BH070_ARATH
ID BH070_ARATH Reviewed; 371 AA.
AC O81037;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Transcription factor bHLH70;
DE AltName: Full=Basic helix-loop-helix protein 70;
DE Short=AtbHLH70;
DE Short=bHLH 70;
DE AltName: Full=Transcription factor EN 13;
DE AltName: Full=bHLH transcription factor bHLH070;
GN Name=BHLH70; Synonyms=EN13; OrderedLocusNames=At2g46810; ORFNames=F19D11.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 228-371, TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia; TISSUE=Stem;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [4]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed constitutively in roots, leaves, stems,
CC and flowers. {ECO:0000269|PubMed:12679534}.
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DR EMBL; AC005310; AAC33499.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10757.1; -; Genomic_DNA.
DR EMBL; AF488602; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; T02682; T02682.
DR RefSeq; NP_182204.1; NM_130247.3.
DR AlphaFoldDB; O81037; -.
DR SMR; O81037; -.
DR STRING; 3702.AT2G46810.1; -.
DR PaxDb; O81037; -.
DR PRIDE; O81037; -.
DR ProteomicsDB; 240763; -.
DR EnsemblPlants; AT2G46810.1; AT2G46810.1; AT2G46810.
DR GeneID; 819294; -.
DR Gramene; AT2G46810.1; AT2G46810.1; AT2G46810.
DR KEGG; ath:AT2G46810; -.
DR Araport; AT2G46810; -.
DR TAIR; locus:2044387; AT2G46810.
DR eggNOG; ENOG502QSKY; Eukaryota.
DR HOGENOM; CLU_044652_2_0_1; -.
DR InParanoid; O81037; -.
DR OrthoDB; 1153031at2759; -.
DR PhylomeDB; O81037; -.
DR PRO; PR:O81037; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O81037; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IPI:TAIR.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009631; P:cold acclimation; IMP:TAIR.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..371
FT /note="Transcription factor bHLH70"
FT /id="PRO_0000358764"
FT DOMAIN 190..241
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 149..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 371 AA; 43001 MW; D54B5D9D09BDD05F CRC64;
MFVLRVSNQS FKLHQQVQCK DEIFCLDQKV NVRRSLQVQE TVEDHQSFAL EEEEQQLSTP
SLLQDTTIPF LQMLQQSEDP SPFLSFKDPS FLALLSLQTL EKPWELENYL PHEVPEFHSP
IHSETNHYYH NPSLEGVNEA ISNQELPFNP LENARSRRKR KNNNLASLMT REKRKRRRTK
PTKNIEEIES QRMTHIAVER NRRRQMNVHL NSLRSIIPSS YIQRGDQASI VGGAIDFVKI
LEQQLQSLEA QKRSQQSDDN KEQIPEDNSL RNISSNKLRA SNKEEQSSKL KIEATVIESH
VNLKIQCTRK QGQLLRSIIL LEKLRFTVLH LNITSPTNTS VSYSFNLKME DECNLGSADE
ITAAIRQIFD S
