ID   SIAE_PONAB              Reviewed;         523 AA.
AC   Q5RFU0;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Sialate O-acetylesterase;
DE            EC=3.1.1.53;
DE   AltName: Full=Sialic acid-specific 9-O-acetylesterase;
DE   Flags: Precursor;
GN   Name=SIAE; Synonyms=YSG2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the removal of O-acetyl ester groups from position
CC       9 of the parent sialic acid, N-acetylneuraminic acid. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N-
CC         acetylneuraminate; Xref=Rhea:RHEA:22600, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:28999, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:35418; EC=3.1.1.53;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N-
CC         acetylneuraminate; Xref=Rhea:RHEA:25564, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29006, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:35418; EC=3.1.1.53;
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000250}.
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DR   EMBL; CR857060; CAH89367.1; -; mRNA.
DR   RefSeq; NP_001124572.1; NM_001131100.1.
DR   AlphaFoldDB; Q5RFU0; -.
DR   SMR; Q5RFU0; -.
DR   STRING; 9601.ENSPPYP00000004592; -.
DR   GeneID; 100171407; -.
DR   KEGG; pon:100171407; -.
DR   CTD; 54414; -.
DR   eggNOG; ENOG502QUKD; Eukaryota.
DR   InParanoid; Q5RFU0; -.
DR   OrthoDB; 745508at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0106331; F:sialate 4-O-acetylesterase activity; IEA:UniProtKB-EC.
DR   GO; GO:0106330; F:sialate 9-O-acetylesterase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.1110; -; 1.
DR   InterPro; IPR005181; SASA.
DR   InterPro; IPR036514; SGNH_hydro_sf.
DR   InterPro; IPR039329; SIAE.
DR   PANTHER; PTHR22901; PTHR22901; 1.
DR   Pfam; PF03629; SASA; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Hydrolase; Lysosome; Reference proteome; Serine esterase;
KW   Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..523
FT                   /note="Sialate O-acetylesterase"
FT                   /id="PRO_0000042242"
FT   CARBOHYD        107
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        138
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        267
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        290
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        401
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        422
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   523 AA;  58386 MW;  FB0D38849C48C793 CRC64;
     MVAPGLVLGL VLPLILWADR SAGIGFRFAS YINNDMVLQK EPAGAVIWGF GTPGATVTVT
     LRQGRETIMK KVTSVKAHSD TWMVVLDPMK PGGPFEVMAQ QTLEKINFTL RVHDVLFGDV
     WLCSGQSNMQ MTVLQIFNAT RELSNTAAYQ SVRILSVSPT QAEQELEDLV AVDLQWSKPT
     SENLGHGYFK YMSAVCWLFG RHLYDTLQYP IGLIASSWGG TPIEAWSSGR SLKACGVPKQ
     GSVPYDSVTG PSKHSVLWNA MIHPLCNMTL KGVVWYQGES NINYNTDLYN CTFPALIEDW
     RETFHRGSQG QTERFFPFGL VQLSSDLSKK SSDDGFPQIR WHQTADFGYV PNPKMPNTFM
     AVAMDLCDRD SPFGSIHPRD KQTVAYRLHL GARALAYGEK NLTFEGPLPE KIELLAHKGL
     LNLTYYQQIQ VQKKDNKIFE ISCCSDRRCK WLPASMSTVS TQSLTLAIDS CRGTVVALRY
     AWTTWPCEYK QCPLYHPSSA LPAPPFIAFI TDQDPGHQSN VAK