ID   SHUT_PSHV1              Reviewed;         440 AA.
AC   Q6UDJ0;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   29-SEP-2021, entry version 60.
DE   RecName: Full=Virion host shutoff protein;
DE            Short=Vhs;
DE            EC=3.1.27.-;
GN   Name=UL41;
OS   Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1)
OS   (Pacheco's disease virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Iltovirus.
OX   NCBI_TaxID=670426;
OH   NCBI_TaxID=152276; Amazona oratrix (yellow-headed parrot).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16873243; DOI=10.1128/jvi.00134-06;
RA   Thureen D.R., Keeler C.L. Jr.;
RT   "Psittacid herpesvirus 1 and infectious laryngotracheitis virus:
RT   Comparative genome sequence analysis of two avian alphaherpesviruses.";
RL   J. Virol. 80:7863-7872(2006).
CC   -!- FUNCTION: Minor structural protein that acts as an endoribonuclease
CC       during lytic infection. Degrades host mRNAs in the cytoplasm by cutting
CC       them at preferred sites, including some in regions of translation
CC       initiation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the herpesviridae VHS protein family.
CC       {ECO:0000305}.
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DR   EMBL; AY372243; AAQ73720.1; -; Genomic_DNA.
DR   RefSeq; NP_944414.1; NC_005264.1.
DR   GeneID; 2656984; -.
DR   KEGG; vg:2656984; -.
DR   Proteomes; UP000006840; Genome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039595; P:induction by virus of catabolism of host mRNA; IEA:UniProtKB-KW.
DR   GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   Decay of host mRNAs by virus; Endonuclease;
KW   Eukaryotic host gene expression shutoff by virus;
KW   Host gene expression shutoff by virus; Host mRNA suppression by virus;
KW   Host-virus interaction; Hydrolase; Nuclease; Reference proteome;
KW   RNA-binding; Virion.
FT   CHAIN           1..440
FT                   /note="Virion host shutoff protein"
FT                   /id="PRO_0000406830"
FT   REGION          98..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          265..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..300
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   440 AA;  49502 MW;  E41F08C1B2389924 CRC64;
     MGILGMRRFI REHELSVHLS IQMERGLYIP IAVDTWNVLT PIMRRLDPGN MMDPVERTLR
     GIMQVFSLLN KKSCFPIFVL DGGRKRAFKG PVKHDYHNID HRAPTDGDDL EASANENQPH
     SLAGNAPRLA SGARGAHQSS RRKTALRATP HYKLCWDLIT ASGFPTVYVK GMEADYGCAN
     LFHTKTVMYV WSSDSDMVFM GCDVITDLTP AFPVAVFSKH VLEYLNMTQR EFANTFVDCH
     TNLHSPETIY SFAAKLLEHR CGSAIDEPPA ASEESSASDQ QSADEDEHGA WSRYTRRPPR
     RADAAAWGAG PGGNGQLKGV SVLCGFPSDA RPFDCAPARR RRLPQRREEP AARLKKNREF
     LAYMNSFIGC KVINNRHTLI KRVPIRQETF DPVEIYRILH EYAPTMANKW CAEMLVKCKL
     KPVPPLRDVA YGKATQINLC