SIBD_DICDI
ID SIBD_DICDI Reviewed; 1957 AA.
AC Q54JA4;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Integrin beta-like protein D;
DE Flags: Precursor;
GN Name=sibD; ORFNames=DDB_G0288197;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP IDENTIFICATION, AND INTERACTION WITH TALA.
RX PubMed=16699495; DOI=10.1038/sj.embor.7400701;
RA Cornillon S., Gebbie L., Benghezal M., Nair P., Keller S.,
RA Wehrle-Haller B., Charette S.J., Brueckert F., Letourneur F., Cosson P.;
RT "An adhesion molecule in free-living Dictyostelium amoebae with integrin
RT beta features.";
RL EMBO Rep. 7:617-621(2006).
CC -!- FUNCTION: Implicated in cellular adhesion. {ECO:0000305}.
CC -!- SUBUNIT: Interacts with talA/talin. {ECO:0000269|PubMed:16699495}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SIB family. {ECO:0000305}.
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DR EMBL; AAFI02000109; EAL63329.1; -; Genomic_DNA.
DR RefSeq; XP_636832.1; XM_631740.1.
DR AlphaFoldDB; Q54JA4; -.
DR IntAct; Q54JA4; 1.
DR MINT; Q54JA4; -.
DR STRING; 44689.DDB0233527; -.
DR PaxDb; Q54JA4; -.
DR PRIDE; Q54JA4; -.
DR EnsemblProtists; EAL63329; EAL63329; DDB_G0288197.
DR GeneID; 8626501; -.
DR KEGG; ddi:DDB_G0288197; -.
DR dictyBase; DDB_G0288197; sibD.
DR HOGENOM; CLU_234725_0_0_1; -.
DR InParanoid; Q54JA4; -.
DR PhylomeDB; Q54JA4; -.
DR PRO; PR:Q54JA4; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR InterPro; IPR000742; EGF-like_dom.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
PE 1: Evidence at protein level;
KW Cell adhesion; Coiled coil; Disulfide bond; EGF-like domain; Glycoprotein;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..1957
FT /note="Integrin beta-like protein D"
FT /id="PRO_0000312334"
FT TOPO_DOM 22..1890
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1891..1911
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1912..1957
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 421..458
FT /note="EGF-like"
FT DOMAIN 514..705
FT /note="VWFA"
FT COILED 520..547
FT /evidence="ECO:0000255"
FT CARBOHYD 112
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 255
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 298
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 313
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 324
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 406
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 588
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 654
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 661
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 750
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 991
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1266
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1368
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1528
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1591
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1632
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1646
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1670
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1680
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1756
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1763
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1775
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1827
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1867
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1888
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 431..446
FT /evidence="ECO:0000250"
FT DISULFID 448..457
FT /evidence="ECO:0000250"
SQ SEQUENCE 1957 AA; 214290 MW; 9A0F61C1C9449757 CRC64;
MFSFVVKLLF FIYFLITFSN ASHIRFGTFK WQPTTQYNEI QFTLDLGFRT SAWFSNLPQK
NDFIKISFNF GDNVVSTYQL ILTTVDSKDD WFTGTSVFSH TYPTLEVGKT ANYTAFYSLC
CRISTLLNEK DGDFTIKSLV QIDNSNSLDK INWSPVSGMV PIYPVTYGRN NNFNIPASDQ
HLRPGEYSNL VFTFGEAKPD GMTLDKNTGM VYFMPSSVGL YCAKVIITDK NGAYITLDFI
LQSEIQNGFC HHQCNNSGEI CTKNSDCINC GNLVYNKTQD ACLSTKPIFI YPPTPKPNQT
QTFVIGEQNE GFNVSCTTDA IGLNTTIQPV GFPIGFITKI LEIGPKSTIN LLWFPTSFQD
YGTYVKYIVC TDSLIKITTS IEIIIKKPDC SNGGFRDKGI CVCPKNFTSE SDCLDCSKGY
YGEKCIAVPL CVNGVSNSGI LGDGKCYCNN GWIGDDCSIS NSQSCGSLKS GVVSSSIMEQ
SYINPVGIQV YLANNQKYQI QVNIKIPEKN KLIDVYFLID INQNTQNEFN NILSQLNDAK
TKILELSPES VSFGLGIIDE NGLFADLAKI PSDSIVTSLE NKKWSGYNHT ITGKSLSAAT
KAAKTPLGWR TNAFKSMIII PRTDLPLSPI QTEIDEFKNA FIEKSIAPVV IGINVSLSNW
NSTLYQCGFG AYKLSSDAQG WKNFVKTAFK ETSSSVLGNG VLQNIIFKVN DNSGGLAFLK
SIPENLPIDA DIEVVKTLSG LSLSLPINYN SSINPSLRVC TIGYGCIDIK TNYNHPPTPN
PFGISCNQNS DAIFQLEGSD PDRNILTFKF TSFLSSTEGL IKTSKGIDVS TQKDELYAGS
EKFTFSPYKN YLKSLYISFI ADDGCLTSDS SAKVSFSINK VNQPPECSSA IVISEFEKTV
DFSFTATDFE DDDQLLILNA QFIVSSELAS LEQYGQLTYI GAKVTIDTII KKSVKILFKQ
TKNPLNLLVP LTFKSKDSSG LFSNLCTQTI NITHTNEAPI SNDGTSVTIP RSIGNPLSLL
STDIDSKSAI FTIKKVNAGK TGTFYSCTDN SCSCVAGSND RIDITDNTKY SQIQYAKNQA
SLPICFTNSE PSAVPNYAFI SFTSTDDEGL ESNLATVIVN IVGYRTNVAP VVNKIQDYSV
YQDYLDSDAH VVTGTDADID DYNPQNANNL IAIITNPPSN GILVTVQNGS SIAIQGNAPF
THYYRPNPGY AGTDSYSYQV IDTFNAKSSI ESTTITIKPI NHKPNVLIDV YKFTSESGDG
VIETLNTSDQ DGDNVICSVI SLPKQILMYD DKGVQIKSVP MVLPNNAYSF KLLDPSIITP
TPFSNVLSTF SINCVDDSEK TTPKGVLSTG DVIGNVQYYY INTPPKTNIS SVKLSQDSFI
AFSFEGSDIE SNEKLLKVLL YSLPINGKLS KSIDSNVVLT KELIGGDNTF GLDELTYTPL
PGQSNWDTVD HLGPLDRISY SIVDPQGLLS PSSTISFQVR SRNPPIYLGD SDISVLQNTR
FPLTIEGELG GGGLSVSIRV LSFSGRGNLS ISHSMGKEGF FDKLITEYPS QQLGSTSYNF
AYNPPRNQFG SNFDQIQFIL FDNDIISKIY NITVNVIHVN QPPATELISY RILNQFEKEI
QIDGSTINMN VNDSVLIKIY GSDIDNQTVP LVALVSNLPL RGLIYSFDDN SSDYLGREIN
HTSQLIPLNE DGYWYVIFIP TKGTTGDNYA RVPFNVIDEK GVVSQTSTVI INVNSVNLQP
KIYIGSNSNT FVGKVNLTIS ITNITLDDPD SVNNNISLIV SIVDDNDGDE VLPLSIIKLS
FTQATPKCNP NLNLALITCI GSKKSLNASI STISVIGSIS GKYRLKLFID DLGYSAPSTV
RAESHLNATG YVNIIINDPI ATTQNTDNKT VLSGAIAGAS AGAALLVIGL WKMIKRSSPP
TDTFFDEGAF MGDVSSSPIY EKSETSYVSR IYEGADD
