BH061_ARATH
ID BH061_ARATH Reviewed; 315 AA.
AC Q9LXA9; Q8S3E1;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Transcription factor bHLH61;
DE AltName: Full=Basic helix-loop-helix protein 61;
DE Short=AtbHLH61;
DE Short=bHLH 61;
DE AltName: Full=Transcription factor EN 46;
DE AltName: Full=bHLH transcription factor bHLH061;
GN Name=BHLH61; Synonyms=EN46; OrderedLocusNames=At5g10570;
GN ORFNames=F12B17.80;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia; TISSUE=Flower;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed constitutively in leaves and flowers.
CC {ECO:0000269|PubMed:12679534}.
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DR EMBL; AF488594; AAM10950.1; -; mRNA.
DR EMBL; AL353995; CAB89386.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91564.1; -; Genomic_DNA.
DR PIR; T49982; T49982.
DR RefSeq; NP_196619.1; NM_121095.4.
DR AlphaFoldDB; Q9LXA9; -.
DR SMR; Q9LXA9; -.
DR BioGRID; 16200; 16.
DR IntAct; Q9LXA9; 15.
DR STRING; 3702.AT5G10570.1; -.
DR iPTMnet; Q9LXA9; -.
DR PaxDb; Q9LXA9; -.
DR PRIDE; Q9LXA9; -.
DR EnsemblPlants; AT5G10570.1; AT5G10570.1; AT5G10570.
DR GeneID; 830922; -.
DR Gramene; AT5G10570.1; AT5G10570.1; AT5G10570.
DR KEGG; ath:AT5G10570; -.
DR Araport; AT5G10570; -.
DR TAIR; locus:2142419; AT5G10570.
DR eggNOG; ENOG502QQHH; Eukaryota.
DR HOGENOM; CLU_035660_1_0_1; -.
DR InParanoid; Q9LXA9; -.
DR OMA; QASCFEV; -.
DR OrthoDB; 1023623at2759; -.
DR PhylomeDB; Q9LXA9; -.
DR PRO; PR:Q9LXA9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LXA9; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..315
FT /note="Transcription factor bHLH61"
FT /id="PRO_0000358756"
FT DOMAIN 147..196
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 56..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..81
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 19
FT /note="V -> A (in Ref. 1; AAM10950)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 315 AA; 35554 MW; ADFEEFE68658C745 CRC64;
METELTQLRK QESNNLNGVN GGFMAIDQFV PNDWNFDYLC FNNLLQEDDN IDHPSSSSLM
NLISQPPPLL HQPPQPSSPL YDSPPLSSAF DYPFLEDIIH SSYSPPPLIL PASQENTNNY
SPLMEESKSF ISIGETNKKR SNKKLEGQPS KNLMAERRRR KRLNDRLSLL RSIVPKITKM
DRTSILGDAI DYMKELLDKI NKLQEDEQEL GSNSHLSTLI TNESMVRNSL KFEVDQREVN
THIDICCPTK PGLVVSTVST LETLGLEIEQ CVISCFSDFS LQASCFEVGE QRYMVTSEAT
KQALIRNAGY GGRCL
