ID   SH_MUMPU                Reviewed;          57 AA.
AC   P20716;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   23-FEB-2022, entry version 65.
DE   RecName: Full=Small hydrophobic protein;
GN   Name=SH;
OS   Mumps virus (strain Urabe vaccine AM9) (MuV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Rubulavirinae;
OC   Orthorubulavirus; Mumps orthorubulavirus.
OX   NCBI_TaxID=11175;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1993881; DOI=10.1099/0022-1317-72-2-435;
RA   Turner P.C., Forsey T., Minor P.D.;
RT   "Comparison of the nucleotide sequence of the SH gene and flanking regions
RT   of mumps vaccine virus (Urabe strain) grown on different substrates and
RT   isolated from vaccinees.";
RL   J. Gen. Virol. 72:435-437(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Takeuchi K.;
RL   Submitted (NOV-1990) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the inhibition of the host NF-kappa-B
CC       pathway. This inhibition occurs at the receptor level, by preventing
CC       the signaling of TNFR1 as well as IL-1R and TLR3.
CC       {ECO:0000250|UniProtKB:P22112}.
CC   -!- SUBUNIT: Interacts with host TNFRSF1A, RIPK1 AND IRAK1; these
CC       interactions interfere with host NF-kappa-B activation at the level of
CC       receptor complexes (By similarity). Interacts with host protein UBQLN4
CC       (By similarity). {ECO:0000250|UniProtKB:P22110,
CC       ECO:0000250|UniProtKB:P22112}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250|UniProtKB:P22112};
CC       Single-pass membrane protein {ECO:0000250|UniProtKB:P22112}. Host cell
CC       membrane {ECO:0000250|UniProtKB:P22112}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:P22112}.
CC   -!- SIMILARITY: Belongs to the rubulavirus small hydrophobic protein
CC       family. {ECO:0000305}.
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DR   EMBL; X52816; CAA37000.1; -; Genomic_RNA.
DR   EMBL; D90236; BAA14284.1; -; Genomic_RNA.
DR   PIR; A38479; SHNZMU.
DR   SMR; P20716; -.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IEA:UniProtKB-KW.
DR   InterPro; IPR001477; SH.
DR   Pfam; PF01445; SH; 1.
DR   PIRSF; PIRSF003923; SH; 1.
PE   3: Inferred from homology;
KW   Host cell membrane; Host membrane; Host-virus interaction;
KW   Inhibition of host NF-kappa-B by virus; Membrane; Transmembrane;
KW   Transmembrane helix; Virion.
FT   CHAIN           1..57
FT                   /note="Small hydrophobic protein"
FT                   /id="PRO_0000142885"
FT   TOPO_DOM        1..8
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..57
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   57 AA;  6755 MW;  AC784E440AD92CE6 CRC64;
     MPAIQPPLYP TFLLLILLSL IVTLYVWIIS TITYKTVVRH AALYQRSFFR WSFDHSL