SIA1_YEAST
ID SIA1_YEAST Reviewed; 622 AA.
AC Q12212; D6W2J4;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Protein SIA1;
DE Flags: Precursor;
GN Name=SIA1; OrderedLocusNames=YOR137C; ORFNames=YOR3329C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9200815;
RX DOI=10.1002/(sici)1097-0061(19970615)13:7<655::aid-yea120>3.0.co;2-i;
RA Voss H., Benes V., Andrade M.A., Valencia A., Rechmann S., Teodoru C.,
RA Schwager C., Paces V., Sander C., Ansorge W.;
RT "DNA sequencing and analysis of 130 kb from yeast chromosome XV.";
RL Yeast 13:655-672(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP FUNCTION.
RX PubMed=9450541; DOI=10.1016/s0014-5793(97)01478-6;
RA de la Fuente N., Maldonado A.M., Portillo F.;
RT "Yeast gene YOR137c is involved in the activation of the yeast plasma
RT membrane H+-ATPase by glucose.";
RL FEBS Lett. 420:17-19(1997).
RN [5]
RP INDUCTION BY ETHANOL.
RX PubMed=11389906; DOI=10.1016/s0014-5793(01)02503-0;
RA Alexandre H., Ansanay-Galeote V., Dequin S., Blondin B.;
RT "Global gene expression during short-term ethanol stress in Saccharomyces
RT cerevisiae.";
RL FEBS Lett. 498:98-103(2001).
CC -!- FUNCTION: Involved in the activation of the plasma membrane proton-
CC ATPase (PMA1) by glucose. {ECO:0000269|PubMed:9450541}.
CC -!- INDUCTION: Up-regulated by ethanol. {ECO:0000269|PubMed:11389906}.
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DR EMBL; X94335; CAA64055.1; -; Genomic_DNA.
DR EMBL; Z75045; CAA99336.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA10910.1; -; Genomic_DNA.
DR PIR; S61692; S61692.
DR RefSeq; NP_014780.3; NM_001183556.3.
DR AlphaFoldDB; Q12212; -.
DR BioGRID; 34532; 45.
DR MINT; Q12212; -.
DR STRING; 4932.YOR137C; -.
DR MaxQB; Q12212; -.
DR PaxDb; Q12212; -.
DR PRIDE; Q12212; -.
DR EnsemblFungi; YOR137C_mRNA; YOR137C; YOR137C.
DR GeneID; 854305; -.
DR KEGG; sce:YOR137C; -.
DR SGD; S000005663; SIA1.
DR VEuPathDB; FungiDB:YOR137C; -.
DR eggNOG; KOG1432; Eukaryota.
DR GeneTree; ENSGT00940000176373; -.
DR HOGENOM; CLU_033929_0_0_1; -.
DR InParanoid; Q12212; -.
DR OMA; HEHGNDC; -.
DR BioCyc; YEAST:G3O-33659-MON; -.
DR PRO; PR:Q12212; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q12212; protein.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IBA:GO_Central.
DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IBA:GO_Central.
DR GO; GO:1902600; P:proton transmembrane transport; IMP:SGD.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; SSF56300; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..622
FT /note="Protein SIA1"
FT /id="PRO_0000042719"
SQ SEQUENCE 622 AA; 71846 MW; 8DE06835FE88FB14 CRC64;
MRLHYRRRFN FLRRILFILC ITSLYLSRDS LKLHAKNVLM DHNVAEYHGG MIDDIQILRC
YHWYRQCSSL YAPKLHPSNT AKKIKDKNSI LWTRVSKNIT VETLYSLQSG PFYNSYLYVH
LKDFQSNPKN TIKELAIARD SALIPLQVLR DINKLVKSSD SSVFHNHVYL REKPTSSWWK
LLFGISVDTD NIAVFGEEWV YKGSGIWCKY ILNDDDNDAP ITNLEIYLGS SFIESRPSWK
EVIHEFHRNN IPSLPISITR KLETKNHHHK FSNGLLGSLR TPSKDINIQV DADYKITSPH
IQFSRGQRSF KILQITDFHF KCTDNSMTVI NEIKTVNFID RVLASENPDL VVITGDLLDS
HNTIDYQTCI MKVVQPMISN KIPYAISLGV SDESNLATSA QIRDFIRNLP YTFNNVASEE
GHMAIEVSFK KKLTKNTLLE RDIDTEDETN PSEALFFVFD SFAPVNNFLQ DYNDLIGKID
FGLAFQYFPL SEYRPHGLFP IIGQYNERST LTVDTPRSRG QVSMTINGKH YKSFLDILSL
WNIKGVSCGH EHNNDCCLQS KNEMWLCYGG SAGIGLPRIQ GIYPTVRLFN LDDILDEITS
WKRNSNLVDE VYDYQYIYKG KQ
