SIBB_DICDI
ID SIBB_DICDI Reviewed; 1941 AA.
AC Q54JE1;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Integrin beta-like protein B;
DE Flags: Precursor;
GN Name=sibB; ORFNames=DDB_G0288103;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP IDENTIFICATION, AND INTERACTION WITH TALA.
RX PubMed=16699495; DOI=10.1038/sj.embor.7400701;
RA Cornillon S., Gebbie L., Benghezal M., Nair P., Keller S.,
RA Wehrle-Haller B., Charette S.J., Brueckert F., Letourneur F., Cosson P.;
RT "An adhesion molecule in free-living Dictyostelium amoebae with integrin
RT beta features.";
RL EMBO Rep. 7:617-621(2006).
CC -!- FUNCTION: Implicated in cellular adhesion. {ECO:0000305}.
CC -!- SUBUNIT: Interacts with talA/talin. {ECO:0000269|PubMed:16699495}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SIB family. {ECO:0000305}.
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DR EMBL; AAFI02000109; EAL63396.1; -; Genomic_DNA.
DR RefSeq; XP_636909.1; XM_631817.1.
DR AlphaFoldDB; Q54JE1; -.
DR IntAct; Q54JE1; 1.
DR MINT; Q54JE1; -.
DR STRING; 44689.DDB0233525; -.
DR PaxDb; Q54JE1; -.
DR EnsemblProtists; EAL63396; EAL63396; DDB_G0288103.
DR GeneID; 8626464; -.
DR KEGG; ddi:DDB_G0288103; -.
DR dictyBase; DDB_G0288103; sibB.
DR HOGENOM; CLU_234725_0_0_1; -.
DR InParanoid; Q54JE1; -.
DR OMA; NIERNDD; -.
DR PhylomeDB; Q54JE1; -.
DR PRO; PR:Q54JE1; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 1: Evidence at protein level;
KW Cell adhesion; Disulfide bond; EGF-like domain; Glycoprotein; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..1941
FT /note="Integrin beta-like protein B"
FT /id="PRO_0000312332"
FT TOPO_DOM 21..1871
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1872..1892
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1893..1941
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 420..457
FT /note="EGF-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 513..696
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT REGION 1921..1941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 1400
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1505
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1530
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1606
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1652
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1738
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1777
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1848
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1866
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1869
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 430..445
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 447..456
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1941 AA; 209827 MW; 92E9BFAEC6750CAB CRC64;
MKNIIKYLFI FLCFLIITEA THFRYGTISW APTTKYNNIK ITVNLAFRTG YWGSVAIGQQ
ISHGNIDFGD NTKTGLTMTV TSKDTDNEWF TATWSGIHEY SPQPTAQTKN YIVVYKDCCR
ISTLLNNGDQ YWHISAGIQI DSSNAFPNVN WSPVTNMMPI VRVIANKNNN FRIIANDQNK
QTALSYKFTD TWTMDQPPGM TVDSINGNCW FLPTKEGLYS TQIKVTDALG AYVVVDFLLQ
TYTEVGKCDP TCSNADASCT SNSQCTKCSN TGSNSINTCT NIQSPPEFII PTPKNGETIL
FPIDKSSEFY LSCKTPYASR TASITTSSIP TELALTTTST GQTNSIKYSW SPKTSSIGSY
VISALCKDSS GLTSEVRSFT IRIEKPECGN GGIKGGDGKC VCIGNWDTIY QCFECKDGFY
GDKCTVLPPC KNGVPNGGVN GDGKCLCNNG WTGSDCSVSN SQSCGSMTSS ILSSSNAVSS
YLNPIKAQVY LANDKKFDFP LVLSIPSTLS KLDVYLLVDA NMNSAATFLN IYNGMDNFIS
SVKKFAEDTQ FGLGIFSDYP SNSITFQPNS NIGSDISSAI REFKPSSYSS SSNGNSLLAA
TQASSAQVGW NSGSFKVIVI ITDIDYQANP TEKSSFTNSL IDKSVVPVVI GFGSPIPNWG
ASISSNGFGY TVQSAITSGD WSTKAAAGIK AVSSKLVYKS GEMANGKSLV TSLPIGETIT
QSTQKTVTIS LLKPATTNIE SPVAKVSVMG YGQTVISINS NRQPTVSNSG FSVDQNSFAT
FKLTGSDADL NILTFKFTSF LDSTAGIITS SSGVDVSTQT NTFYSSTEVF KFTPKKNYIA
TSSISFIAND GCVDSTAATI TITINRINQA PECQPITINA LLNQQVGISL SASDFEDVAS
KIAIFVSNPS PLTVYGSFNY QDKPITTTTT INNPWQLTFK QIVNPPSAIS VGVPFKSRDS
ASLYSKECLI TVNFVHTNEA PISSSLSPVP VNPRDKTTIT LTSTDYDSTS ATFNIKSFTT
GTDGKGTFYI CPQLGDCSCT TTQIKLQKNY VSSAVSYSTN IANLGICFSN DQSSQITDYA
SVTFTSTDNQ GLESLPVTVN INVVGTRPNS PPTIISIPKY SVFQDYKDYD KSSKIIDGTD
TDQDDYDKSQ GVNNLIAVIT EKPKKGTLYL KNDGSVASNS PAPMEIYYVP NPGTFGDDTY
SYKVIDTLQA SSTIATTTVS VIQINHKPSV SADSYSFTSQ DVQFEKSLVT SDFDGDQVNC
QVIALPNQIS MYDSEGILIT QVPAKLSKNS YSFRLLDPSL IIPSPFSNVQ SQFTVNCLDV
TSKTDPFGPL QSDDLIVNVG YIYINTPPKT KTLTVQLDQD TSKAFTFNGD DIETPTSDLK
VKIFSLPTNG RLSNQYGYLN GTSISSRTYY LNELTYTPNA GLSNWDTEDN NSPLDKISYA
VLDKGGLSSE TDLVYFSVRP RNPPIYTGKD EINVLQNTRY PLTIIGEIGN GGSSVAISVV
SFTGNGTLYE TFNMGSEGTI DRQISSYPVN RSDSLVGSYF YAYKPPHNQY GDDFDTITFV
LIDGDLVSKI YTVTVNVIHV NQPPTIKLIS YKVLGGSGKE IEFGSNSTVN MNINTMALVK
YIGNDIDKDQ VGPLGSKVLN IPLTGTIYKF NNETTPLGAI IKDKNLNIER NDDGFYYFVF
VPIKGSTGQG YARVPLIVID DGGLVSPSES VDFNVNNINI PPVITIDKEK RSYSLLTNLT
ISATKITFDD PDSKNNDVSI TISIVGEKDE TVVPFSNVSF TVTTGKATCK PDSTLSSITC
VGKKSELNKV ISKIDIIAKV AGNYRLKVFV DDLGYNSPIS IRSSTHLNAT DYVTLQISSP
EVTTQNSSNK TVLSGAIAGA AAGTALIAAA MWKMLRKAAP PTDAFFDEGA FLGDGVNSNP
MYQESKNGGE NPLYLASNET L
