BH062_ARATH
ID BH062_ARATH Reviewed; 456 AA.
AC Q9SRT2; Q67Y05; Q8S3E0;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Transcription factor bHLH62;
DE AltName: Full=Basic helix-loop-helix protein 62;
DE Short=AtbHLH62;
DE Short=bHLH 62;
DE AltName: Full=Transcription factor EN 85;
DE AltName: Full=bHLH transcription factor bHLH062;
GN Name=BHLH62; Synonyms=CIB3, EN85; OrderedLocusNames=At3g07340;
GN ORFNames=F21O3.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 3-456, TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [6]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed constitutively in roots, leaves, stems,
CC and flowers. {ECO:0000269|PubMed:12679534}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM10951.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC009853; AAF02164.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74530.1; -; Genomic_DNA.
DR EMBL; AK175369; BAD43132.1; -; mRNA.
DR EMBL; AK175496; BAD43259.1; -; mRNA.
DR EMBL; AK176563; BAD44326.1; -; mRNA.
DR EMBL; AK176663; BAD44426.1; -; mRNA.
DR EMBL; BT026497; ABH04604.1; -; mRNA.
DR EMBL; AF488595; AAM10951.1; ALT_INIT; mRNA.
DR RefSeq; NP_187390.1; NM_111613.5.
DR AlphaFoldDB; Q9SRT2; -.
DR SMR; Q9SRT2; -.
DR BioGRID; 5257; 9.
DR IntAct; Q9SRT2; 5.
DR STRING; 3702.AT3G07340.1; -.
DR iPTMnet; Q9SRT2; -.
DR PaxDb; Q9SRT2; -.
DR PRIDE; Q9SRT2; -.
DR ProteomicsDB; 240404; -.
DR EnsemblPlants; AT3G07340.1; AT3G07340.1; AT3G07340.
DR GeneID; 819922; -.
DR Gramene; AT3G07340.1; AT3G07340.1; AT3G07340.
DR KEGG; ath:AT3G07340; -.
DR Araport; AT3G07340; -.
DR TAIR; locus:2079676; AT3G07340.
DR eggNOG; ENOG502QRSF; Eukaryota.
DR HOGENOM; CLU_025018_6_0_1; -.
DR InParanoid; Q9SRT2; -.
DR OMA; IHMGFAQ; -.
DR OrthoDB; 616690at2759; -.
DR PhylomeDB; Q9SRT2; -.
DR PRO; PR:Q9SRT2; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SRT2; baseline and differential.
DR Genevisible; Q9SRT2; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR024097; bHLH_ZIP_TF.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR12565; PTHR12565; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..456
FT /note="Transcription factor bHLH62"
FT /id="PRO_0000358757"
FT DOMAIN 264..314
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 159..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 421
FT /note="E -> G (in Ref. 3; BAD44326/BAD44426)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 456 AA; 50247 MW; 02D38D2E3BD22821 CRC64;
MENELFMNAG VSHPPVMTSP SSSSAMLKWV SMETQPVDPS LSRNLFWEKS TEQSIFDSAL
SSLVSSPTPS NSNFSVGGVG GENVIMRELI GKLGNIGDIY GITASNGNSC YATPMSSPPP
GSMMETKTTT PMAELSGDPG FAERAARFSC FGSRSFNSRT NSPFPINNEP PITTNEKMPR
VSSSPVFKPL ASHVPAGESS GELSRKRKTK SKQNSPSAVS SSKEIEEKED SDPKRCKKSE
ENGDKTKSID PYKDYIHVRA RRGQATDSHS LAERVRREKI SERMKLLQDL VPGCNKVTGK
ALMLDEIINY VQSLQRQVEF LSMKLSSVNT RLDFNMDALL SKDIFPSSNN LMHHQQVLQL
DSSAETLLGD HHNKNLQLNP DISSNNVINP LETSETRSFI SHLPTLAHFT DSISQYSTFS
EDDLHSIIHM GFAQNRLQEL NQGSSNQVPS HMKAEL
