ID   SHUT_SUHVK              Reviewed;         365 AA.
AC   P36314;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   23-FEB-2022, entry version 63.
DE   RecName: Full=Virion host shutoff protein;
DE            Short=Vhs;
DE            EC=3.1.27.-;
GN   Name=VHS;
OS   Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain
OS   Kaplan)).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=33703;
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8384744; DOI=10.1006/viro.1993.1221;
RA   Berthomme H., Jacquemont B., Epstein A.;
RT   "The pseudorabies virus host-shutoff homolog gene: nucleotide sequence and
RT   comparison with alphaherpesvirus protein counterparts.";
RL   Virology 193:1028-1032(1993).
CC   -!- FUNCTION: Minor structural protein that acts as an endoribonuclease
CC       during lytic infection. Degrades host mRNAs in the cytoplasm by cutting
CC       them at preferred sites, including some in regions of translation
CC       initiation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the herpesviridae VHS protein family.
CC       {ECO:0000305}.
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DR   EMBL; S57917; AAB25948.2; -; Genomic_DNA.
DR   PIR; A46117; A46117.
DR   RefSeq; YP_068344.1; NC_006151.1.
DR   SMR; P36314; -.
DR   GeneID; 2952522; -.
DR   KEGG; vg:2952522; -.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039595; P:induction by virus of catabolism of host mRNA; IEA:UniProtKB-KW.
DR   GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   Decay of host mRNAs by virus; Endonuclease;
KW   Eukaryotic host gene expression shutoff by virus;
KW   Host gene expression shutoff by virus; Host mRNA suppression by virus;
KW   Host-virus interaction; Hydrolase; Nuclease; RNA-binding; Virion.
FT   CHAIN           1..365
FT                   /note="Virion host shutoff protein"
FT                   /id="PRO_0000116060"
SQ   SEQUENCE   365 AA;  40910 MW;  9F73212F5B8F1EEA CRC64;
     MGLFGLLKYA HRHRLVRSEA ISTPPGVLTP IAIDLWNVMY TLMEKHYQET TEDNATTTAR
     CLLRLLRMLH KRTYFPIFVS DRGIFGNGRI ARGAKAIMAA AVRADGDGAA DAPPRPRWST
     MLHAPRIVHR LCVNLIRHMG YAYVDVSDME ADDVCANLYH TNTVAQVHTT DTDMILTGCD
     MILDIAPVFP LVLRCRDVLA SLGVDYSEFL AAFVRCHTDL HRAPDVDSVQ QVAESLEGRE
     VAPEDVKLKY ASRCPDIMRD AGKALALLPA AGDARSPRAE REFIQHVVAM LTPARHGHLS
     VLRRVPIVQE PSDVNKVFGS LLRHVKNETR AKELAGLFWK HIPPPPNYQA VLMAYWDDCN
     AHRRK