SI1L2_RAT
ID SI1L2_RAT Reviewed; 1722 AA.
AC Q5JCS6;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Signal-induced proliferation-associated 1-like protein 2;
DE Short=SIPA1-like protein 2;
DE AltName: Full=Serine-rich synapse-associated protein;
GN Name=Sipa1l2; Synonyms=Sersap2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar;
RA Boeckers T.M., Wendholt D., Bockmann J.;
RT "Cloning of a novel family of serine rich synapse associated proteins:
RT SERSAPs.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149; SER-1245; SER-1461;
RP SER-1478; SER-1488 AND SER-1549, AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
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DR EMBL; AY043227; AAL02130.1; -; mRNA.
DR RefSeq; NP_001009704.1; NM_001009704.1.
DR AlphaFoldDB; Q5JCS6; -.
DR SMR; Q5JCS6; -.
DR BioGRID; 262684; 1.
DR STRING; 10116.ENSRNOP00000026843; -.
DR iPTMnet; Q5JCS6; -.
DR PhosphoSitePlus; Q5JCS6; -.
DR PaxDb; Q5JCS6; -.
DR PRIDE; Q5JCS6; -.
DR GeneID; 361442; -.
DR KEGG; rno:361442; -.
DR UCSC; RGD:1306269; rat.
DR CTD; 57568; -.
DR RGD; 1306269; Sipa1l2.
DR eggNOG; KOG3686; Eukaryota.
DR InParanoid; Q5JCS6; -.
DR PhylomeDB; Q5JCS6; -.
DR PRO; PR:Q5JCS6; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.40.50.11210; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR031203; SIPA1L2.
DR InterPro; IPR021818; SIPA1L_C.
DR PANTHER; PTHR15711:SF7; PTHR15711:SF7; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF11881; SPAR_C; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF111347; SSF111347; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 1: Evidence at protein level;
KW Coiled coil; GTPase activation; Phosphoprotein; Reference proteome.
FT CHAIN 1..1722
FT /note="Signal-induced proliferation-associated 1-like
FT protein 2"
FT /id="PRO_0000056751"
FT DOMAIN 596..813
FT /note="Rap-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00165"
FT DOMAIN 951..1027
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 45..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1068..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1197..1246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1328..1361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1652..1712
FT /evidence="ECO:0000255"
FT COMPBIAS 385..402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1092..1106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1114..1133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1215..1242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 149
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 380
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE4"
FT MOD_RES 384
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE4"
FT MOD_RES 1030
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9P2F8"
FT MOD_RES 1245
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 1461
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 1472
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE4"
FT MOD_RES 1478
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 1488
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 1549
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 1552
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9P2F8"
FT MOD_RES 1591
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE4"
SQ SEQUENCE 1722 AA; 189653 MW; 213DCA7DF7694167 CRC64;
MSDPRPSQAE KHKLGRAASK FKDPSRAMQS DDYFARKFKA INGSMGPATL NTSSLSEGGG
GGGGPANGTP AVPKMGVRAR VSEWPPKKDC SKDLACKTLW ESRSQSSYES ATSIIQNGQN
DQVDRQQEEQ LDLDFVEAKY TIGDIFVHSP QRGLHPIRQR SNSDITISDI DTEDVLDQHA
VNPNTGAALH REYGSTSSID RQGLSGENVF AMLRGYRIES YDPKVTSSFG FPDFFPCDTA
ISPSLHAAAQ ISRGEFVRIS GLDYMDGGLL MGRDRDKPFK RRLKSESVET SLFRKLRTVK
SEHETFKFTS DLEEGRLDRG IRPWSCQRCF AHYDVQSILF NINEAMATRA SVGKRKNITT
GASAASQTPV PVGPAGGCES PLGSKEDLNA KENPDADEGD GKSNDLVLSC PYFRNETGGE
GDRRIALSRA NSASFSSGES CSFESSLSSH CTNAGVSVLE VPRENQPIHR EKVKRYIIEH
VDLGAYYYRK FFYGKEHQNY FGIDENLGPV AVSIRREKVE DPREKEGSQF NYRVAFRTSE
LTTLRGAILE DAVPSTARHG TARGLPLKEV LEYVIPELSI PCLRQAANSP KVPEQLLKLD
EQGLSFQHKI GILYCKAGQS TEEEMYNNET AGPAFEEFLD LLGQRVRLKG FSKYRAQLDN
KTDSTGTHSL YTTYKDFELM FHVSTLLPYM PNNRQQLLRK RHIGNDIVTI VFQEPGALPF
TPKNIRSHFQ HVFVIVKVHN PCTENVCYSV GVFRSKDVPP FVPPIPKGVT FPRTGVFRDF
LLAKGINAEN AAHKSEKFRA MATRTRHEYL KDLAENFVTT TTVDTSAKFS FITLGAKKKE
RVKPRTDAHL FSIGAIMWHV VARYFGQSAD IECLLGISNE FIMLIEKESK NVAFNCSCRD
VIGWTSGLVS IKIFYERGEC ILLSSVDNSS EDIREIVQRL VIVTRGCETV EMTLRRNGLG
QLGFHVNFEG IVADVEPFGF AWKAGLRQGS RLVEICKVAV ATLTHEQMID LLRTSVTVKV
VIIQPHEDGS PRRGCSELCR IPMVEYKLDS EGTPCEYKTP FRRNTTWHRV PTPALQPVSR
ASPVPGTPDR LQCQPLLQQA QAAIPRSTSF DRKLPDGTRS SPSNQSSSSD PGPGGSGPWR
PQVGYDGCPS PLLLEPQGPG SVECDGSGDH EDLMEVGRLP ETKWHGPPSK VLSSYKERAL
QKDGSCKDSP NKLSHIGDKS CSSHSSSNTL SSNTSSNSDD KHFGSGDLMD PELLGLTYIK
GASTDSGIDT TPCMPATILG PMHLTGSRSL IHSRAEQWAD AADVSGADED PAKMYTLHGY
ASAISSSAAD GSMGDLSEVS SHSSGSHRSG SPSTHCSKST GSLDSSKVYI VTHSGGQQVP
GAVAKPYHRQ GAANKYVIGW KKSEGSPPPE EPEVTECPRI YGEMDIMSTA SQHPAVVGDS
VPEAQHVLSK DDFLKLMLPD SPLVEEGRRK FSFYGNLSPR RSLYRTLSDE SVCSNRRGSS
FASSRSSILD QALPNDILFS TTPPYHSTLP PRTHPAPSMG SLRNEFWFSD GSLSDKSKCA
DPGLMPLPDT AAGLDWSHLV DAARAFEGLD SDEELGLLCH HASYLDQRVA SFCTLTDLQH
GQELEGAPEL SLCVDPTSGK EFMDTPGERS PSTLTGKVNQ LELILRQLQT DLRKEKQDKA
VLQAEVQHLR QDNMRLQEES QTATAQLRTF TEWFFSTIDK KV
