ID   SH_PIV5                 Reviewed;          44 AA.
AC   P07577;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Small hydrophobic protein;
GN   Name=SH;
OS   Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Rubulavirinae;
OC   Orthorubulavirus; Mammalian orthorubulavirus 5.
OX   NCBI_TaxID=11208;
OH   NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=4020965; DOI=10.1128/jvi.55.3.744-751.1985;
RA   Hiebert S.W., Paterson R.G., Lamb R.A.;
RT   "Identification and predicted sequence of a previously unrecognized small
RT   hydrophobic protein, SH, of the paramyxovirus simian virus 5.";
RL   J. Virol. 55:744-751(1985).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=2836617; DOI=10.1128/jvi.62.7.2347-2357.1988;
RA   Hiebert S.W., Richardson C.D., Lamb R.A.;
RT   "Cell surface expression and orientation in membranes of the 44-amino-acid
RT   SH protein of simian virus 5.";
RL   J. Virol. 62:2347-2357(1988).
RN   [3]
RP   FUNCTION.
RX   PubMed=11287556; DOI=10.1128/jvi.75.9.4068-4079.2001;
RA   He B., Lin G.Y., Durbin J.E., Durbin R.K., Lamb R.A.;
RT   "The SH integral membrane protein of the paramyxovirus simian virus 5 is
RT   required to block apoptosis in MDBK cells.";
RL   J. Virol. 75:4068-4079(2001).
CC   -!- FUNCTION: Inhibits TNF-alpha signaling and seems to block apoptosis in
CC       host infected cells. {ECO:0000269|PubMed:11287556}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type
CC       II membrane protein {ECO:0000305}. Host cell membrane {ECO:0000305};
CC       Single-pass type II membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the rubulavirus small hydrophobic protein
CC       family. {ECO:0000305}.
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DR   EMBL; M11785; AAA47883.1; -; Genomic_RNA.
DR   EMBL; AF052755; AAC95516.1; -; Genomic_RNA.
DR   PIR; A25482; SHNZS5.
DR   SMR; P07577; -.
DR   TCDB; 1.A.103.1.1; the simian virus 5 (parainfluenza virus 5) sh (sv5-sh) family.
DR   Proteomes; UP000007232; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Host cell membrane; Host membrane; Membrane; Signal-anchor; Transmembrane;
KW   Transmembrane helix; Virion.
FT   CHAIN           1..44
FT                   /note="Small hydrophobic protein"
FT                   /id="PRO_0000142886"
FT   TOPO_DOM        1..16
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        17..37
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        38..44
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   44 AA;  5108 MW;  F65A518D915886AD CRC64;
     MLPDPEDPES KKATRRAGNL IICFLFIFFL FVTFIVPTLR HLLS