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SIAQ_VIBCH
ID   SIAQ_VIBCH              Reviewed;         173 AA.
AC   Q9KR65;
DT   20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Sialic acid TRAP transporter small permease protein SiaQ {ECO:0000305};
GN   Name=siaQ {ECO:0000303|PubMed:22167185};
GN   OrderedLocusNames=VC_1778 {ECO:0000312|EMBL:AAF94927.1};
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
RN   [2]
RP   FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RX   PubMed=22167185; DOI=10.1074/jbc.m111.281030;
RA   Mulligan C., Leech A.P., Kelly D.J., Thomas G.H.;
RT   "The membrane proteins SiaQ and SiaM form an essential stoichiometric
RT   complex in the sialic acid tripartite ATP-independent periplasmic (TRAP)
RT   transporter SiaPQM (VC1777-1779) from Vibrio cholerae.";
RL   J. Biol. Chem. 287:3598-3608(2012).
RN   [3]
RP   FUNCTION.
RX   PubMed=22556361; DOI=10.1099/mic.0.059659-0;
RA   Chowdhury N., Norris J., McAlister E., Lau S.Y., Thomas G.H., Boyd E.F.;
RT   "The VC1777-VC1779 proteins are members of a sialic acid-specific subfamily
RT   of TRAP transporters (SiaPQM) and constitute the sole route of sialic acid
RT   uptake in the human pathogen Vibrio cholerae.";
RL   Microbiology 158:2158-2167(2012).
CC   -!- FUNCTION: Part of the tripartite ATP-independent periplasmic (TRAP)
CC       transport system SiaPQM that catalyzes unidirectional Na(+)-dependent
CC       sialic acid uptake. {ECO:0000269|PubMed:22167185,
CC       ECO:0000269|PubMed:22556361}.
CC   -!- SUBUNIT: The complex comprises the extracytoplasmic solute receptor
CC       protein SiaP, and the two transmembrane proteins SiaQ and SiaM. SiaQ
CC       and SiaM form a tight 1:1 complex. {ECO:0000269|PubMed:22167185}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000269|PubMed:22167185}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TRAP transporter small permease family.
CC       {ECO:0000305}.
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DR   EMBL; AE003852; AAF94927.1; -; Genomic_DNA.
DR   PIR; G82157; G82157.
DR   RefSeq; NP_231413.1; NC_002505.1.
DR   RefSeq; WP_001889698.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9KR65; -.
DR   STRING; 243277.VC_1778; -.
DR   DNASU; 2613658; -.
DR   EnsemblBacteria; AAF94927; AAF94927; VC_1778.
DR   GeneID; 57740422; -.
DR   KEGG; vch:VC_1778; -.
DR   PATRIC; fig|243277.26.peg.1698; -.
DR   eggNOG; COG3090; Bacteria.
DR   HOGENOM; CLU_086356_9_2_6; -.
DR   OMA; RFSLIWM; -.
DR   BioCyc; VCHO:VC1778-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015740; P:C4-dicarboxylate transport; IBA:GO_Central.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   InterPro; IPR007387; TRAP_DctQ.
DR   PANTHER; PTHR35011; PTHR35011; 1.
DR   Pfam; PF04290; DctQ; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..173
FT                   /note="Sialic acid TRAP transporter small permease protein
FT                   SiaQ"
FT                   /id="PRO_0000435367"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   173 AA;  19502 MW;  F5D6731C6C1FECF5 CRC64;
     MELKMLRKII NNIEEIITVP LMAALLAVLT WQIGTRWLLN DPSLWSEELA RLLFMYMCLV
     GCAIAIKRSS HVNITFFSDK LPEKARLSLV LSLEIAVLVS IGAIIVLGYQ HAQRNAFFEL
     ITLGISSSWM NYSLPVGGVF MVFRQLEKIF NLMKLLLGVS SSASLIDQQV TER
 
 
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