ID   SH_MUMPM                Reviewed;          57 AA.
AC   P22112; Q783V8;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   23-FEB-2022, entry version 68.
DE   RecName: Full=Small hydrophobic protein;
GN   Name=SH;
OS   Mumps virus (strain Miyahara vaccine) (MuV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Rubulavirinae;
OC   Orthorubulavirus; Mumps orthorubulavirus.
OX   NCBI_TaxID=11171;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1585659; DOI=10.1016/0042-6822(92)90555-4;
RA   Okazaki K., Tanabayashi K., Takeuchi K., Hishiyama M., Okazaki K.,
RA   Yamada A.;
RT   "Molecular cloning and sequence analysis of the mumps virus gene encoding
RT   the L protein and the trailer sequence.";
RL   Virology 188:926-930(1992).
RN   [2]
RP   FUNCTION, AND INTERACTION WITH HOST TNFRSF1A; RIPK1 AND IRAK1.
RX   PubMed=28659487; DOI=10.1128/jvi.01037-17;
RA   Franz S., Rennert P., Woznik M., Gruetzke J., Luedde A., Arriero Pais E.M.,
RA   Finsterbusch T., Geyer H., Mankertz A., Friedrich N.;
RT   "Mumps virus SH protein inhibits NF-kappaB activation by interacting with
RT   tumor necrosis factor receptor 1, interleukin-1 receptor 1, and Toll-like
RT   receptor 3 complexes.";
RL   J. Virol. 91:0-0(2017).
CC   -!- FUNCTION: Plays a role in the inhibition of the host NF-kappa-B
CC       pathway. This inhibition occurs at the receptor level, by preventing
CC       the signaling of TNFR1 as well as IL-1R and TLR3.
CC       {ECO:0000269|PubMed:28659487}.
CC   -!- SUBUNIT: Interacts with host TNFRSF1A, RIPK1 AND IRAK1; these
CC       interactions interfere with host NF-kappa-B activation at the level of
CC       receptor complexes (PubMed:28659487). Interacts with host protein
CC       UBQLN4 (By similarity). {ECO:0000250|UniProtKB:P22110,
CC       ECO:0000269|PubMed:28659487}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}. Host cell membrane {ECO:0000305};
CC       Single-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the rubulavirus small hydrophobic protein
CC       family. {ECO:0000305}.
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DR   EMBL; D90234; BAA14282.1; -; Genomic_RNA.
DR   EMBL; AB040874; BAA94389.1; -; Genomic_RNA.
DR   PIR; JU0304; SHNZMS.
DR   SMR; P22112; -.
DR   Proteomes; UP000002331; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IDA:UniProtKB.
DR   InterPro; IPR001477; SH.
DR   Pfam; PF01445; SH; 1.
DR   PIRSF; PIRSF003923; SH; 1.
PE   1: Evidence at protein level;
KW   Host cell membrane; Host membrane; Host-virus interaction;
KW   Inhibition of host NF-kappa-B by virus; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Virion.
FT   CHAIN           1..57
FT                   /note="Small hydrophobic protein"
FT                   /id="PRO_0000142881"
FT   TOPO_DOM        1..8
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..57
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   57 AA;  6621 MW;  BC794E57A4A0F9E6 CRC64;
     MPAIQPPLYP TFLLLILLSL IITLYVWIIS TITYKTAVRH AALHQRSFSR WSLDHSL