ID   SICA_SALDU              Reviewed;         165 AA.
AC   P69064; P40703; Q57260;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Chaperone protein SicA;
DE   AltName: Full=Salmonella invasin chaperone;
GN   Name=sicA;
OS   Salmonella dublin.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=98360;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=2229;
RA   Mullan P.B., Gautier A.V., Wood M.W., Edwards M.H., Jones B.V.,
RA   Galyov E.E.;
RT   "Sip invasins of Salmonella dublin are involved in macrophage cytotoxicity
RT   and mouse virulence.";
RL   Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Type III secretion-associated chaperone required for SipB and
CC       SipC stabilization. Prevents premature association of SipB with SipC,
CC       which may lead to their targeting for degradation. Along with InvF,
CC       required for transcription activation of sigDE (sopB pipC),
CC       sicAsipBCDA, and sopE (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Dimer or higher-order oligomers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LcrH/SycD chaperone family. {ECO:0000305}.
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DR   EMBL; U66877; AAB06794.1; -; Genomic_DNA.
DR   RefSeq; WP_000386309.1; NZ_VDCP01000001.1.
DR   AlphaFoldDB; P69064; -.
DR   SMR; P69064; -.
DR   GeneID; 66757211; -.
DR   PATRIC; fig|98360.39.peg.2685; -.
DR   OMA; DKRFWMG; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR005415; T3SS_Ca_resp_chp_LcrH/SycD.
DR   InterPro; IPR016379; T3SS_Ca_resp_chp_LcrH/SycD_sub.
DR   InterPro; IPR011716; TPR-3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF07720; TPR_3; 2.
DR   PIRSF; PIRSF003165; Chaperone_SicA; 1.
DR   PRINTS; PR01595; SYCDCHAPRONE.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   TIGRFAMs; TIGR02552; LcrH_SycD; 1.
PE   3: Inferred from homology;
KW   Activator; Chaperone; Cytoplasm; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..165
FT                   /note="Chaperone protein SicA"
FT                   /id="PRO_0000206487"
SQ   SEQUENCE   165 AA;  19221 MW;  A6493800BCF19561 CRC64;
     MDYQNNVSEE RVAEMIWDAV SEGATLKDVH GIPQDMMDGL YAHAYEFYNQ GRLDEAETFF
     RFLCIYDFYN PDYTMGLAAV CQLKKQFQKA CDLYAVAFTL LKNDYRPVFF TGQCQLLMRK
     AAKARQCFEL VNERTEDESL RAKALVYLEA LKTAETEQHS EQEKE