SH_MUMP2
ID SH_MUMP2 Reviewed; 57 AA.
AC P69187; P28084;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 23-FEB-2022, entry version 47.
DE RecName: Full=Small hydrophobic protein;
GN Name=SH;
OS Mumps virus (strain Edingburgh 2) (MuV).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Paramyxoviridae; Rubulavirinae;
OC Orthorubulavirus; Mumps orthorubulavirus.
OX NCBI_TaxID=11162;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=8435047; DOI=10.1007/bf01309447;
RA Yeo R.P., Afzal M.A., Forsey T., Rima B.K.;
RT "Identification of a new mumps virus lineage by nucleotide sequence
RT analysis of the SH gene of ten different strains.";
RL Arch. Virol. 128:371-377(1993).
CC -!- FUNCTION: Plays a role in the inhibition of the host NF-kappa-B
CC pathway. This inhibition occurs at the receptor level, by preventing
CC the signaling of TNFR1 as well as IL-1R and TLR3.
CC {ECO:0000250|UniProtKB:P22112}.
CC -!- SUBUNIT: Interacts with host TNFRSF1A, RIPK1 AND IRAK1; these
CC interactions interfere with host NF-kappa-B activation at the level of
CC receptor complexes (By similarity). Interacts with host protein UBQLN4
CC (By similarity). {ECO:0000250|UniProtKB:P22110,
CC ECO:0000250|UniProtKB:P22112}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250|UniProtKB:P22112};
CC Single-pass membrane protein {ECO:0000250|UniProtKB:P22112}. Host cell
CC membrane {ECO:0000250|UniProtKB:P22112}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:P22112}.
CC -!- SIMILARITY: Belongs to the rubulavirus small hydrophobic protein
CC family. {ECO:0000305}.
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DR EMBL; X63711; CAA45244.1; -; Genomic_RNA.
DR PIR; S19868; SHNZE2.
DR SMR; P69187; -.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IEA:UniProtKB-KW.
DR InterPro; IPR001477; SH.
DR Pfam; PF01445; SH; 1.
DR PIRSF; PIRSF003923; SH; 1.
PE 3: Inferred from homology;
KW Host cell membrane; Host membrane; Host-virus interaction;
KW Inhibition of host NF-kappa-B by virus; Membrane; Transmembrane;
KW Transmembrane helix; Virion.
FT CHAIN 1..57
FT /note="Small hydrophobic protein"
FT /id="PRO_0000142874"
FT TOPO_DOM 1..8
FT /note="Virion surface"
FT /evidence="ECO:0000255"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..57
FT /note="Intravirion"
FT /evidence="ECO:0000255"
SQ SEQUENCE 57 AA; 6894 MW; 49121303FE0DED94 CRC64;
MPLIQPPLYL TFLLLMLLYR IITLYVWSLS TITYKTSVRH ASLYQRSFFR WSVDHSL