BH053_ARATH
ID BH053_ARATH Reviewed; 291 AA.
AC Q84RD0; O64746;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Transcription factor bHLH53;
DE AltName: Full=Basic helix-loop-helix protein 53;
DE Short=AtbHLH53;
DE Short=bHLH 53;
DE AltName: Full=Transcription factor EN 123;
DE AltName: Full=bHLH transcription factor bHLH053;
GN Name=BHLH53; Synonyms=EN123; OrderedLocusNames=At2g34820; ORFNames=F19I3.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=12481096; DOI=10.1104/pp.010207;
RA Xiao Y.-L., Malik M., Whitelaw C.A., Town C.D.;
RT "Cloning and sequencing of cDNAs for hypothetical genes from chromosome 2
RT of Arabidopsis.";
RL Plant Physiol. 130:2118-2128(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 26-291, TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [5]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed constitutively in roots, leaves, stems,
CC and flowers. {ECO:0000269|PubMed:12679534}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC12822.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC004238; AAC12822.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC09025.1; -; Genomic_DNA.
DR EMBL; AY234412; AAO92056.1; -; mRNA.
DR EMBL; AF488588; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; T00464; T00464.
DR RefSeq; NP_181028.2; NM_129035.4.
DR AlphaFoldDB; Q84RD0; -.
DR SMR; Q84RD0; -.
DR STRING; 3702.AT2G34820.1; -.
DR PaxDb; Q84RD0; -.
DR PRIDE; Q84RD0; -.
DR EnsemblPlants; AT2G34820.1; AT2G34820.1; AT2G34820.
DR GeneID; 818047; -.
DR Gramene; AT2G34820.1; AT2G34820.1; AT2G34820.
DR KEGG; ath:AT2G34820; -.
DR Araport; AT2G34820; -.
DR TAIR; locus:2044762; AT2G34820.
DR eggNOG; ENOG502S03F; Eukaryota.
DR HOGENOM; CLU_083453_0_0_1; -.
DR InParanoid; Q84RD0; -.
DR OMA; FDESHNM; -.
DR OrthoDB; 1490131at2759; -.
DR PhylomeDB; Q84RD0; -.
DR PRO; PR:Q84RD0; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q84RD0; baseline and differential.
DR Genevisible; Q84RD0; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR CDD; cd11393; bHLH_AtbHLH_like; 1.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR045239; bHLH95_bHLH.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..291
FT /note="Transcription factor bHLH53"
FT /id="PRO_0000358750"
FT DOMAIN 163..212
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
SQ SEQUENCE 291 AA; 33570 MW; 2C70328D14B7DE6A CRC64;
MSMDCLSYFF NYDPPVQLQD CFIPEMDMII PETDSFFFQS QPQLEFHQPL FQEEAPSQTH
FDPFCDQFLS PQEIFLPNPK NEIFNETHDL DFFLPTPKRQ RLVNSSYNCN TQNHFQSRNP
NFFDPFGDTD FVPESCTFQE FRVPDFSLAF KVGRGDQDDS KKPTLSSQSI AARGRRRRIA
EKTHELGKLI PGGNKLNTAE MFQAAAKYVK FLQSQVGILQ LMQTTKKGSS NVQMETQYLL
ESQAIQEKLS TEEVCLVPCE MVQDLTTEET ICRTPNISRE INKLLSKHLA N
