ID   SHUT_VZVD               Reviewed;         455 AA.
AC   P09275;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   23-FEB-2022, entry version 77.
DE   RecName: Full=Virion host shutoff protein;
DE            Short=Vhs;
DE            EC=3.1.27.-;
GN   Name=17;
OS   Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10338;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=3018124; DOI=10.1099/0022-1317-67-9-1759;
RA   Davison A.J., Scott J.E.;
RT   "The complete DNA sequence of varicella-zoster virus.";
RL   J. Gen. Virol. 67:1759-1816(1986).
CC   -!- FUNCTION: Minor structural protein that acts as an endoribonuclease
CC       during lytic infection. Degrades host mRNAs in the cytoplasm by cutting
CC       them at preferred sites, including some in regions of translation
CC       initiation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the herpesviridae VHS protein family.
CC       {ECO:0000305}.
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DR   EMBL; X04370; CAA27900.1; -; Genomic_DNA.
DR   PIR; H27342; WZBE17.
DR   PRIDE; P09275; -.
DR   Proteomes; UP000002602; Genome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039595; P:induction by virus of catabolism of host mRNA; IEA:UniProtKB-KW.
DR   GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   Decay of host mRNAs by virus; Endonuclease;
KW   Eukaryotic host gene expression shutoff by virus;
KW   Host gene expression shutoff by virus; Host mRNA suppression by virus;
KW   Host-virus interaction; Hydrolase; Nuclease; Reference proteome;
KW   RNA-binding; Virion.
FT   CHAIN           1..455
FT                   /note="Virion host shutoff protein"
FT                   /id="PRO_0000116059"
SQ   SEQUENCE   455 AA;  51368 MW;  9D9EE755903DC4C7 CRC64;
     MGLFGLTRFI HEHKLVKPSI ISTPPGVLTP VAVDVWNVMY TLLERLYPVG KRENLHGPSV
     TIHCLGVLLR LLTQRSYYPI FVLERCTDGP LSRGAKAIMS RAMNHDERGT SDLTRVLLSS
     NTSCSIKYNK TSETYDSVFR NSSTSCIPSE ENKSQDMFLD GCPRQTDKTI CLRDQNVCSL
     TSTMPSRGHP NHRLYHKLCA SLIRWMGYAY VEAVDIEADE ACANLFHTRT VALVYTTDTD
     LLFMGCDILL DAIPMFAPVV RCRDLLQYLG ITYPEFLVAF VRCQTDLHTS DNLKSVQQVI
     QDTGLKVPHQ MDTSTRSPTY DSWRHGEVFK SLTVATSGKT ENGVSVSKYA SNRSEVTVDA
     SWALNLLPPS SSPLDNLERA FVEHIIAVVT PLTRGRLKLM KRVNIMQNTA DPYMVINTLY
     HNLKGEKMAR QYARIFKQFI PTPLPLNTVL TKYWN