ID   SIB1_SCHPO              Reviewed;        4924 AA.
AC   Q9P7T1;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Hydroxamate-type ferrichrome siderophore peptide synthetase;
DE            EC=6.-.-.-;
GN   Name=sib1; ORFNames=SPAC23G3.02c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=15689108; DOI=10.1007/s10534-004-1230-z;
RA   Schrettl M., Winkelmann G., Haas H.;
RT   "Ferrichrome in Schizosaccharomyces pombe -- an iron transport and iron
RT   storage compound.";
RL   BioMetals 17:647-654(2004).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Involved in intracellular and extracellular ferrichrome
CC       siderophore biosynthesis. {ECO:0000269|PubMed:15689108}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000305}.
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DR   EMBL; CU329670; CAB72227.1; -; Genomic_DNA.
DR   PIR; T50176; T50176.
DR   RefSeq; NP_593102.1; NM_001018499.2.
DR   SMR; Q9P7T1; -.
DR   BioGRID; 277956; 12.
DR   STRING; 4896.SPAC23G3.02c.1; -.
DR   MaxQB; Q9P7T1; -.
DR   PaxDb; Q9P7T1; -.
DR   PRIDE; Q9P7T1; -.
DR   EnsemblFungi; SPAC23G3.02c.1; SPAC23G3.02c.1:pep; SPAC23G3.02c.
DR   GeneID; 2541451; -.
DR   KEGG; spo:SPAC23G3.02c; -.
DR   PomBase; SPAC23G3.02c; sib1.
DR   VEuPathDB; FungiDB:SPAC23G3.02c; -.
DR   eggNOG; KOG1178; Eukaryota.
DR   HOGENOM; CLU_000092_2_0_1; -.
DR   InParanoid; Q9P7T1; -.
DR   OMA; QACSQAF; -.
DR   PhylomeDB; Q9P7T1; -.
DR   PRO; PR:Q9P7T1; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0016879; F:ligase activity, forming carbon-nitrogen bonds; IC:PomBase.
DR   GO; GO:1904091; F:peptidyl carrier protein activity; NAS:PomBase.
DR   GO; GO:0031177; F:phosphopantetheine binding; IBA:GO_Central.
DR   GO; GO:0043041; P:amino acid activation for nonribosomal peptide biosynthetic process; IBA:GO_Central.
DR   GO; GO:0010106; P:cellular response to iron ion starvation; IGI:PomBase.
DR   GO; GO:0031169; P:ferrichrome biosynthetic process; IMP:PomBase.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IBA:GO_Central.
DR   Gene3D; 1.10.1200.10; -; 2.
DR   Gene3D; 3.30.300.30; -; 2.
DR   Gene3D; 3.30.559.10; -; 6.
DR   Gene3D; 3.40.50.12780; -; 3.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   Pfam; PF00501; AMP-binding; 4.
DR   Pfam; PF00668; Condensation; 6.
DR   Pfam; PF00550; PP-binding; 3.
DR   SMART; SM00823; PKS_PP; 2.
DR   SUPFAM; SSF47336; SSF47336; 4.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 1.
DR   PROSITE; PS00455; AMP_BINDING; 2.
DR   PROSITE; PS50075; CARRIER; 4.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   1: Evidence at protein level;
KW   Cytoplasm; Ligase; Phosphopantetheine; Phosphoprotein; Reference proteome;
KW   Repeat.
FT   CHAIN           1..4924
FT                   /note="Hydroxamate-type ferrichrome siderophore peptide
FT                   synthetase"
FT                   /id="PRO_0000339124"
FT   DOMAIN          715..791
FT                   /note="Carrier 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   DOMAIN          2172..2246
FT                   /note="Carrier 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   DOMAIN          3254..3328
FT                   /note="Carrier 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   DOMAIN          4402..4478
FT                   /note="Carrier 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         752
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         2206
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         3288
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         4439
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
SQ   SEQUENCE   4924 AA;  559849 MW;  985D30FED3406E2C CRC64;
     MKNSNEEDAF STQISQLGPM RPSSDAPYHV LSLPFSHPYS AFLDAWSWLF CGITGGEVSF
     FFFPVSDDVI PNTNPKNCQC YLYHSTNSQL EPLEVFHLHK LHSAVFTSRR DPSFADDLFE
     SSKPCLNQLL SYFSDITAFR SMDVVADIAF VCSPNFLTLK WNSSLFDDDL ARLLFFMINS
     KITNYDLPFS ILNSPCSDLC LNSSSLANYL HGCFYHNTLS HPYQDALKFI YEIGDDLEDT
     FRSFSFLELH SLAIKLSKLV TCKNEVVPIM VSHSPALFVG ILAILYSGNA YCPIDVETRT
     ERVHFISKDV DASFAIVSEE FVNRFPNNTI ILKVPEYNES MEIKVDDEIP PFPFPESLDS
     VAYVLYTSGS TGNPKGVAIS HRAATNSIKS HGYLYPMFGL ERGDAWLQFA NVTFDVSVFE
     IFGNWNNGLT LVTSKRQNLI GNLEYLIYDY KIAALELTPT VANVISLDEN KELFTSVRML
     ITIGELLTNR IIDFWGERLV NAYGPTEAAI HVTLNPSKAL TTVYLVGVPL QSATICVVSL
     PTEDSQPHVL HEGFLGEVCI AGPQLSSGYI NRPEINAKAF VEVQYNEQTL SIYRTGDLGR
     IINGKLYIFG RIAGDMQIKI RGRRIEIGEI ESKLAPSVDS LAIEKIGDNL VAFYVGDEMK
     LRKHAESHLA SWMCPTKYVG LPGFPRLASG KTDRKALKIQ FSASDKHSTD FSSFNQSELL
     VANVLHEICE KRFNSVVSIS RFSSIFDLGL DSLDIVYFVR KIRSLGFEAN PSIVLTSKVV
     FKIAESLILL KPNEVQSKNN FLNKCTPLQK GMLYESFSNN GNLYFNHTVF KIAASPEKVK
     LAWEKLLDTH TILSNGFALD ENEGFTRFIL EKKPPLYSYS KNCLECIQKH FTTKEFDEQF
     LNSGPLDAAV IYDSSNCYLS IVWHHALYDG WSIDIIMQQL FMLIHDRRLT IVPQFEDYVQ
     ELESLRRLNY KNCISFWKKY LKDFKFKSLS YQREKMGVVE LSSNISLLSV ENICKQLQTT
     PLSFFLTAWS TVLSSYLKTN DFLVGTVVSG RVNSLLPNVD YVIGPCMQTL PVRIKLDDEL
     SYKNLCQNLF KELSFVLKHS VMAISDFQEE LLVSNLFESI LIYQQSGIPS VDESFISLIH
     STDHVEQPLL IEIEKNKGYK FKLTGYLSSE LLNNLLNDFD KILNFILYNI ESKIQTHASF
     NVTITEHNHV ESKARTGFSK REEKLVRSCL SKILGNTVLS ADVFENLQNY GFDSLCAMRF
     FSLLRKSSGI GNLKIPNMKS NPTIASLCEL LVLPTETLSA DNEITFYEVS DIQHEANLDI
     ESFQYFPCTP MQQALLASSE KNGVEYYYNK YLFETGKSSQ EEIYLLFKTL LNNLPILRTC
     FFVTRSKKYP YCQVVLNEPN FYFQVLPYKG ESLSKYNLAE IPLLDSKKVP IQIFFLQGEN
     KNYVLFCIHH VLYDAWAFQL IMDDINHLLR KENPKGSQSM LKFISYLHRY NKNVDLEIWS
     KIFLGFKPSK FPELCKDINP EQRTYKCNLS ISLSQIDDLC NGFSFTTSTF LQCCWAKTLS
     FLLNSRDICF GNIISGRDVP VDEVVSLVAP TFNSFPLRVL LDSKLSFAEV CGQLQRLKET
     LQEHQMTSVQ SICKSLTVKS LFDTVFIIQP QLLSDRTGPW KLLNESSSMD MRFIIELLLG
     SDDSPLTLVG TGTGKSGKLV CNLYKTILKH YVHYGLSTSV PLYTSLEKHN LISRSPSSPP
     PIHTNFDTNA DIITLFEKEA NEHPSSIALH FVYNVDKENI YSYKFFSEYS IKASYWLHSI
     GIKKNDVVAV FIDKSLDYYS LMLGVLRIGA FFFPLEHCSS LNFAKENLLR TNVKLLIVDK
     FLPFEDVNQV EIDKFRQVVD KLPTVEIPNE SRSSAFIFPS YELAEGLTMM ESSSFMDSII
     SFIDSTCFPS SSRWFQYAPS STACQMFDCF MCWFFGCTLI SGPQLFLKNN LKPLLLATHA
     SHLITTSSIA ASLKGEDIPS IQRLYCYEGP INNYMIKSWG SRLSYIYAFK PLICSCVPAT
     EYLESNIMMV GIPLKGLIFA VVNSDTNTLA PIGSSGELCI ASVKKSGNTM MDSQRVFTFE
     NRSYYRTGDI VRILAGGEFE YIKKKSFIFI DSMPLDIEGK INVDKLRDLL NDDNYIFKVD
     NDEFPKNDNI LDGFQEKVIL TISDFASIPF EKLSLNTKLS TIGIDSISAI QLSKDLREIF
     HLRISALDIL NSSTINSLIR KLKRRRTESH TRNDKIHESI DQFFKDIRKQ ILIPQTLCDK
     IEQILPCLAS QCSMLSRFYT NGGKDYLNYS VFHLQKYNDP LLLRSSWENV ISNVSILRTK
     FQTTKHKRSP FCQVTYSKVD IPWSMELHAA SVEKVLNEYL ELQRRDLLQG KNVLPYSLIF
     VRTFSQETFL IIIMHHALYD ESSLRKILGL VEKSLNSPIG KFNHEPIVRQ IELLKANYEE
     AKAFWIKQLL SFQPTNFPSL TACRIDNEDR MLTKKPCALN YTNLTKWCNA HDVTLQVLGQ
     LVWAKILASY CAENYAVFGT VLSGKSVLTD VDDNIFPTVT TIPCVVKLQG TVEDCLRQLQ
     KFNLDANKFQ FTSLLDIKKW LNLGPSEKLF SSLFSIYVDN DIPLKLFNDE CKAQGFIEFP
     VALEMRFSES TSELTLNSAV NYIPQAHASL ILDQFNAILT TIFNNPLQQI EILENSLPTQ
     LLSIKPAIVG DYPTEIKYLH QFVEYFAQKS PNSCALEFAL DINQDSVQLI RLTYSELNER
     ANKLAHNLKS YGFRVGSIIA VYFDKCIEAF ISMLAILKAG CCFLALDVSA PTERIRYIVT
     DSTAVLVMST GELYTKLLNA SINVTILDAS DPGNYSNNIE NPYTKDFEDS NLAYVLYTSG
     STGKPKGCCL THHNVVQCML AFQDQFAGEW DTNSRFLAFA SFHFDVSVLE QYFSWSTGIT
     LVAAPQSLIL QDLPTAISAL KITHVDLTPS LASILTPKTA PLLRVFITGG EQIKQELLNI
     WGDTRVLYNF WGPTELTIGA SAFRKVPKNA KVSNIGPPFP NCSTYILSKE TKVPVLLGGL
     GEICMGGNQV AKGYLNLPEQ TDAKFYFDRR FNDRIYHTGD LGRLLKDNNS LEFCGRTDDQ
     IKLRGQRIEI GEINAVIKSS SEKILGVYTL AVVHPVLRKQ QLVAFIHVKG ISASHLIVHD
     HKDPSLIGFI NSACKASLAK YMVPSFYVFI SSVPLTPTNK FDKKKVIEEF SRLSLGQLSS
     FAPAREENDN EGSNVVEPKL LKIIADFSDV KVTDISPQTS VFELGLDSIS AVALSGLLRK
     SGYDNANPSL ILTSSTISNL GFALNTQTNE ELEDSIKVNS IIKLPSCSQF PFHQYIELIN
     PCLPLVEGLL FELERSNNEN YYNSFFFLFE KREQADQFIN NFKLLRKQYE VLRSSFLKSD
     GEYFQVVWKS DFIAEVDVLN NDSLIKTVRY SLKCEKGFFL VTVTLFHGIY DGWSLDLLLN
     DLARLCSRKT LAPRPRYSKI VRQLLINTSL KKDTKEYWLN LFRSKNIYVP IFQGKLDMAI
     TLGHKLSISS AKLSTICRSV LKASVNSALL TSWICFLNSI GAINCVGIVV SGRSEISMDC
     LEVMGPLFNT IPFPLFLEKD ESFDCLVRRC QLTLASMIPY HQTSLREIKK WLRRSELFNV
     LFTYNLHPSV IKQCEFPWSF SSESTDTGYP LALEIEEDVD GTMNLHLSSN FKYIGQTEII
     GLLDSYDCYL SSLLETSNAK ISSRPNVLMP NQPEVKQYIP NVWNDVLKKL ITILSPKVII
     TKLDFERDTF VHEFGIDSID LIWLASKVSE AGIGKLDIGL LMEKPTFYRI LQLLCETSAN
     HSTSLKHEFG TLNTLLSKYL TDQDAEDCYP ATPIQSGLLL ETMNQKNLYQ NDVLFSLDAE
     ISLEKLQNSW KRLCQKNAIL RTHFAISEDS SEPMVIQIVD KFEARSCLNQ IKILPSRFTN
     IEDTLRFLRH DEEAKRFLDP FKNPPYYVQF FEIGAKNYMF VQMHHSLYDG WSLSLMYDEL
     MQLYRDEQGN SRKPFKDYII QLYSLKYDYD FWFKYFENLS IPKPLPFLSN NGKFMSSMMS
     TVSLPSVRLA CQLYGVSIQS LVFFTWGYYI ASVLNCPDIV FHTVLSGRTY IEGAETVMGP
     CMNTIPVRIK FEGALQTLKK TSRMLINLAK QQHTPLSWIY KTYGNVAAIP MESILVYQHL
     PDSSQSETFL NVVTDNSAVD YPIAIQFEIQ GDTLNWLTSL DLARVDGDVA NQLLQTIDKI
     FSNLTKGSFE KLTFNFSNFV KYRQYQINLK DFRENLLLTE EAISDCDLLI IDERVLVVFI
     LFPEPDAKFP YLVLNEEIIR MLKSYIKKFR LTLSSAMVPD ILVPVSYLPR SLDHSENEGK
     LLNIYNSISA DNLKILSAVH EIHLNETEKI LLEGFSKIIC LPQDSVDISN NFFQLGMDSI
     RSIHLCSYLR NKGLNVSVSD ILQHSSIEKL AHYLQYEKKE SSSSFDIASF QLDEYLNTLP
     SNIPINLVQK ILPCSAGQMY ALNAWYNTEK KKYFHTFFYT TEEKIELLKL KLAWAKLVKS
     SDILRTTFIR SSSPCYPLLQ IVLKSFECPW EHYITDNLHD TCLKIQKREL VTNTTLQEVP
     LRIATIETSG KFVFCLTIHH ALYDGWSLDI MINYLSKMYY DDSLTIVQQN SQLFLSTVLD
     PAVGLSRKKF WNNYLTNYKP YTFLEKPSAS QEITLFFPKL FSLDTVYSSV RSRGLTVQSV
     SFAVFARLLA NEVKQEDVVF GIYVSGRTLD VDNIDELLFP TFNVVPLRVT DTFRPLGEIA
     LEIQSFLNEI SGNLQYISLL DLPVHGMMDI AVNFLSTGDN NEPSKVFSVY PLKLNNAELK
     INEVETTIDG CEILFGNKPK LDFELAIRDG YLEIGLFCQS SIFSKREASV FINNFVTIIK
     EIEL