ID   SID2_USTMA              Reviewed;        4114 AA.
AC   O43103; A0A0D1C9V1; Q4P3Z8;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 2.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Ferrichrome siderophore peptide synthetase;
DE            EC=6.-.-.-;
GN   Name=SID2; ORFNames=UMAG_10189;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA   Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA   Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA   Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA   Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA   Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA   Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA   Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA   Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA   Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA   Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT   maydis.";
RL   Nature 444:97-101(2006).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-4082.
RX   PubMed=11395469; DOI=10.1128/jb.183.13.4040-4051.2001;
RA   Yuan W.M., Gentil G.D., Budde A.D., Leong S.A.;
RT   "Characterization of the Ustilago maydis sid2 gene, encoding a multidomain
RT   peptide synthetase in the ferrichrome biosynthetic gene cluster.";
RL   J. Bacteriol. 183:4040-4051(2001).
CC   -!- FUNCTION: Multidomain peptide synthetase involved in ferrichrome
CC       biosynthesis.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000250};
CC       Note=Binds 4 phosphopantetheines covalently. {ECO:0000250};
CC   -!- PATHWAY: Siderophore biosynthesis; ferrichrome biosynthesis.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB93493.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; U62738; AAB93493.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; CM003143; KIS70092.1; -; Genomic_DNA.
DR   PIR; T52486; T52486.
DR   RefSeq; XP_011388352.1; XM_011390050.1.
DR   SMR; O43103; -.
DR   STRING; 5270.UM05165P0; -.
DR   PRIDE; O43103; -.
DR   EnsemblFungi; KIS70092; KIS70092; UMAG_10189.
DR   GeneID; 23566253; -.
DR   KEGG; uma:UMAG_10189; -.
DR   VEuPathDB; FungiDB:UMAG_10189; -.
DR   eggNOG; KOG1176; Eukaryota.
DR   eggNOG; KOG1178; Eukaryota.
DR   InParanoid; O43103; -.
DR   OrthoDB; 4243at2759; -.
DR   BioCyc; MetaCyc:MON-18969; -.
DR   UniPathway; UPA00783; -.
DR   Proteomes; UP000000561; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031177; F:phosphopantetheine binding; IBA:GO_Central.
DR   GO; GO:0043041; P:amino acid activation for nonribosomal peptide biosynthetic process; IBA:GO_Central.
DR   GO; GO:0010106; P:cellular response to iron ion starvation; IBA:GO_Central.
DR   GO; GO:0031169; P:ferrichrome biosynthetic process; IBA:GO_Central.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IBA:GO_Central.
DR   Gene3D; 1.10.1200.10; -; 4.
DR   Gene3D; 3.30.300.30; -; 3.
DR   Gene3D; 3.30.559.10; -; 4.
DR   Gene3D; 3.40.50.12780; -; 3.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   Pfam; PF00501; AMP-binding; 3.
DR   Pfam; PF00668; Condensation; 4.
DR   Pfam; PF00550; PP-binding; 4.
DR   SMART; SM00823; PKS_PP; 4.
DR   SUPFAM; SSF47336; SSF47336; 4.
DR   PROSITE; PS00455; AMP_BINDING; 3.
DR   PROSITE; PS50075; CARRIER; 4.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE   3: Inferred from homology;
KW   Ligase; Multifunctional enzyme; Phosphopantetheine; Phosphoprotein;
KW   Reference proteome; Repeat.
FT   CHAIN           1..4114
FT                   /note="Ferrichrome siderophore peptide synthetase"
FT                   /id="PRO_0000193098"
FT   DOMAIN          797..874
FT                   /note="Carrier 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   DOMAIN          1947..2021
FT                   /note="Carrier 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   DOMAIN          3020..3093
FT                   /note="Carrier 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   DOMAIN          3574..3650
FT                   /note="Carrier 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   REGION          4040..4061
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         835
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         1982
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         3054
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         3611
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
SQ   SEQUENCE   4114 AA;  451160 MW;  AC2CD5F26F3641F1 CRC64;
     MSVSKNAHAP FPDVTGLRTS GPDFSRVGPQ CKLLRVQQSL HLDARAASSF SGQDLHLALL
     SAWCVILFHY GSHEATNIEV LHTSQHGHET LVELDFAEQR ELVPFTPSQL AAFVHQARQQ
     QLPAKDLDHG YAAFYQPSHT NEPSPHFQQL QLSSRPDISL ALSYHLQGSA QLVLEMKAAP
     SVHSHQSAQL QLRQVAALLE SYHSDTQQHA LSVERFDWKL RASDNPNYQH LPDPNHIQDR
     HADRLETEFE YFAATTPDAL ALDFRFDLQD LKSTKWSYAE MNQRAEKVKH LLWSHGVGSA
     SSDPQADHIV ALYLEKSPET YLSFIGVLKA GAAWCPIDTD WPASRRQALL AKSNAKIVLT
     HDDKISEQLR HDLESQLVKD KGEITAIRLD QLDAELSQVQ VVPPANANRS IQQLAYMIWT
     SGTTGLPKGV GIQHLAIIQA MRALRIYIPY GKDKIGTDQI RYLQYSAYNF DLSIMDCFYT
     WGLGGTICSC PRGVLLQDLV EVGNSLQPTH TLLTPAVMAM TERHRVPSLK VVISGGEKLS
     QVVADEWSKD CCLLNLYGPA EATLIAMNRR VPFGDRVKAP NIGVALPTVS CHALDKYDQI
     VIKGAVGELV LGGPQLARGY VGDPVKTADK FFPHPQLGRV YRTGDLVRQL DNQEFEYLGR
     IDDQVKINGI RIELLEINAA IKNSHDKIKD SETMAFSKKD NESEQQIINF SALPGGEPGQ
     LLRTDQDAIA VARELQANAK DSLPSYMVPN LFVILSHFPR TSSAKIDRVA LKNVLASFDQ
     LDWENKLANE GDDDQVDPAT AQAEACLRKW LAKLCNVDAS KIGRKTPFTS VGLDSIRAMM
     FSKRVSEEGF AVSVLDVARF PTLKSLGEHL QSSGASSEER AKRAASFLAD FDAAFRPVVS
     SWVKQRKADA SAIQSILPCT PLQEGMLAES QRDSSSYRIQ RQYRLASDCD QARLSKALIE
     TVAHFDSLRT SFADVGSLDV GLHQREWPFQ PHFLQIVWKS FTPLIEQLDV DDGSDAEQAI
     LSAAKTKLDL DPFGTSPPVA FLFVKQALSR SLVVVAHHST YDARSLGIFE DHVEAVYNRQ
     KPPTSLQFST ALAQILPIDQ TEAQRHADVW QKALSNYPRG EYASFPTLSL TRPSEADADQ
     ASLHQSRYLE ANINWAKIES ACRELGVSAR PLVQTAWALV LSAFTESQHL ILGDSVSGRT
     LSAELDLAYG PVLSTVPVPF MLRPEQKLGN LIKQMDDFQT SIMEAQHTDL GAIRRMLQVP
     PRESLFHSVF VLEPAPEQPE DIDSSQFRLS KMADLGVATE HVLGVEVLPA SDGSVKLGLS
     WQKNIISEGF GGLILEQFDR SLTALCSSLD ADVGSLLYCH PRSDQQASSF YSVTKPVSKQ
     KCSSATFTGV ASSLNKQAIS DNSNAVEIYQ DMADSPSSRK PAATMSYPEL EQASNGVANL
     FRHLPRNSVV GVCLERGLES YIVPLAILKA GHAYLPLDAT LPLDRKKELV KDSGAALIVA
     SSKFTDFDSL TGVEMLGTDS RQFKDAVKDG KATVSVESRS DDVAFIIYTS GSTGKPKGCL
     LTQANLAAAV EGFYYNYEKE APGSFESRAR FLARSAEAFD VHLLEIFLSL RVGATIVTGP
     RALIHDDIAK TMSTLEVTHA CVVPSLFFSK GKRIEPSVVP SLRVLIIGGE ALTQDLCQIW
     GSEGSERPVV LNAYGPSEAT IGNSVARVSK KSRPSNIGAP FPGTQYLVLK DVNGQLVPTL
     RGEPGELYIG GEQVAKGYLN RPDSSSFITY QGQQIYRTGD MVRLHPSDEA EYLGRIDGSQ
     VKVRGARLEL AEVDAALSAS LNENLGTVGT AVTIHADHPK IEGAARLVSF FAQDCVRTKA
     QDSVDPGALL VQAPEAVKQS AELRRSVRAR LPQYMVPSLV LALTYLPISP LSGKADRRLL
     KELYHSIDPS KLSTLSDKNE SRQRELTDSE QTVAELVRSS VRLSSDVHLM HDLDLIMAGL
     DSLTVVTLAN KLRKHGYDAT VSSIMNEPTI EAIAGRRIDK LSSNETSDVE WKQTVSQLTD
     KVRSLPQYRG TQIETALPCV PIQVALVSQA VSDDRSTPRY ITTISIDLSS NEFSADRIRN
     AWMTALSRHE IYRTVFAEVD RTLVQVVLSA ESLTSNWSAT SEPIPSPDSL ADYHASTAKD
     IVANISSVPA LRLKLWQGEN GAPTLTLTCS HAIYDGDSIR MLLKEASDCL VTKSKVVPAL
     PFQEAARCIV GDAEDEEAKQ FWTTTLADFL PTTVPNLTGV RPEHNVSRGE ELTIASHLSF
     TQLEKAARAA KVTIQSILVA AFAHLLGLYA GESDVTLGLV LSGRSIPVDG VESIHGPCVT
     TVPLRLTDAR SNASSDLCKR AHQAVNAILP HQHVSLPQLM RWLDLSKAPF EALFSYLGQS
     ERSSEKPYFS ERASQMERDY SLALEVSAVG DAVNLHLAFD TRSMPAEQAK RMLCQYDGFL
     TVFTGTKRVD DDGKHLSILN KSCYVPTSAN ETIVARFTEH VKANPDAPAI VFASSMQEPP
     KVTSYAELDS LSTKIAFHLV HAAGPFVGVH LNKEGPELYA TILAIWKAGK AYLPLDPSLP
     VERLSYMIES VGDCPVVASH STKENLASFR CKVLDLKELV KPRSGAHELP SQNLDALCYL
     LFTSGSTGKP KAVQINQRAL AGALYSWERI LPFTRTSRFL QLASIGFDVC LIEMCMPLSL
     GFSIGTAPKQ ELLEDLTHSI KHLGITIADL PAALAGAVHP EDVRLEWLMS GGDVIDSRVV
     DEWNHAKRLL INAWGPTEAT IGNTLGQVKR GATRNLIGGV YPSSSMFVLD ENSTRILPSG
     AIGELAVGGP QLADCYYGRE ELTAEKFILL EDGTRVYRTG DLGRFLVDDT VECLGRIGSD
     RQVKVNGQRM ELDEVCSVIS AQAGVYDADV QYLKHPSMGS KQLVAFVAAA ETQAKQGDMD
     VRDDDKAIDL CIRLEQEAAK RLATYMVPTH WIVMKHGLPL THNNKTDHKA LAAFYGRMDA
     TLLRSLGAKR EGAISSHAWT QSELKLRALV SDFCNVPQDQ LARNTSFHRL GIDSISAIRL
     VKQLRTSGFT FSVADVLSTP NIAALADKQM QSSACSSDHA QPNEGLNEWI GQISSVAENE
     AWKWSSKDSL VSVLPCTPLQ SGMIAQSLAS AGGLYFHHHA FELQSTEKQH VVAAWRKLVE
     RLDILRTTFH PVDGLHPWTQ AVHSEVQPRI VQHSGSFQSC GLDAIDGQPS FQDEQAFRTP
     PFALHLWSQE GKLVVLISIH HALYDGSSLP QLLEDFEALI TGNQAKLTSR LPFYKLVPSL
     LSQDEDVQHW VNALHAFQPT LLCKRSNKPS GAAVLLEKRL ALTSQELESR CRAIGVSPQV
     LCNLTFGKLL AIESQTRDVC FGQLFGLLDL MPEADTCVGP AFNTTATRIR FQELDAPVSK
     LATTLQQAND AGRPHRRAAL RDVQAKLGRG QLFDALFDYQ RSYDQEDSKL RQIELQSDGT
     ERAQYTLNVA FVQGPSQMSI VAKADGNRYD QKALEGVVYR LEHLLEHLSI RVEEPISVLP
     DVFGETAFPL HLAQVSVANG TSTSKASAQN SANQALSQDG SKLASIISQI AGIDEMELHG
     ETRLSQLGLD SISAIRIASQ ARKAGLNLRM GEIVAGETIN AILSARSQTN ATKSSDHVNR
     NGRGNGHARV SLETAKRVAA RLAIDFEQVE RVLPVLPGQK LWLATWAQSQ GGGGFSFAYR
     LAGAEADKVK ETWQKLRQLQ PILRTAFLVH HDGGASQVVL KADSVSAGSG FAEVQVERDA
     ELTAKDVVGR RAAQGWPDLT SPPVELTLVG EIVVFSLHHV LYDAFSIEFL ARDFGSLYNA
     GELVSSNQWP EVVEHIVEEQ QRTRGDAQEY WCRALAPGSS GLLADRPGST GEAWHVQHNA
     ISLSSAVDVR IRKAGLTLAG VLLAAWSTLL SERMHDASPV FGLYQLGRSS SFESIDKVHG
     PLLNCLPIQL RGGSLLDKAR AAVSELRLRA KFEQTDLQDA HRWAGLSQHQ ACYNTFVNIL
     FGDQLDQHLE MHQLDLGHPL DYSHHSQHST HDRTPPSTPH VALPWQPDVN LDVVLKNHAV
     DIAIKANTSV VAQADLHTLV NRLVQLVHAT LELL