SICK_DROME
ID SICK_DROME Reviewed; 2197 AA.
AC Q9VIQ9; Q7KT30; Q7KT31;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 3.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Protein sickie;
GN Name=sick; Synonyms=sickie; ORFNames=CG34343;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP FUNCTION.
RX PubMed=15221030; DOI=10.1371/journal.pbio.0020203;
RA Foley E., O'Farrell P.H.;
RT "Functional dissection of an innate immune response by a genome-wide RNAi
RT screen.";
RL PLoS Biol. 2:1091-1106(2004).
CC -!- FUNCTION: Required for the immune deficiency pathway, which mediates
CC responses to Gram-negative bacterial infection. Favors Rel activation
CC and nuclear translocation. {ECO:0000269|PubMed:15221030}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=B {ECO:0000312|FlyBase:FBgn0263873};
CC IsoId=Q9VIQ9-1; Sequence=Displayed;
CC Name=D {ECO:0000312|FlyBase:FBgn0263873};
CC IsoId=Q9VIQ9-3; Sequence=VSP_030259;
CC Name=N {ECO:0000312|FlyBase:FBgn0263873};
CC IsoId=Q9VIQ9-4; Sequence=VSP_058138;
CC -!- SIMILARITY: Belongs to the Nav/unc-53 family. {ECO:0000305}.
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DR EMBL; AE014134; AAF53856.3; -; Genomic_DNA.
DR EMBL; AE014134; AAS64722.2; -; Genomic_DNA.
DR EMBL; AE014134; AAS64723.2; -; Genomic_DNA.
DR RefSeq; NP_001097183.1; NM_001103713.4. [Q9VIQ9-3]
DR RefSeq; NP_001260605.1; NM_001273676.1. [Q9VIQ9-3]
DR RefSeq; NP_995729.2; NM_206007.5. [Q9VIQ9-1]
DR RefSeq; NP_995730.2; NM_206008.4. [Q9VIQ9-4]
DR AlphaFoldDB; Q9VIQ9; -.
DR BioGRID; 61249; 12.
DR IntAct; Q9VIQ9; 4.
DR STRING; 7227.FBpp0302887; -.
DR PaxDb; Q9VIQ9; -.
DR PRIDE; Q9VIQ9; -.
DR EnsemblMetazoa; FBtr0329840; FBpp0302881; FBgn0263873. [Q9VIQ9-3]
DR EnsemblMetazoa; FBtr0329842; FBpp0302883; FBgn0263873. [Q9VIQ9-1]
DR EnsemblMetazoa; FBtr0329843; FBpp0302884; FBgn0263873. [Q9VIQ9-3]
DR EnsemblMetazoa; FBtr0344856; FBpp0311171; FBgn0263873. [Q9VIQ9-4]
DR GeneID; 35277; -.
DR KEGG; dme:Dmel_CG43720; -.
DR UCSC; CG34343-RB; d. melanogaster. [Q9VIQ9-1]
DR CTD; 35277; -.
DR FlyBase; FBgn0263873; sick.
DR VEuPathDB; VectorBase:FBgn0263873; -.
DR eggNOG; ENOG502QPT3; Eukaryota.
DR InParanoid; Q9VIQ9; -.
DR OMA; NHISAVH; -.
DR PhylomeDB; Q9VIQ9; -.
DR BioGRID-ORCS; 35277; 0 hits in 3 CRISPR screens.
DR ChiTaRS; sick; fly.
DR GenomeRNAi; 35277; -.
DR PRO; PR:Q9VIQ9; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0263873; Expressed in embryonic dorsal epidermis (Drosophila) and 43 other tissues.
DR ExpressionAtlas; Q9VIQ9; baseline and differential.
DR Genevisible; Q9VIQ9; DM.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0007015; P:actin filament organization; IMP:FlyBase.
DR GO; GO:0007409; P:axonogenesis; IMP:FlyBase.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR GO; GO:0061059; P:positive regulation of peptidoglycan recognition protein signaling pathway; IMP:FlyBase.
DR Gene3D; 1.10.418.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR039041; Nav/unc-53.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12784; PTHR12784; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00307; CH; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Coiled coil; Immunity; Innate immunity;
KW Reference proteome.
FT CHAIN 1..2197
FT /note="Protein sickie"
FT /id="PRO_0000286980"
FT DOMAIN 21..129
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT REGION 165..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 788..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1094..1119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1202..1223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1373..1415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1455..1511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1600..1633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1648..1690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2172..2197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1262..1342
FT /evidence="ECO:0000255"
FT COILED 1556..1591
FT /evidence="ECO:0000255"
FT COMPBIAS 168..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..426
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1497..1511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1600..1625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1651..1667
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..25
FT /note="MLARCVSYQGSCDNINGILTRDYAE -> MYGQ (in isoform N)"
FT /evidence="ECO:0000305"
FT /id="VSP_058138"
FT VAR_SEQ 2..207
FT /note="LARCVSYQGSCDNINGILTRDYAEIYTDWANYYLERAKSKRKVTDLSADCRD
FT GLLLAEVIEAVTSFKVPDLVKKPKNQQQMFDNVNSCLHVLRSQSVGGLENITTNDICAG
FT RLKAVLALFFALSRFKQQAKQTKSIGVGCGGGVGGSSSTLTGSGSVLGIGIGGLRTPGS
FT SLNQDKNQQEQQQQQQQQQTPQQLAQSLENGNEMVN -> GNASSSSANGGKSSRKCRS
FT LPNSPDVR (in isoform D)"
FT /evidence="ECO:0000305"
FT /id="VSP_030259"
SQ SEQUENCE 2197 AA; 234498 MW; B45D37BE3F9D3F6E CRC64;
MLARCVSYQG SCDNINGILT RDYAEIYTDW ANYYLERAKS KRKVTDLSAD CRDGLLLAEV
IEAVTSFKVP DLVKKPKNQQ QMFDNVNSCL HVLRSQSVGG LENITTNDIC AGRLKAVLAL
FFALSRFKQQ AKQTKSIGVG CGGGVGGSSS TLTGSGSVLG IGIGGLRTPG SSLNQDKNQQ
EQQQQQQQQQ TPQQLAQSLE NGNEMVNRQI APAYAKVNGG TAIPLPATVM VQRRCPPDKV
RPLPPTPNHT PSIPGLGKSG SDFNTSRPNS PPTSNHTIQS LKSGNNNSLR PPSIKSGIPS
PSSPQTAPQK HSMLDKLKLF NKEKQQNAVN AASVASKTQI QSKRTSSSSG FSSARSERSD
SSLSLNDGHG SQLKPPSISV SSQKPQPKTK QSKLLAAQQK KEQANKATKL DKKEKSPARS
LNKEESGNES RSSTMGRTGK SSLVRAVGGV EKNTPKTSSK SSLHSKSDSK SSLKAPQLLQ
SPSSGGLPKP IAAIKGTSKL PSLGGGAGHL PAAESQQNQQ LLKRETSDIS SNISQPPPAE
PPISTHAHIH QNQTPPPPYY ANSQPTSHIS SHGFLSEPST PQHSSGIYGS SRLPPPKSAL
SAPRKLEYNA GPHILSSPTH HQRQGLPRPL VNSAPNTPTA SPNKFHTIPS KIVGTIYESK
EEQLLPAPPP ASGGSSILPM RPLLRGYNSH VTLPTRGARG GHHPHQSYLD FCESDIGQGY
CSDGDALRVG SSPGGSRFHD IDNGYLSEGS SGLNGPSSSA GGISPGKHFL SMMRARTQLP
TTIEERIRNS RGSLDSIGTA ANGSSAASQA SSSGGSTTTH AQNNNNNNNN NSGGGAKMDG
SPHHRPGSRN GRDNWSKMPE PLNGQKVEKS DKSSPSRRSM GGGGSGSSSK QGSPSSSSRT
KGVPPSFGYV KRANGSIAST AEQQNIAMMM AAGGAGANGL PCGRTAHVSA VPRTASGRKV
AGGTQTLPND MNKLPPNTQH RSFSLTGPTA TQLSQSIRER LATGSHSLPK PGSDLHVFQH
RISNRGGTRH DGSLSDTQTY AEVKPEYSSY AMWLKHSNTA GSRLSDGESV EQLQIGSPAL
TRHGHKMIHN RSGGPGQMAG QMSGNESPYV QSPRMNRSNS IRSTKSEKMY PSMMSRAGEV
EIEPYYCLPV GTNGVLTAQM AAAMAAQSQA AQGNPGVGVN VGGVAWSQPT SPTPLTRGPF
NTAAGASVLS PTHGTTSAAG LVGPGGGAGG GAMVGHRLTY PKKNDEVHGS AASLLSGGSS
LYGNAEERQA HEIRRLKREL QDARDQVLSL SSQLSTNAHV VTAFEQSLSN MTNRLHQLTA
TAERKDGELT DMRQTIELLR KQSIQAGLTT AHMQSMGVQT QGQGQVQGQA LGQALGQPGS
DQKPPNSGSQ RAINANNGSM PLGMQRQHST DSMCSLNSIS SGCSAAQDKN KANKKKGWLR
SSFTKAFSRN AKISKTSRHV GHHHHHNHSQ QELASGKLPL HNGHGEPLGL ASLATQPAPP
LPNSKQSSPA KTVTLIDNAK PIDAIDQEDQ HVVEDLKKQL REKDLVLTDI RLEALSSASQ
LESLKEMMNK MRAEMMSLKH NNERLQKLVT TRSLAGSEAS LGQAISPNGS VAGSSEVSRR
YSLADSNSRP PMELPARLSE ELELEEDCLP PAPAPEQPPP PAPNGVSVAP LSPSTHVDLT
PPPPALEAAP MASPVHMASA TEELADVCDG KKIAIACYLG QPEAFAKYCE ELQELDGFYA
NGHEADSQSQ SERKSNYTSA SCNEFVIACT YISGKTTWQN LDYVVRKTFK DYVARIDPGT
NLGLNTDSIT SYHLGEAKRG PEMGFPELLP CGYIVGSVRT LYICLQGVGS LAFDSLIPRS
IVHRYISLLT EHRRLILCGP SGTGKSYLAR RLAEFLVARS ARGNPSEAIA TFNVDHKSSK
DLRQYLGHIA EQAAIANGVS ELPSVIILDN LHHASALGDV FSCLLSAGPA NKLPCIIGTM
SQATCNTTNL QLHHNFRWVL TANHMEPVKG FLGRFLRRRL FQLELQTQHP QPELAAVLAW
LPSVWQHINR FLEVHSSSDV TIGPRLFLAC PMDLKDSQVW FTDIWNYHLS PYLVEAVREG
VQLYGRRGGA WNDPSAFIRN SYPWPYGPDS VPPLRQINAE DVGLEGVALT NGDQQDPLLN
MLMRLQEAAN YSEAQDQESD CASLDSNVTP ESSAGAE
