BH052_ARATH
ID BH052_ARATH Reviewed; 264 AA.
AC Q9SA82; Q8S3E6;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Transcription factor bHLH52;
DE AltName: Full=Basic helix-loop-helix protein 52;
DE Short=AtbHLH52;
DE Short=bHLH 52;
DE AltName: Full=Transcription factor EN 124;
DE AltName: Full=bHLH transcription factor bHLH052;
GN Name=BHLH52; Synonyms=EN124; OrderedLocusNames=At1g30670; ORFNames=T5I8.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed constitutively in roots, leaves, stems,
CC and flowers. {ECO:0000269|PubMed:12679534}.
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DR EMBL; AF488587; AAM10944.1; -; mRNA.
DR EMBL; AC007060; AAD25754.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31258.1; -; Genomic_DNA.
DR PIR; B86432; B86432.
DR RefSeq; NP_174355.1; NM_102804.2.
DR AlphaFoldDB; Q9SA82; -.
DR SMR; Q9SA82; -.
DR PaxDb; Q9SA82; -.
DR PRIDE; Q9SA82; -.
DR EnsemblPlants; AT1G30670.1; AT1G30670.1; AT1G30670.
DR GeneID; 839947; -.
DR Gramene; AT1G30670.1; AT1G30670.1; AT1G30670.
DR KEGG; ath:AT1G30670; -.
DR Araport; AT1G30670; -.
DR TAIR; locus:2204569; AT1G30670.
DR eggNOG; ENOG502S03F; Eukaryota.
DR HOGENOM; CLU_083453_0_0_1; -.
DR InParanoid; Q9SA82; -.
DR OMA; HNTAEMF; -.
DR OrthoDB; 1490131at2759; -.
DR PhylomeDB; Q9SA82; -.
DR PRO; PR:Q9SA82; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SA82; baseline.
DR GO; GO:0005634; C:nucleus; HDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR CDD; cd11393; bHLH_AtbHLH_like; 1.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR045239; bHLH95_bHLH.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..264
FT /note="Transcription factor bHLH52"
FT /id="PRO_0000358749"
FT DOMAIN 134..183
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT CONFLICT 51..53
FT /note="LPS -> PPG (in Ref. 1; AAM10944)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 264 AA; 30444 MW; 06CF2095486E3EE4 CRC64;
MIIPETDSFF FQEQPQHQPL YPDEALSPSL FGFDHYDHFY ESFLPSQEIF LPSPKTRVFN
ESQELDSFHT PKHQKLIDSS FHFNSHDPFS PSPESNYLLD SYITEASNIS KFQAPDFSST
FKVGWTEQGD TKKRELSAQS IAARKRRRRI TEKTQELGKL IPGSQKHNTA EMFNAAAKYV
KFLQAQIEIL QLKQTKMQTL DSSKVGREMQ FLLGSQEIQE KLSTEEVCVV PREMVQVLKA
EECILTNPKI SRDINKLLST NLMN
