BH060_ARATH
ID BH060_ARATH Reviewed; 426 AA.
AC Q3EAI1; Q8LDR2; Q8S3E2; Q9M2R7; Q9SVZ4;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Transcription factor bHLH60;
DE AltName: Full=Basic helix-loop-helix protein 60;
DE Short=AtbHLH60;
DE Short=bHLH 60;
DE AltName: Full=Transcription factor EN 91;
DE AltName: Full=bHLH transcription factor bHLH060;
GN Name=BHLH60; Synonyms=EN91; OrderedLocusNames=At3g57800;
GN ORFNames=F15B8.10, T10K17.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, GENE FAMILY,
RP AND NOMENCLATURE.
RC STRAIN=cv. Columbia; TISSUE=Flower;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 341-426 (ISOFORMS 1/2).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- INTERACTION:
CC Q3EAI1-2; Q9LV17: BHLH79; NbExp=3; IntAct=EBI-15194889, EBI-15191993;
CC Q3EAI1-2; Q9M0B9: IBL1; NbExp=3; IntAct=EBI-15194889, EBI-15192969;
CC Q3EAI1-2; Q9FML4: LOB; NbExp=3; IntAct=EBI-15194889, EBI-15194891;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3EAI1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3EAI1-2; Sequence=VSP_036088;
CC -!- TISSUE SPECIFICITY: Expressed constitutively in roots, leaves, stems,
CC and flowers. {ECO:0000269|PubMed:12679534}.
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DR EMBL; AF488593; AAM10949.1; -; mRNA.
DR EMBL; AL049660; CAB41175.1; -; Genomic_DNA.
DR EMBL; AL132977; CAB67608.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79702.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79703.1; -; Genomic_DNA.
DR EMBL; AY139773; AAM98091.1; -; mRNA.
DR EMBL; BT003037; AAO23602.1; -; mRNA.
DR EMBL; AY085849; AAM67309.1; -; mRNA.
DR PIR; T46002; T46002.
DR RefSeq; NP_567057.2; NM_115642.2. [Q3EAI1-1]
DR RefSeq; NP_850745.1; NM_180414.3. [Q3EAI1-2]
DR AlphaFoldDB; Q3EAI1; -.
DR BioGRID; 10844; 20.
DR IntAct; Q3EAI1; 20.
DR STRING; 3702.AT3G57800.1; -.
DR PaxDb; Q3EAI1; -.
DR PRIDE; Q3EAI1; -.
DR ProteomicsDB; 240875; -. [Q3EAI1-1]
DR EnsemblPlants; AT3G57800.1; AT3G57800.1; AT3G57800. [Q3EAI1-1]
DR EnsemblPlants; AT3G57800.2; AT3G57800.2; AT3G57800. [Q3EAI1-2]
DR GeneID; 825530; -.
DR Gramene; AT3G57800.1; AT3G57800.1; AT3G57800. [Q3EAI1-1]
DR Gramene; AT3G57800.2; AT3G57800.2; AT3G57800. [Q3EAI1-2]
DR KEGG; ath:AT3G57800; -.
DR Araport; AT3G57800; -.
DR TAIR; locus:2076581; AT3G57800.
DR eggNOG; ENOG502QS36; Eukaryota.
DR InParanoid; Q3EAI1; -.
DR OMA; QYQQQWH; -.
DR PhylomeDB; Q3EAI1; -.
DR PRO; PR:Q3EAI1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q3EAI1; baseline and differential.
DR Genevisible; Q3EAI1; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR024097; bHLH_ZIP_TF.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR12565; PTHR12565; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..426
FT /note="Transcription factor bHLH60"
FT /id="PRO_0000358755"
FT DOMAIN 210..307
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 117..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 243..289
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12679534,
FT ECO:0000303|PubMed:14593172"
FT /id="VSP_036088"
FT CONFLICT 368
FT /note="R -> Q (in Ref. 5; AAM67309)"
FT /evidence="ECO:0000305"
FT CONFLICT 392
FT /note="E -> K (in Ref. 5; AAM67309)"
FT /evidence="ECO:0000305"
FT CONFLICT 405
FT /note="A -> T (in Ref. 1; AAM10949)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 426 AA; 46575 MW; A30736E5246EFF05 CRC64;
MDLTGGFGAR SGGVGPCREP IGLESLHLGD EFRQLVTTLP PENPGGSFTA LLELPPTQAV
ELLHFTDSSS SQQAAVTGIG GEIPPPLHSF GGTLAFPSNS VLMERAARFS VIATEQQNGN
ISGETPTSSV PSNSSANLDR VKTEPAETDS SQRLISDSAI ENQIPCPNQN NRNGKRKDFE
KKGKSSTKKN KSSEENEKLP YVHVRARRGQ ATDSHSLAER ARREKINARM KLLQELVPGC
DKGTDFGGKI KIKVCFGVHL LMISGKKVAI FLWKVSCEDL IDCSFSPPRI QGTALVLDEI
INHVQSLQRQ VEMLSMRLAA VNPRIDFNLD TILASENGSL MDGSFNAAPM QLAWPQQAIE
TEQSFHHRQL QQPPTQQWPF DGLNQPVWGR EEDQAHGNDN SNLMAVSENV MVASANLHPN
QVKMEL