SIBA_DICDI
ID SIBA_DICDI Reviewed; 1927 AA.
AC Q54KF7; Q0PL85; Q23848;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Integrin beta-like protein A;
DE AltName: Full=109 gene 1 protein;
DE Flags: Precursor;
GN Name=sibA; ORFNames=DDB_G0287363;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-48, FUNCTION, AND INTERACTION WITH TALA.
RX PubMed=16699495; DOI=10.1038/sj.embor.7400701;
RA Cornillon S., Gebbie L., Benghezal M., Nair P., Keller S.,
RA Wehrle-Haller B., Charette S.J., Brueckert F., Letourneur F., Cosson P.;
RT "An adhesion molecule in free-living Dictyostelium amoebae with integrin
RT beta features.";
RL EMBO Rep. 7:617-621(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1781-1927.
RC STRAIN=AX3;
RX PubMed=2926809; DOI=10.1016/0022-2836(89)90364-1;
RA Giorda R., Ohmachi T., Ennis H.L.;
RT "Organization of a gene family developmentally regulated during
RT Dictyostelium discoideum spore germination.";
RL J. Mol. Biol. 205:63-69(1989).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16512674; DOI=10.1021/pr050350q;
RA Reinders Y., Schulz I., Graef R., Sickmann A.;
RT "Identification of novel centrosomal proteins in Dictyostelium discoideum
RT by comparative proteomic approaches.";
RL J. Proteome Res. 5:589-598(2006).
CC -!- FUNCTION: Implicated in cellular adhesion to substrate or phagocytic
CC particles. {ECO:0000269|PubMed:16699495}.
CC -!- SUBUNIT: Interacts with talA/talin. {ECO:0000269|PubMed:16699495}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SIB family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL63749.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AAFI02000100; EAL63749.1; ALT_SEQ; Genomic_DNA.
DR EMBL; DQ793219; ABG81508.1; -; mRNA.
DR EMBL; M19467; AAA67431.1; -; Genomic_DNA.
DR RefSeq; XP_637266.1; XM_632174.1.
DR AlphaFoldDB; Q54KF7; -.
DR IntAct; Q54KF7; 1.
DR MINT; Q54KF7; -.
DR STRING; 44689.DDB0233521; -.
DR TCDB; 8.A.74.1.1; the tm9 or phg1 targeting receptor (ppg1) family.
DR PaxDb; Q54KF7; -.
DR ABCD; Q54KF7; 6 sequenced antibodies.
DR EnsemblProtists; EAL63749; EAL63749; DDB_G0287363.
DR GeneID; 8626097; -.
DR KEGG; ddi:DDB_G0287363; -.
DR dictyBase; DDB_G0287363; sibA.
DR eggNOG; KOG1218; Eukaryota.
DR InParanoid; Q54KF7; -.
DR PhylomeDB; Q54KF7; -.
DR PRO; PR:Q54KF7; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0009986; C:cell surface; IDA:dictyBase.
DR GO; GO:0005769; C:early endosome; IDA:dictyBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:dictyBase.
DR GO; GO:0055037; C:recycling endosome; IDA:dictyBase.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0031589; P:cell-substrate adhesion; IMP:dictyBase.
DR GO; GO:0006909; P:phagocytosis; IMP:dictyBase.
DR CDD; cd00064; FU; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR SUPFAM; SSF49313; SSF49313; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 1: Evidence at protein level;
KW Cell adhesion; Disulfide bond; EGF-like domain; Glycoprotein; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..1927
FT /note="Integrin beta-like protein A"
FT /id="PRO_0000312331"
FT TOPO_DOM 21..1860
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1861..1881
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1882..1927
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 425..462
FT /note="EGF-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 522..709
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT CARBOHYD 309
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1122
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1516
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1717
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1723
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1855
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 435..450
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 452..461
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1927 AA; 208361 MW; AD03CAB03B1A6D35 CRC64;
MNRILTLFIL FISLFIVCEA THFRFGTMSW MPMGSHNTIK FSSNYAFRIG FFKKFNKGCN
VGDVVKVGDL DLGDDKTKVD VNLVVTSVNQ ADDWFTGEFS YTHTYNPIKL GGKAVTYKVV
FTDCCRIKSL LNNAEGSWYI STSVVVDPNQ GSDVSTFNRS PVSGMVPIIT LNRDKNNQFL
IAASDPNGDT LTYSLSNAYT MNQPSGLSID SSKGIVSFKP TVSGFYSTQI MIKDTKGAYV
VVDFLINSVI EPGVCHPSCS NGGNTCNGNS GCKSCKGTDS NGNTCSSFPP VFVYPPTPTD
GSLLAYEVNK TNSFSIQCKT EEKSKTVFIQ PANIPLAATL TSSDQNKQVS TLTYSMLPQL
KHIGVYVISA YCTDNKGLVS TITSFSISVE KPICGHGTNK PGGGCNCETG WDPEKNCYEC
LKGHYGEKCD PVDPCVNGES NEGSQGNGKC TCYYGWEGKN CDIKVNQVCN ANKENVVLDS
SVAKSSYINP NFAQVYLNTD PSKQALTLSS KLSIPETIDK FEVLVLVDSQ PSIVEYWDNF
KKYSSDLTKN LQDISETVSI GLGLFSDAKT NGYSFVLKKS IGNGLSGLDD KDKAPASSYS
TKNSLIALTS AAEFPAGWST GSIKIIVLLT DNDYSATAQE VSKFTSTLIS KSILPVVVSF
NDNQNWDTLF KNQGFGSTKK TSNAKGNDWV SVATSAIKDV LSKAVVKAID DTKGFLTLPS
ATTISIEDSK DYTIPIQIKY PQGQSDIPQN PSVSYSVVGF GITRIVINYN SAPTALGYSI
ETKQNVNYNF KLSGSDVDGN TLTIKFKTIP AASVGVIQAD GVTIEQGDSF SIEKTFTFKP
ATNYYTKSTN DKFTFVANDG CLDSNEATVE IKITHVNQAP SCSSLSGSAI SVTGLNTPKS
FSLQGSDIET DSNLKIVFGD LTAISAYGNI KSGSNVVSTG SSVQLSSGSA SLTFTQTKDI
ANDKEITVDF KVNDGSLDSS SSCSFKVKFV HFNKPPVAFA VTPLTIRQNS ELKITISASD
SDSDSVIFTL DDLKLGGGDS FFKCDDRSQL TAPFTTQPVS ISGGVASFSE ICYSSPLVNA
NSYASLVFFA NDGQLSSDKF KVLININGDR PNAPPVVNQI PNFTMNEDDI SNELVIDGID
PDELDQGKLK GIIIQKPTNG VILVKSGSST SEAPIIGNAP YKIFYKPNPL YYGTDSFSYT
VEDSMGERDA TPKTTQITVQ HVNHAPTLSI DPYDFTSQTS EKTLELTPKD IDLIDTVFHC
TIVKLPATAI IKTSAGKVID TVPTDLSDNK YIITSNNNIY NDFSDSFDAK CYDSSNAVSN
IATGPITFRY INVPPKAESS DETLNQDSSV SFSVKATDLE DNSNVRAVIR SLPAKGTLTI
KSTGKAAEIS STYAIDDFVY TPVAGYSNWD KPGHVGPADS FNFVAKDSKN DISSNIGTVS
FFIEPRNPPT YEGLAVLYTK ENTDLPFSIS GIVGNGGSNV FLRIKSIVSR GSLYATHCMG
TEGCMSEPNP VDININFTSQ PYTFSFTPIE YENGDNYAII EFVLYDKFNG QEVESQKYTI
IINVIPVNQA PEVILIEHTL STLPNNVIAF DKFKTVKMET NSYVIIKYDG TDIDDPKEKL
KSYIVSPPLR GLLYVYDKDA KDGLGKLIKK DDTFVPVAQD GFWYIVFVPT PGSSGDGYVR
IPISMVDFLG DISVPVTVAV DVSKKNIPPF ITIENKNYTS LANTSIVVTG VSFDDPDSKY
NDVELILSLV NKDGDLVSNK IATFSLSQQS KAKCTKHSEF AQFTCRSNKK TLNALISTMY
VNHQGGGSYR LKVFVNDLGY SSPASIRDKN HMTATDYVEL DVTKPEVTTT KENNNKTVLT
GAIAGAAAGA GLLAAGAWFL LKKSAPPTDA FFGEGAFADG AVSTNPMYEE SGRSAINPLY
EASSENL
