ID   SIAT_HAEI8              Reviewed;         616 AA.
AC   Q4QP40;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Sialic acid TRAP transporter permease protein SiaT;
DE   AltName: Full=N-acetylneuraminic acid permease;
DE   AltName: Full=N-acetylneuraminic acid transporter;
DE   AltName: Full=Neu5Ac permease;
GN   Name=siaT; OrderedLocusNames=NTHI0234;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=86-028NP;
RX   PubMed=15968074; DOI=10.1128/jb.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable Haemophilus
RT   influenzae: comparative study with H. influenzae serotype d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- FUNCTION: Part of the tripartite ATP-independent periplasmic (TRAP)
CC       transport system SiaPT involved in the uptake of sialic acid.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The complex comprises the extracytoplasmic solute receptor
CC       protein SiaP, and the fused transmembrane protein SiaT. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the TRAP transporter
CC       small permease family. {ECO:0000305}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the TRAP transporter
CC       large permease family. {ECO:0000305}.
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DR   EMBL; CP000057; AAX87207.1; -; Genomic_DNA.
DR   RefSeq; WP_011271902.1; NC_007146.2.
DR   AlphaFoldDB; Q4QP40; -.
DR   EnsemblBacteria; AAX87207; AAX87207; NTHI0234.
DR   KEGG; hit:NTHI0234; -.
DR   HOGENOM; CLU_019824_4_1_6; -.
DR   OMA; GMGHVNI; -.
DR   OrthoDB; 903568at2; -.
DR   Proteomes; UP000002525; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010656; DctM.
DR   InterPro; IPR004681; TRAP_DctM.
DR   InterPro; IPR007387; TRAP_DctQ.
DR   PANTHER; PTHR33362; PTHR33362; 1.
DR   Pfam; PF06808; DctM; 1.
DR   Pfam; PF04290; DctQ; 1.
DR   TIGRFAMs; TIGR00786; dctM; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..616
FT                   /note="Sialic acid TRAP transporter permease protein SiaT"
FT                   /id="PRO_0000238447"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        332..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        459..479
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        505..525
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        527..547
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        552..572
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        587..607
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..190
FT                   /note="TRAP transporter small permease"
FT   REGION          191..616
FT                   /note="TRAP transporter large permease"
SQ   SEQUENCE   616 AA;  67739 MW;  E0A0650FD9D10DEC CRC64;
     MKYINKLEEW LGGTLFIAIF GILIAQILSR QVFHSPLIWS EELAKLLFVY VGMLGISVAV
     RKQEHVFIDF LTNLMPEKIR KFTNTFVQLL VFVCIFLFIH FGIRTFNDAS FPIDALGGIS
     EKWIFAALPV IAILMMFRFI QAQTINFKTG KSYLPATFFI ISAVILFAIL FFAPDWFKVL
     RISNYIKLGS SSVYIALLVW LIIMFIGVPV GWSLFIATLL YFSMTRWNVV NAATEKLVYS
     LDSFPLLAVP FYILTGILMN TGGITERIFN FAKSLLGHYT GGMGHVNIGA SLLFSGMSGS
     ALADAGGLGQ LEIKAMRDAG YDDDICGGIT AASCIIGPLV PPSIAMIIYG VIANESIAKL
     FIAGFIPGVL ITLALMAMNY RIAKKRGYPR TPKATREQLC SSFKQSFWAI LTPLLIIGGI
     FSGLFSPTES AIVAAAYSII IGKFVYKELT LKTLFNSCIE AMAITGVVAL MIMTVTFFGD
     MIAREQVAMR VADVFVAVAD SPLTVLVMIN ALLLFLGMFI DALALQFLVL PMLIPIAMQF
     NIDLIFFGVM TTLNMMIGIL TPPMGMALFV VARVGNMSVS TVTKGVLPFL IPVFVTLVLI
     TIFPQIITFV PNLLIP