SIBE_DICDI
ID SIBE_DICDI Reviewed; 1946 AA.
AC Q54JA3;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Integrin beta-like protein E;
DE Flags: Precursor;
GN Name=sibE; ORFNames=DDB_G0288239;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP IDENTIFICATION, AND INTERACTION WITH TALA.
RX PubMed=16699495; DOI=10.1038/sj.embor.7400701;
RA Cornillon S., Gebbie L., Benghezal M., Nair P., Keller S.,
RA Wehrle-Haller B., Charette S.J., Brueckert F., Letourneur F., Cosson P.;
RT "An adhesion molecule in free-living Dictyostelium amoebae with integrin
RT beta features.";
RL EMBO Rep. 7:617-621(2006).
CC -!- FUNCTION: Implicated in cellular adhesion. {ECO:0000305}.
CC -!- SUBUNIT: Interacts with talA/talin. {ECO:0000269|PubMed:16699495}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SIB family. {ECO:0000305}.
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DR EMBL; AAFI02000109; EAL63350.1; -; Genomic_DNA.
DR RefSeq; XP_636833.1; XM_631741.1.
DR AlphaFoldDB; Q54JA3; -.
DR IntAct; Q54JA3; 1.
DR MINT; Q54JA3; -.
DR STRING; 44689.DDB0233519; -.
DR PaxDb; Q54JA3; -.
DR EnsemblProtists; EAL63350; EAL63350; DDB_G0288239.
DR GeneID; 8626502; -.
DR KEGG; ddi:DDB_G0288239; -.
DR dictyBase; DDB_G0288239; sibE.
DR HOGENOM; CLU_234725_0_0_1; -.
DR InParanoid; Q54JA3; -.
DR PhylomeDB; Q54JA3; -.
DR PRO; PR:Q54JA3; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 1: Evidence at protein level;
KW Cell adhesion; Disulfide bond; EGF-like domain; Glycoprotein; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..1946
FT /note="Integrin beta-like protein E"
FT /id="PRO_0000312335"
FT TOPO_DOM 23..1875
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1876..1896
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1897..1946
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 423..460
FT /note="EGF-like"
FT DOMAIN 514..699
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT CARBOHYD 107
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 203
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 705
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 860
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1043
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1113
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1177
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1374
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1401
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1513
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1611
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1620
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1662
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1671
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1737
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1743
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1762
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1812
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1852
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1873
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 433..448
FT /evidence="ECO:0000250"
FT DISULFID 450..459
FT /evidence="ECO:0000250"
SQ SEQUENCE 1946 AA; 206822 MW; CAA1A41B36BBA0BE CRC64;
MNNLFKFLFV LLAIFCPPIS DLVVSHGVPQ QHITIIKFTT NFAFRTTFYK TSSSSIVIGE
KITLGTLTFG DGSSTSVRAS VTSFDTKNDW FFGQFIFTKT YTALTPNNSK QYLAMFTSCC
RISTLLNNKD ADWNITSSVY LDNKNWPSVN HSPVSGMLPI VQVIANKNNN FRVIASDPNV
DDKLSFSFST VYPMTQPSGM KINSTGHVFF LPTSVGLYST QIYITDDAVP PAYAVVDFIL
ESITEPGKCD PSCSNGGATC NGNSECKNCA NAGSTTSNTC STTNYPPYFV SPTPQDNQLI
PFTVGQPNSI TLSCKSDYTT RTVGIQAANV PAGAAIAEGT SSQGTVKNIL SWTPVAANVG
VYVTSIFCYD SNGLTSSSRS FTIFIAKPEC GNGHKDPSTG KCKCDGDKWD PTSNCFDCST
GYYGQNCDPT PPCDKGIPNE GILGDGKCMC INGYSGDKCD VPLSQSCKDL KNSILLSTSV
PSFFVNPTKV QLYIESDFAL TTSLNIPQKL TKIDVFVLVD VNVASSTLFG VVQSSISTFV
TEVSKSICET TQFGIGYFSD ASSSGFNFAP GSIIGSNIVN TINGYAVSSY TSTSSGNSLL
GATNAASNSN GWNSGSFKAI VVLTDKDHSS NSAAITNFVN TYISNSIAPV VVGFGASSIP
NWNSAISTAD FGYSTVSAAT SIDISAKAVA GLKSVLSNVV YKTDNTTNGA SFVKSTPSDV
AVSSTADTVK TVSGLVLTKP SATSIVSPVA SVSAIGFGQT DFSINYNRPP TPTGTAFSVN
QNSFATFKLT GTDPDFNILT FAFTTFLTSD VGVITDSNNK DVSTQKSKYY DSTETFTFTP
AINYLLPISV SFVANDGCLN STTSATVSIT INKVNQLPTC QQKTISPTLN VANKFVLSAS
DFEDATPFIQ FTSPTDLTAY GTLTFGGVAV TSTSKIPTSS EITFTQTVNP TNAIDVPVSF
QAVDSVGAIS TSTCTLTVKL VHTNIKPVSS STSPISVIPR GSVSLTLVST DSDSTSAKFT
IKSVNKGAKG DFYTCSTNDC TCNSTQTNIY TSISTTTTYT SISYTNKVAN KLICFTNGEP
SAISNYASIS FTSTDNQGLE SDSVNVVVNI VGNRTNVAPV VTKIQGYSVY QDYLDSDAHV
VTGTDADIDD YNPPNVNNLI AIITTPPSNG ILVTLQNGSI AATQGKAPFT HYYRPNPGFK
GTDSYSYQVV DTFKAGSSIE STTVTVNPIN HKPSVVVSSY SFTSQSGDGE TQDLVTSDPD
GDSVICSVVS IPSQIGMYDS DGNLIESVPT VLSGTSYSFK LLDPSKITPT PFTSVSSSFA
VKCTDVTTKT IPFGTLSTGV VTANVQYTYI NTPPTTQGGT VQLDQDTVKV FTFNGSDIET
PKDDIKVKIL SLPINGQLLI NATGVALTTT NIASETYNLN ALSYKPNAGL SNWNTIDQQS
PLDSISYTVI DQQGLTSDSD IVYFSVRPRN PPVYTGARVI DVLQNTRYPL TITSRIGGGG
SEVNIQVIGF TNNGTLSIAH NMGSEGTMDS EITSYPNQQS GSTSYNYAYM PPRNKYGNDF
DFIYFKLFDG DLYSELYTVT VNVIHVNQPP TIELVSYKIL DGVSSEVLFE NTSLINMNIN
TTVLIKYSGN DIDVDQVTPL ISMIPNFPLR GSLYAYNPTA SNSSGAPITR NSSNVEQNAD
GFYYVVFVPS KKTSGESYAR ITFIMTDNGG LNSPIVGVLI NVNTVNIAPF VIIGNKNYTT
QTNLTASVMG VQFDDPDSTT NNVSIVVSIV GQKDDKVASL KDIKLSFTQS PMCEYHQTLA
SITCIGPKKP LNSSIVSISV IASTAGDYRL KLFVDDLGYN APSAIRAQSH LNATGYVDVK
VNAPEATTQT TNNKTVLTGA IAGAAAGTAL IAAAAWKLLR KAAPPTDTFF SEAAFLGDGV
NANPLYEQSA SAAENPLYQS ASDNTD
