BH075_ARATH
ID BH075_ARATH Reviewed; 223 AA.
AC A4D998; A0ME91; Q9FRI2;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Transcription factor bHLH75;
DE AltName: Full=Basic helix-loop-helix protein 75;
DE Short=AtbHLH75;
DE Short=bHLH 75;
DE AltName: Full=Transcription factor EN 78;
DE AltName: Full=bHLH transcription factor bHLH075;
GN Name=BHLH75; Synonyms=EN78; OrderedLocusNames=At1g25330; ORFNames=F4F7.28;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 131-223, TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [7]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [8]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed in leaves, stems, and flowers.
CC {ECO:0000269|PubMed:12679534}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG28811.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=ABK28414.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC079374; AAG28811.2; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE30607.1; -; Genomic_DNA.
DR EMBL; DQ446289; ABE65654.1; -; mRNA.
DR EMBL; DQ652859; ABK28414.1; ALT_SEQ; mRNA.
DR EMBL; AK175757; BAD43520.1; -; mRNA.
DR EMBL; AY088885; AAM67191.1; -; mRNA.
DR EMBL; AF488607; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; B86383; B86383.
DR PIR; D86381; D86381.
DR RefSeq; NP_564229.1; NM_102343.4.
DR AlphaFoldDB; A4D998; -.
DR SMR; A4D998; -.
DR BioGRID; 24354; 2.
DR IntAct; A4D998; 3.
DR MINT; A4D998; -.
DR STRING; 3702.AT1G25330.1; -.
DR PaxDb; A4D998; -.
DR PRIDE; A4D998; -.
DR ProteomicsDB; 241215; -.
DR EnsemblPlants; AT1G25330.1; AT1G25330.1; AT1G25330.
DR GeneID; 839117; -.
DR Gramene; AT1G25330.1; AT1G25330.1; AT1G25330.
DR KEGG; ath:AT1G25330; -.
DR Araport; AT1G25330; -.
DR TAIR; locus:2032990; AT1G25330.
DR eggNOG; ENOG502RY3S; Eukaryota.
DR HOGENOM; CLU_1241614_0_0_1; -.
DR InParanoid; A4D998; -.
DR OMA; HINQTQE; -.
DR OrthoDB; 1206509at2759; -.
DR PhylomeDB; A4D998; -.
DR PRO; PR:A4D998; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; A4D998; baseline and differential.
DR Genevisible; A4D998; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:2000488; P:positive regulation of brassinosteroid biosynthetic process; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:TAIR.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR024097; bHLH_ZIP_TF.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR12565; PTHR12565; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..223
FT /note="Transcription factor bHLH75"
FT /id="PRO_0000358767"
FT DOMAIN 110..160
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 58..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 180
FT /note="L -> P (in Ref. 6; AF488607)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 223 AA; 25209 MW; FDB154E92AFC1181 CRC64;
MARFEPYNYN NGHDPFFAHI NQNPELINLD LPASTPSSFM LFSNGALVDA NHNNSHFFPN
LLHGNTRRKG NKEESGSKRR RKRSEEEEAM NGDETQKPKD VVHVRAKRGQ ATDSHSLAER
VRREKINERL KCLQDLVPGC YKAMGMAVML DVIIDYVRSL QNQIEFLSMK LSAASACYDL
NSLDIEPTDI FQGGNIHSAA EMERILRESV GTQPPNFSST LPF
