.
DR   RefSeq; YP_001033970.1; NC_002229.3.
DR   PRIDE; Q9E6N0; -.
DR   GeneID; 4811515; -.
DR   KEGG; vg:4811515; -.
DR   Proteomes; UP000008072; Genome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039595; P:induction by virus of catabolism of host mRNA; IEA:UniProtKB-KW.
DR   GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR006086; XPG-I_dom.
DR   Pfam; PF00867; XPG_I; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   Decay of host mRNAs by virus; Endonuclease;
KW   Eukaryotic host gene expression shutoff by virus;
KW   Host gene expression shutoff by virus; Host mRNA suppression by virus;
KW   Host-virus interaction; Hydrolase; Nuclease; Reference proteome;
KW   RNA-binding; Virion.
FT   CHAIN           1..441
FT                   /note="Virion host shutoff protein"
FT                   /id="PRO_0000406518"
SQ   SEQUENCE   441 AA;  50398 MW;  BC3489C41034D49A CRC64;
     MGVYGCMNFA YANGLVRSHI SGFISGGDMT PIAVDLWNVM YGLLEKLYPG KIDGVDDSII
     TLRCLYCLLR LLHQRSYYPV FVADRGFYGN GKTLYGAKAI AATCIATRGG SGRLHARLFD
     ECGSTDVGEA RCKRKHPGKK VCRWSERFET PKILYQLCMS IIRYMGYPYV DAGTMEADDI
     CANLFHTKTV AYVLSSDTDL ILMGCDIIID LTRIFPPTIY CRDVLAALQM DYFTFLLNFV
     RCHTDLHREP TLKSMQEIIN LSSAKRCLHD TDCATDDDVP RCIRPLYEEQ DRRTGENSYH
     SEGFDLHIRK DQSKTSCWDN DVSNYTDTNL IRGVQKALKS LRPPRTRCEI LEYKFIKHVI
     ATIIPERRTS RVSILKRFPI MQEGRDETAV EDLIFCNIFD VDEASTIVSQ FIKRIPEVRP
     LNHILLKYWG NDALKTTRSN D