ID   SICA_SALTI              Reviewed;         165 AA.
AC   P69065; P40703; Q57260;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Chaperone protein SicA;
DE   AltName: Full=Salmonella invasin chaperone;
GN   Name=sicA; Synonyms=spaT; OrderedLocusNames=STY3009, t2788;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=8801431; DOI=10.1111/j.1365-2958.1995.mmi_17040781.x;
RA   Hermant D., Menard R., Arricau N., Parsot C., Popoff M.Y.;
RT   "Functional conservation of the Salmonella and Shigella effectors of entry
RT   into epithelial cells.";
RL   Mol. Microbiol. 17:781-789(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Type III secretion-associated chaperone required for SipB and
CC       SipC stabilization. Prevents premature association of SipB with SipC,
CC       which may lead to their targeting for degradation. Along with InvF,
CC       required for transcription activation of sigDE (sopB pipC),
CC       sicAsipBCDA, and sopE (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Dimer or higher-order oligomers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LcrH/SycD chaperone family. {ECO:0000305}.
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DR   EMBL; X82670; CAA57987.1; -; Genomic_DNA.
DR   EMBL; AL513382; CAD05993.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO70349.1; -; Genomic_DNA.
DR   PIR; AB0851; AB0851.
DR   PIR; S70217; S70217.
DR   RefSeq; NP_457280.1; NC_003198.1.
DR   RefSeq; WP_000386309.1; NZ_WSUR01000005.1.
DR   AlphaFoldDB; P69065; -.
DR   SMR; P69065; -.
DR   STRING; 220341.16503964; -.
DR   EnsemblBacteria; AAO70349; AAO70349; t2788.
DR   GeneID; 66757211; -.
DR   KEGG; stt:t2788; -.
DR   KEGG; sty:STY3009; -.
DR   PATRIC; fig|220341.7.peg.3063; -.
DR   eggNOG; COG0457; Bacteria.
DR   HOGENOM; CLU_093829_1_0_6; -.
DR   OMA; DKRFWMG; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR005415; T3SS_Ca_resp_chp_LcrH/SycD.
DR   InterPro; IPR016379; T3SS_Ca_resp_chp_LcrH/SycD_sub.
DR   InterPro; IPR011716; TPR-3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF07720; TPR_3; 2.
DR   PIRSF; PIRSF003165; Chaperone_SicA; 1.
DR   PRINTS; PR01595; SYCDCHAPRONE.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   TIGRFAMs; TIGR02552; LcrH_SycD; 1.
PE   3: Inferred from homology;
KW   Activator; Chaperone; Cytoplasm; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..165
FT                   /note="Chaperone protein SicA"
FT                   /id="PRO_0000206488"
SQ   SEQUENCE   165 AA;  19221 MW;  A6493800BCF19561 CRC64;
     MDYQNNVSEE RVAEMIWDAV SEGATLKDVH GIPQDMMDGL YAHAYEFYNQ GRLDEAETFF
     RFLCIYDFYN PDYTMGLAAV CQLKKQFQKA CDLYAVAFTL LKNDYRPVFF TGQCQLLMRK
     AAKARQCFEL VNERTEDESL RAKALVYLEA LKTAETEQHS EQEKE