ID   SIA1_KLULA              Reviewed;         578 AA.
AC   Q6CPQ2;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Protein SIA1;
DE   Flags: Precursor;
GN   Name=SIA1; OrderedLocusNames=KLLA0E03080g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: May be involved in the activation of the plasma membrane
CC       proton-ATPase by glucose. {ECO:0000250}.
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DR   EMBL; CR382125; CAG99174.1; -; Genomic_DNA.
DR   RefSeq; XP_454087.1; XM_454087.1.
DR   AlphaFoldDB; Q6CPQ2; -.
DR   STRING; 28985.XP_454087.1; -.
DR   EnsemblFungi; CAG99174; CAG99174; KLLA0_E03147g.
DR   GeneID; 2893910; -.
DR   KEGG; kla:KLLA0_E03147g; -.
DR   eggNOG; KOG1432; Eukaryota.
DR   HOGENOM; CLU_033929_0_0_1; -.
DR   InParanoid; Q6CPQ2; -.
DR   OMA; HEHGNDC; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF00149; Metallophos; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..578
FT                   /note="Protein SIA1"
FT                   /id="PRO_0000042718"
SQ   SEQUENCE   578 AA;  67593 MW;  F9E4CE8BCD5C9174 CRC64;
     MFRNRRILLY ARRFFLVWIC FLFITSWSLI QRHLKNWLVQ APDLKLSGSL QDTGIKVRDV
     RISKCYSWFS NCDAIWDYSL QDDLVTWYRI DMGKMQDTSI GQGFGWTSYV YWQPLYPNER
     GSAVVDLALS RNGLPLGLAN ERYNKIKNND IDGYHVHSNT DNEFYVKDDS SNRFNPDMKW
     SAKFGNHLED WFWRGDGIWC KYGRRSNGIK EIKAFIGEDF IESRPMWKEM VHCLHREGYS
     KPISISFQKS RLDDFTYGKE KDLSQISEPS LVMKRADFKI LQISDLHFGR HIVSDSRKEK
     PDSIFRYDWP NVQFIHSVIR NERPDLAVIT GHIFKDFNKN LDYESQILKM VSPIISNGIP
     FLFTWGEPQV TTEFKVNILN FIKSLPFCLN KFDLKNSTYL MLPLLLPAKT PGSQKQIGTI
     FAFDSNVTES YNFLDKFPRS PQSVYNLAFQ HLPLHEYRPQ GSFALIGNYE QKGSLDYIPH
     TKAFRNLLGE KDIKAISCGH EHGNDCCVLS DGKQQNLKNN MWLCYGGVTG YDQAYESKVR
     IFKIDTEKND ITSWKRSIKD TSKVSDYQYI WSRTLNTQ